FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898100314> ?p ?o ?g. }

• W2898100314 endingPage "407" @default.
• W2898100314 startingPage "401" @default.
• W2898100314 abstract "Primary central nervous system lymphoma ( PCNSL ) is a rare subtype of lymphoma that arises within the brain or the eyes. PCNSL recurs within the central nervous system ( CNS ) in most relapsed cases, whereas extra‐ CNS relapse is experienced in rare cases. The present study aimed at identifying the presence of common precursor cells ( CPC ) for primary intra‐ and relapsed extra‐ CNS tumors, and further assessing the initiating events in bone marrow ( BM ). Targeted deep sequencing was carried out for five paired primary intra‐ and relapsed extra‐ CNS tumors of PCNSL . Two to five mutations were shared by each pair of intra‐ and extra‐ CNS tumors. In particular, MYD 88 mutations, L265P in three and P258L in one, were shared by four pairs. Unique somatic mutations were observed in all five intra‐ CNS tumors and in four out of five extra‐ CNS tumors. Remarkably, IgH clones in the intra‐ and the extra‐ CNS tumors in two pairs were distinct from each other, whereas one pair of tumors shared identical monoclonal IgH rearrangement. In a cohort of 23 PCNSL patients, L265P MYD 88 mutations were examined in tumor‐free BM mononuclear cells ( MNC ) in which the PCNSL tumors had L265P MYD 88 mutations. L265P MYD 88 mutations were detected by a droplet digital PCR method in nine out of 23 bone marrow mononuclear cells. These results suggest that intra‐ and extra‐tumors are derived from CPC with MYD 88 mutations in most PCNSL , arising either before or after IgH rearrangement. The initiating MYD 88 mutations may occur during B‐cell differentiation in BM ." @default.
• W2898100314 created "2018-11-02" @default.
• W2898100314 creator A5005251373 @default.
• W2898100314 creator A5010836878 @default.
• W2898100314 creator A5012609268 @default.
• W2898100314 creator A5014405945 @default.
• W2898100314 creator A5038239367 @default.
• W2898100314 creator A5038270737 @default.
• W2898100314 creator A5046158070 @default.
• W2898100314 creator A5047339117 @default.
• W2898100314 creator A5051611223 @default.
• W2898100314 creator A5054408940 @default.
• W2898100314 creator A5061599783 @default.
• W2898100314 creator A5064026305 @default.
• W2898100314 creator A5067804516 @default.
• W2898100314 creator A5068565363 @default.
• W2898100314 creator A5078524474 @default.
• W2898100314 creator A5082957036 @default.
• W2898100314 creator A5084193213 @default.
• W2898100314 creator A5085355727 @default.
• W2898100314 date "2018-11-18" @default.
• W2898100314 modified "2023-10-14" @default.
• W2898100314 title "Genetic evidence implies that primary and relapsed tumors arise from common precursor cells in primary central nervous system lymphoma" @default.
• W2898100314 cites W1511785830 @default.
• W2898100314 cites W1980485397 @default.
• W2898100314 cites W1987821195 @default.
• W2898100314 cites W1990561497 @default.
• W2898100314 cites W2010052778 @default.
• W2898100314 cites W2029253774 @default.
• W2898100314 cites W2036832665 @default.
• W2898100314 cites W2056162873 @default.
• W2898100314 cites W2058119596 @default.
• W2898100314 cites W2116957041 @default.
• W2898100314 cites W2126816979 @default.
• W2898100314 cites W2132135544 @default.
• W2898100314 cites W2133545780 @default.
• W2898100314 cites W2136272158 @default.
• W2898100314 cites W2146146853 @default.
• W2898100314 cites W2148495628 @default.
• W2898100314 cites W2148800442 @default.
• W2898100314 cites W2149858388 @default.
• W2898100314 cites W2153202563 @default.
• W2898100314 cites W2237189228 @default.
• W2898100314 cites W2282026400 @default.
• W2898100314 cites W2331896021 @default.
• W2898100314 cites W2355652889 @default.
• W2898100314 cites W2407062960 @default.
• W2898100314 cites W2610523006 @default.
• W2898100314 cites W2620922003 @default.
• W2898100314 cites W4239999715 @default.
• W2898100314 cites W4249917002 @default.
• W2898100314 doi "https://doi.org/10.1111/cas.13848" @default.
• W2898100314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6317941" @default.
• W2898100314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30353605" @default.
• W2898100314 hasPublicationYear "2018" @default.
• W2898100314 type Work @default.
• W2898100314 sameAs 2898100314 @default.
• W2898100314 citedByCount "17" @default.
• W2898100314 countsByYear W28981003142019 @default.
• W2898100314 countsByYear W28981003142020 @default.
• W2898100314 countsByYear W28981003142021 @default.
• W2898100314 countsByYear W28981003142023 @default.
• W2898100314 crossrefType "journal-article" @default.
• W2898100314 hasAuthorship W2898100314A5005251373 @default.
• W2898100314 hasAuthorship W2898100314A5010836878 @default.
• W2898100314 hasAuthorship W2898100314A5012609268 @default.
• W2898100314 hasAuthorship W2898100314A5014405945 @default.
• W2898100314 hasAuthorship W2898100314A5038239367 @default.
• W2898100314 hasAuthorship W2898100314A5038270737 @default.
• W2898100314 hasAuthorship W2898100314A5046158070 @default.
• W2898100314 hasAuthorship W2898100314A5047339117 @default.
• W2898100314 hasAuthorship W2898100314A5051611223 @default.
• W2898100314 hasAuthorship W2898100314A5054408940 @default.
• W2898100314 hasAuthorship W2898100314A5061599783 @default.
• W2898100314 hasAuthorship W2898100314A5064026305 @default.
• W2898100314 hasAuthorship W2898100314A5067804516 @default.
• W2898100314 hasAuthorship W2898100314A5068565363 @default.
• W2898100314 hasAuthorship W2898100314A5078524474 @default.
• W2898100314 hasAuthorship W2898100314A5082957036 @default.
• W2898100314 hasAuthorship W2898100314A5084193213 @default.
• W2898100314 hasAuthorship W2898100314A5085355727 @default.
• W2898100314 hasBestOaLocation W28981003141 @default.
• W2898100314 hasConcept C104317684 @default.
• W2898100314 hasConcept C142724271 @default.
• W2898100314 hasConcept C169760540 @default.
• W2898100314 hasConcept C203014093 @default.
• W2898100314 hasConcept C2779338263 @default.
• W2898100314 hasConcept C2780007613 @default.
• W2898100314 hasConcept C2781173314 @default.
• W2898100314 hasConcept C501734568 @default.
• W2898100314 hasConcept C502942594 @default.
• W2898100314 hasConcept C529278444 @default.
• W2898100314 hasConcept C54355233 @default.
• W2898100314 hasConcept C71924100 @default.
• W2898100314 hasConcept C86803240 @default.
• W2898100314 hasConceptScore W2898100314C104317684 @default.
• W2898100314 hasConceptScore W2898100314C142724271 @default.
• W2898100314 hasConceptScore W2898100314C169760540 @default.

• next