FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898096959> ?p ?o ?g. }

• W2898096959 endingPage "1244" @default.
• W2898096959 startingPage "1230" @default.
• W2898096959 abstract "Background/Aims: Diabetic cardiomyopathy (DCM) is a common complication of diabetes and can cause heart failure, arrhythmia and sudden death. The pathogenesis of DCM includes altered metabolism, mitochondrial dysfunction, oxidative stress, inflammation, cell death and extracellular matrix remodeling. Recently, pyroptosis, a type of programmed cell death related to inflammation, was proven to be activated in DCM. However, the molecular mechanisms underlying pyroptosis in DCM remain elusive. The long non-coding RNA (lncRNA) Kcnq1ot1 participates in many cardiovascular diseases. This study aims to clarify whether Kcnq1ot1 affects cardiac pyroptosis in DCM. Methods: AC16 cells and primary cardiomyocytes were incubated with 5.5 and 50 mmol/L glucose. Diabetic mice were induced with streptozotocin (STZ). Kcnq1ot1 was silenced both in vitro and in vivo. qRT-PCR was used to detect the expression level of Kcnq1ot1. Immunofluorescence, qRT-PCR and western blot analyses were used to detect the degree of pyroptosis. Echocardiography, hematoxylin and eosin staining, and Masson’s trichrome staining were used to detect the cardiac function and morphology in mice. Cell death and function were detected using TUNEL staining, immunofluorescence staining and Ca2+ measurements. Results: The expression of Kcnq1ot1 was increased in patients with diabetes, high glucose-induced cardiomyocytes and diabetic mouse cardiac tissue. Silencing Kcnq1ot1 alleviated pyroptosis by targeting miR-214-3p and caspase-1. Furthermore, silencing Kcnq1ot1 reduced cell death, cytoskeletal structure abnormalities and calcium overload in vitro and improved cardiac function and morphology in vivo. Conclusion: Kcnq1ot1 is overexpressed in DCM, and silencing Kcnq1ot1 inhibits pyroptosis by influencing miR-214-3p and caspase-1 expression. We clarified for the first time that Kcnq1ot1 could be a new therapeutic target for DCM." @default.
• W2898096959 created "2018-11-02" @default.
• W2898096959 creator A5005410786 @default.
• W2898096959 creator A5011418238 @default.
• W2898096959 creator A5012433061 @default.
• W2898096959 creator A5032320188 @default.
• W2898096959 creator A5046856228 @default.
• W2898096959 creator A5047558450 @default.
• W2898096959 creator A5053010839 @default.
• W2898096959 creator A5059044271 @default.
• W2898096959 creator A5065749705 @default.
• W2898096959 creator A5078061801 @default.
• W2898096959 creator A5085688636 @default.
• W2898096959 date "2018-01-01" @default.
• W2898096959 modified "2023-10-18" @default.
• W2898096959 title "LncRNA KCNQ1OT1 Mediates Pyroptosis in Diabetic Cardiomyopathy" @default.
• W2898096959 cites W1978464513 @default.
• W2898096959 cites W1991430539 @default.
• W2898096959 cites W1999330035 @default.
• W2898096959 cites W2014030899 @default.
• W2898096959 cites W2020512380 @default.
• W2898096959 cites W2028600070 @default.
• W2898096959 cites W2050274889 @default.
• W2898096959 cites W2060463218 @default.
• W2898096959 cites W2073526402 @default.
• W2898096959 cites W2088999133 @default.
• W2898096959 cites W2091161969 @default.
• W2898096959 cites W2104379002 @default.
• W2898096959 cites W2117230524 @default.
• W2898096959 cites W2122297353 @default.
• W2898096959 cites W2130687298 @default.
• W2898096959 cites W2133065290 @default.
• W2898096959 cites W2144467901 @default.
• W2898096959 cites W2144518539 @default.
• W2898096959 cites W2176362990 @default.
• W2898096959 cites W2525429999 @default.
• W2898096959 cites W2540903348 @default.
• W2898096959 cites W2596178227 @default.
• W2898096959 cites W2602185627 @default.
• W2898096959 cites W2617909456 @default.
• W2898096959 cites W2618033283 @default.
• W2898096959 cites W2623461557 @default.
• W2898096959 cites W2735264179 @default.
• W2898096959 cites W2737230230 @default.
• W2898096959 cites W2740506376 @default.
• W2898096959 cites W2741632096 @default.
• W2898096959 cites W2761943380 @default.
• W2898096959 cites W2779161334 @default.
• W2898096959 cites W2783979689 @default.
• W2898096959 cites W2800512087 @default.
• W2898096959 cites W2207318881 @default.
• W2898096959 doi "https://doi.org/10.1159/000494576" @default.
• W2898096959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30355944" @default.
• W2898096959 hasPublicationYear "2018" @default.
• W2898096959 type Work @default.
• W2898096959 sameAs 2898096959 @default.
• W2898096959 citedByCount "117" @default.
• W2898096959 countsByYear W28980969592018 @default.
• W2898096959 countsByYear W28980969592019 @default.
• W2898096959 countsByYear W28980969592020 @default.
• W2898096959 countsByYear W28980969592021 @default.
• W2898096959 countsByYear W28980969592022 @default.
• W2898096959 countsByYear W28980969592023 @default.
• W2898096959 crossrefType "journal-article" @default.
• W2898096959 hasAuthorship W2898096959A5005410786 @default.
• W2898096959 hasAuthorship W2898096959A5011418238 @default.
• W2898096959 hasAuthorship W2898096959A5012433061 @default.
• W2898096959 hasAuthorship W2898096959A5032320188 @default.
• W2898096959 hasAuthorship W2898096959A5046856228 @default.
• W2898096959 hasAuthorship W2898096959A5047558450 @default.
• W2898096959 hasAuthorship W2898096959A5053010839 @default.
• W2898096959 hasAuthorship W2898096959A5059044271 @default.
• W2898096959 hasAuthorship W2898096959A5065749705 @default.
• W2898096959 hasAuthorship W2898096959A5078061801 @default.
• W2898096959 hasAuthorship W2898096959A5085688636 @default.
• W2898096959 hasBestOaLocation W28980969591 @default.
• W2898096959 hasConcept C104317684 @default.
• W2898096959 hasConcept C119056186 @default.
• W2898096959 hasConcept C126322002 @default.
• W2898096959 hasConcept C142724271 @default.
• W2898096959 hasConcept C17172800 @default.
• W2898096959 hasConcept C173396325 @default.
• W2898096959 hasConcept C190283241 @default.
• W2898096959 hasConcept C2776553924 @default.
• W2898096959 hasConcept C2776914184 @default.
• W2898096959 hasConcept C2777209026 @default.
• W2898096959 hasConcept C2778198053 @default.
• W2898096959 hasConcept C2778797674 @default.
• W2898096959 hasConcept C31573885 @default.
• W2898096959 hasConcept C55493867 @default.
• W2898096959 hasConcept C71924100 @default.
• W2898096959 hasConcept C86803240 @default.
• W2898096959 hasConcept C95444343 @default.
• W2898096959 hasConceptScore W2898096959C104317684 @default.
• W2898096959 hasConceptScore W2898096959C119056186 @default.
• W2898096959 hasConceptScore W2898096959C126322002 @default.
• W2898096959 hasConceptScore W2898096959C142724271 @default.
• W2898096959 hasConceptScore W2898096959C17172800 @default.

• next