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- W2898096665 abstract "Abstract GABAergic interneurons are chiefly responsible for controlling the activity of local circuits in the cortex 1,2 . However, the rules that govern the wiring of interneurons are not well understood 3 . Chandelier cells (ChCs) are a type of GABAergic interneuron that control the output of hundreds of neighbouring pyramidal cells through axo-axonic synapses which target the axon initial segment (AIS) 4 . Despite their importance in modulating circuit activity, our knowledge of the development and function of axo-axonic synapses remains elusive. In this study, we investigated the role of activity in the formation and plasticity of ChC synapses. In vivo imaging of ChCs during development uncovered a narrow window (P12-P18) over which axons arborized and formed connections. We found that increases in the activity of either pyramidal cells or individual ChCs during this temporal window resulted in a reversible decrease in axo-axonic connections. Voltage imaging of GABAergic transmission at the AIS showed that axo-axonic synapses were depolarising during this period. Identical manipulations of network activity in older mice (P40-P46), when ChC synapses are inhibitory, resulted in an increase in axo-axonic synapses. We propose that the direction of ChC plasticity follows homeostatic rules that depend on the polarity of axo-axonic synapses." @default.
- W2898096665 created "2018-11-02" @default.
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- W2898096665 date "2018-10-25" @default.
- W2898096665 modified "2023-09-23" @default.
- W2898096665 title "Homeostatic plasticity rules control the wiring of axo-axonic synapses at the axon initial segment" @default.
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- W2898096665 doi "https://doi.org/10.1101/453753" @default.
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