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- W2898110940 abstract "Carcinoma lung carries poor prognosis and is the leading cause of death among all malignancies. In developing countries like India, two-third of patients present with advanced stage of disease, where survival is dismal. Hence a retrospective study was planned to be conducted to observe the clinicopathological profile of patients presenting with metastatic lung carcinoma and to analyse the treatment response and survival in these cases. A retrospective analysis was done from hospital files of patients with metastatic carcinoma lung presenting to our hospital from January 2015 to April 2018. Out of 55 patients of metastatic lung carcinoma ,36(65%) were male and 19(35%) were female. Majority of the patients were of elderly age group >60yrs i.e. 47%(36patients),followed by 40-60yrs age group i.e. 31%(17 patients).Considering laterality of primary malignancy, right lung was more commonly affected than left lung(60% vs 40%).Histopathologically adenocarcinoma was the most common variety encountered(85.45%,47 patients) followed by squamous cell variety(0.9%,5 patients).Among 47 patients of adenocarcinoma variety,20 patients(42.5%)have EGFR mutations, whereas 27 patients(57.5%) were EGFR nonmutated. The pattern of metastases shows single organ metastasis in 19 patients (34.5%) and multiple organ metastases in 36 patients(65.5%). Overall bone was the most common site (25 patients) of metastases whereas brain was the most common single organ metastasis site. The follow-up period ranged from 2months to 40 months(median follow-up period-7mnths).One year and two year overall survival was 30% and 10.9% respectively. Subgroup analysis between patients who have received Tyrosine Kinase Inhibitors(TKI)±chemotherapy group and those who have received chemotherapy only group showed median overall survival of 19 months vs 6mnths respectively. In spite of increased awareness, incidence of metastatic lung carcinoma is still high. Adenocarcinoma is the most common histopathological variety. Bone contralateral lung and brain were the common organs involved by metastases. EGFR mutation status should be assessed in all cases of adenocarcinoma lung. Adding TKI in EGFR mutated cases has shown increased survival in our study. Larger sample size and longer follow-up period can further validify the results." @default.
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- W2898110940 date "2018-10-01" @default.
- W2898110940 modified "2023-10-14" @default.
- W2898110940 title "P3.01-21 Metastatic Lung Carcinoma —An Institutional Experience from Eastern India" @default.
- W2898110940 doi "https://doi.org/10.1016/j.jtho.2018.08.1581" @default.
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