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• W2898185993 abstract "Objectives To measure the association between statin exposure and mortality in lung cancer patients belonging to different categories of histological subtype. Materials and methods A cohort of 19,974 individuals with incident lung cancer between 2007 and 2011 was identified using the SEER-Medicare linked database. Statin exposure both pre- and post-diagnosis was analyzed to identify a possible association with cancer-specific mortality in patients stratified by histological subtype. Intention-to-treat analyses and time-dependent Cox regression models were used to calculate hazard ratios and 95% confidence intervals (95% CIs) corresponding to statin exposure both pre- and post-diagnosis, respectively. Results Overall baseline statin exposure was associated with a decrease in mortality risk for squamous-cell carcinoma patients (HR = 0.89, 95% CI = 0.82–0.96) and adenocarcinoma patients (HR = 0.87, 95% CI = 0.82–0.94), but not among those with small-cell lung cancer. Post-diagnostic statin exposure was associated with prolonged survival in squamous-cell carcinoma patients (HR = 0.68, 95% CI = 0.59–0.79) and adenocarcinoma patients (HR = 0.78, 95% CI = 0.68–0.89) in a dose-dependent manner. Conclusion There is consistent evidence indicating that baseline or post-diagnostic exposure to simvastatin and atorvastatin is associated with extended survival in non-small-cell lung cancer subtypes. These results warrant further randomized clinical trials to evaluate subtype-specific effects of certain statins in patient cohorts with characteristics similar to those examined in this study." @default.
• W2898185993 created "2018-11-02" @default.
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• W2898185993 date "2018-12-01" @default.
• W2898185993 modified "2023-10-13" @default.
• W2898185993 title "Statins associate with improved mortality among patients with certain histological subtypes of lung cancer" @default.
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• W2898185993 doi "https://doi.org/10.1016/j.lungcan.2018.10.022" @default.
• W2898185993 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6296763" @default.
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