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- W2898098339 abstract "Chronic kidney disease, the gradual loss of renal function, is an increasingly recognized burden for patients and health care systems; globally, it has a high and rapidly growing prevalence, a significant mortality, and causes disproportionately high costs, particularly for hemodialysis and kidney transplantations. Yet, the available diagnostic tools are either impractical in clinical routine or have serious shortcomings preventing a well-informed disease management, although optimized treatment strategies with impressive benefits for patients have been established. Advances in bioanalytics have facilitated the identification of many genomic, proteomic, and metabolic biomarker candidates, some of which have been validated in independent cohorts. Summarizing the markers discovered so far, this chapter focuses on compounds or pathways, for which quantitative data, substantiating evidence from translational research, and a mechanistic understanding is available. Also, multiparametric marker panels have been suggested with promising diagnostic and prognostic performance in initial analyses, although the data basis from prospective trials is very limited. Large-scale studies, however, are underway and will validate certain sets of parameters and discard others. Finally, the path from clinical research to routine application is discussed, focusing on potential obstacles such as the use of mass spectrometry, and the feasibility of obtaining regulatory approval for metabolomics assays." @default.
- W2898098339 created "2018-11-02" @default.
- W2898098339 creator A5065664298 @default.
- W2898098339 creator A5078595079 @default.
- W2898098339 date "2018-10-24" @default.
- W2898098339 modified "2023-09-26" @default.
- W2898098339 title "Towards Metabolic Biomarkers for the Diagnosis and Prognosis of CKD" @default.
- W2898098339 cites W1046164915 @default.
- W2898098339 cites W107379563 @default.
- W2898098339 cites W138419469 @default.
- W2898098339 cites W146927540 @default.
- W2898098339 cites W1516189339 @default.
- W2898098339 cites W1550111394 @default.
- W2898098339 cites W1559508931 @default.
- W2898098339 cites W1608848398 @default.
- W2898098339 cites W1680640252 @default.
- W2898098339 cites W1867398097 @default.
- W2898098339 cites W1893556128 @default.
- W2898098339 cites W193268008 @default.
- W2898098339 cites W1965675690 @default.
- W2898098339 cites W1968430889 @default.
- W2898098339 cites W1968460061 @default.
- W2898098339 cites W1969756705 @default.
- W2898098339 cites W1969887535 @default.
- W2898098339 cites W1970253141 @default.
- W2898098339 cites W1971262306 @default.
- W2898098339 cites W1973002697 @default.
- W2898098339 cites W1973529232 @default.
- W2898098339 cites W1977176813 @default.
- W2898098339 cites W1977576899 @default.
- W2898098339 cites W1979404842 @default.
- W2898098339 cites W1980046832 @default.
- W2898098339 cites W1980218015 @default.
- W2898098339 cites W1980448293 @default.
- W2898098339 cites W1980481877 @default.
- W2898098339 cites W1983480089 @default.
- W2898098339 cites W1987216226 @default.
- W2898098339 cites W1987524865 @default.
- W2898098339 cites W1988578594 @default.
- W2898098339 cites W1988892943 @default.
- W2898098339 cites W1989022203 @default.
- W2898098339 cites W1990038658 @default.
- W2898098339 cites W1992614209 @default.
- W2898098339 cites W1994501150 @default.
- W2898098339 cites W1996387976 @default.
- W2898098339 cites W1999029838 @default.
- W2898098339 cites W1999505725 @default.
- W2898098339 cites W2000323959 @default.
- W2898098339 cites W2001260124 @default.
- W2898098339 cites W2001771035 @default.
- W2898098339 cites W2002401584 @default.
- W2898098339 cites W2002599787 @default.
- W2898098339 cites W2002689588 @default.
- W2898098339 cites W2003568146 @default.
- W2898098339 cites W2004122933 @default.
- W2898098339 cites W2006141598 @default.
- W2898098339 cites W2010711991 @default.
- W2898098339 cites W2012836981 @default.
- W2898098339 cites W2017015351 @default.
- W2898098339 cites W2017771330 @default.
- W2898098339 cites W2018680608 @default.
- W2898098339 cites W2019015726 @default.
- W2898098339 cites W2021426287 @default.
- W2898098339 cites W2023091041 @default.
- W2898098339 cites W2024147658 @default.
- W2898098339 cites W2025589168 @default.
- W2898098339 cites W2025930235 @default.
- W2898098339 cites W2026582325 @default.
- W2898098339 cites W2026633060 @default.
- W2898098339 cites W2027358831 @default.
- W2898098339 cites W2027387500 @default.
- W2898098339 cites W2028292525 @default.
- W2898098339 cites W2028735580 @default.
- W2898098339 cites W2029742084 @default.
- W2898098339 cites W2030522563 @default.
- W2898098339 cites W2030667838 @default.
- W2898098339 cites W2031017520 @default.
- W2898098339 cites W2036200256 @default.
- W2898098339 cites W2036613336 @default.
- W2898098339 cites W2036709961 @default.
- W2898098339 cites W2037116841 @default.
- W2898098339 cites W2044999311 @default.
- W2898098339 cites W2045516356 @default.
- W2898098339 cites W2049131515 @default.
- W2898098339 cites W2049654331 @default.
- W2898098339 cites W2050071967 @default.
- W2898098339 cites W2050515508 @default.
- W2898098339 cites W2050703495 @default.
- W2898098339 cites W2052425001 @default.
- W2898098339 cites W2055094918 @default.
- W2898098339 cites W2055864845 @default.
- W2898098339 cites W2055953242 @default.
- W2898098339 cites W2055965302 @default.
- W2898098339 cites W2056822978 @default.
- W2898098339 cites W2056903366 @default.
- W2898098339 cites W2057129789 @default.
- W2898098339 cites W2057131826 @default.
- W2898098339 cites W2057824539 @default.
- W2898098339 cites W2058385357 @default.
- W2898098339 cites W2059184579 @default.