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• W2898156723 abstract "Purpose: Epidemiological evidence regarding the radiosensitivity of the lens of the eye and radiation cataract development has led to changes in the EU Basic Safety Standards for protection of the lens against ionizing radiation. However, mechanistic details of lens radiation response pathways and their significance for cataractogenesis remain unclear. Radiation-induced DNA damage and the potential impairment of repair pathways within the lens epithelium, a cell monolayer that covers the anterior hemisphere of the lens, are likely to be involved.Materials and Methods: In this work, the lens epithelium has been analyzed for its DNA double-strand break (DSB) repair response to ionizing radiation. The responses of epithelial cells located at the anterior pole (central region) have been compared to at the very periphery of the monolayer (germinative and transitional zones). Described here are the different responses in the two regions and across four strains (C57BL/6, 129S2, BALB/c and CBA/Ca) over a low dose (0–25 mGy) in-vivo whole body X-irradiation range up to 24 hours post exposure.Results: DNA damage and repair as visualized through 53BP1 staining was present across the lens epithelium, although repair kinetics appeared non-uniform. Epithelial cells in the central region have significantly more 53BP1 foci. The sensitivities of different mouse strains have also been compared.Conclusions: 129S2 and BALB/c showed higher levels of DNA damage, with BALB/c showing significantly less inter-individual variability and appearing to be a more robust model for future DNA damage and repair studies. As a result of this study, BALB/c was identified as a suitable radiosensitive lens strain to detect and quantify early low dose ionizing radiation DNA damage effects in the mouse eye lens specifically, as an indicator of cataract formation." @default.
• W2898156723 created "2018-11-02" @default.
• W2898156723 creator A5001325663 @default.
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• W2898156723 date "2018-10-25" @default.
• W2898156723 modified "2023-10-18" @default.
• W2898156723 title "Dotting the eyes: mouse strain dependency of the lens epithelium to low dose radiation-induced DNA damage" @default.
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• W2898156723 cites W1937256520 @default.
• W2898156723 cites W1970018332 @default.
• W2898156723 cites W1977805682 @default.
• W2898156723 cites W1982227917 @default.
• W2898156723 cites W1984266465 @default.
• W2898156723 cites W1985549353 @default.
• W2898156723 cites W1986805842 @default.
• W2898156723 cites W1989052059 @default.
• W2898156723 cites W1992060814 @default.
• W2898156723 cites W2005116685 @default.
• W2898156723 cites W2008536823 @default.
• W2898156723 cites W2009947212 @default.
• W2898156723 cites W2011544722 @default.
• W2898156723 cites W2019219567 @default.
• W2898156723 cites W2026297273 @default.
• W2898156723 cites W2035457879 @default.
• W2898156723 cites W2035666100 @default.
• W2898156723 cites W2042218859 @default.
• W2898156723 cites W2052660678 @default.
• W2898156723 cites W2055997710 @default.
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• W2898156723 cites W2080313089 @default.
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• W2898156723 cites W2119675439 @default.
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• W2898156723 cites W2121695005 @default.
• W2898156723 cites W2125297918 @default.
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• W2898156723 doi "https://doi.org/10.1080/09553002.2018.1532609" @default.
• W2898156723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30359158" @default.
• W2898156723 hasPublicationYear "2018" @default.
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