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- W2898103650 abstract "Trade-offs between protein stability and activity can restrict access to evolutionary trajectories, but widespread epistasis may facilitate indirect routes to adaptation. This may be enhanced by natural environmental variation, but in multicellular organisms this process is poorly understood. We investigated a paradoxical trajectory taken during the evolution of tetrapod dim-light vision, where in the rod visual pigment rhodopsin, E122 was fixed 350 million years ago, a residue associated with increased active-state (MII) stability but greatly diminished rod photosensitivity. Here, we demonstrate that high MII stability could have likely evolved without E122, but instead, selection appears to have entrenched E122 in tetrapods via epistatic interactions with nearby coevolving sites. In fishes by contrast, selection may have exploited these epistatic effects to explore alternative trajectories, but via indirect routes with low MII stability. Our results suggest that within tetrapods, E122 and high MII stability cannot be sacrificed—not even for improvements to rod photosensitivity." @default.
- W2898103650 created "2018-11-02" @default.
- W2898103650 creator A5002949528 @default.
- W2898103650 creator A5044672136 @default.
- W2898103650 date "2018-10-26" @default.
- W2898103650 modified "2023-10-11" @default.
- W2898103650 title "Functional trade-offs and environmental variation shaped ancient trajectories in the evolution of dim-light vision" @default.
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