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• W2898138790 abstract "Tumor grade is an important factor of cancer outcome. Systematic inflammation has been associated with tumorigenesis and tumor aggressiveness and prognosis in several human malignancies. Cancer cells create an inflammatory peritumoral microenviroment by releasing a number of cytokines. In total, 100 patients (88 males) with histologically proven NSCLC and no signs of active infection were evaluated. Tumor grade was examined and systematic inflammatory response was assessed by circulating levels of C-reactive protein (CRP), albumin, ferritin, transferring and the modified Glasgow Prognostic Score (mGPS). Patients were followed up and survival data were subsequently collected. Associations with clinicopathological, histological parameters and patients’ survival were studied. Histological grade was associated with tumor size, the presence of pathological lymph nodes, organ metastases and advanced disease stage (p=0.010, p<0.001, p<0.001 and p<0.001, respectively). There was a trend of higher histological grade in adenocarcinomas compared to squamous carcinomas (p=0.263). High tumor histological grade was also significantly associated with elevated serum CRP levels (p<0.001), hypoalbuminemia (p=0.009), elevated ferritin levels (p=0.049), abnormal mGPS (p=0.006) and a trend for reduced transferrin levels (p=0.101). In multivariate analysis, histological grade, stage, ECOG performance status and mGPS were identified as independent prognostic factors for overall survival (Cox regression analysis, p=0.002, p=0.001, p=0.010 and p=0.019, respectively). Our data support the association of tumour grade with the presence of systemic inflammation; two well described negative prognostic factors for NSCLC. To our knowledge this is the first time that these factors are associated with each other giving more information about the prognosis in patients with NSCLC." @default.
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• W2898138790 date "2018-10-01" @default.
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• W2898138790 title "P1.09-35 Clinical Impact of Systematic Inflammation and Histologic Grade in Non Small Cell Lung Carcinoma (NSCLC)" @default.
• W2898138790 doi "https://doi.org/10.1016/j.jtho.2018.08.811" @default.
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