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- W2898188130 abstract "Non-Alcoholic Fatty Liver Disease (NAFLD) has been recognized as the most common liver disorder in developed countries. NAFLD progresses from fat accumulation in hepatocytes to steatohepatitis to further stages of fibrosis and cirrhosis. Simple steatosis, i.e. fat deposition in the liver, is considered benign and gives way to non-alcoholic steatohepatitis (NASH) with a higher probability of progressing to cirrhosis, and liver-related mortality. Evidence has been found that this progression has been associated with marked alterations in hepatocyte histology and a shift in marker expression of healthy hepatocytes including increased expression of peroxisome proliferator-activated receptor gamma (PPARγ), adipocyte protein (aP2), CD36, interleukin-6 (IL-6), interleukin-18 (IL-18) and adiponectin. This progression shares much in common with the obesity phenotype, which involves a transformation of adipocytes from small, healthy cells to large, dysfunctional ones that contribute to redox imbalance and the progression of metabolic syndrome. Further, activation of Src/ERK signaling via the sodium potassium adenosine triphosphatase (Na/K-ATPase) α-1 subunit in impaired hepatocytes may contribute to redox imbalance, exacerbating the progression of NAFLD. This review hypothesizes that an adipogenic transformation of hepatocytes propagates redox imbalance and that the processes occurring in adipogenesis become activated in fat-laden hepatocytes in liver, thereby driving progression to NAFLD. Further, this review discusses therapeutic interventions to reverse NAFLD including the thiazolidinediones (TZDs) and a variety of antioxidant species. The peptide, pNaKtide, which is an antagonist of Na/K-ATPase signaling, is also proposed as a potential pharmacologic option for reducing reactive oxygen species (ROS) and reversing NAFLD by inhibiting the Na/K-ATPase-modulated ROS amplification loop." @default.
- W2898188130 created "2018-11-02" @default.
- W2898188130 creator A5005428451 @default.
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- W2898188130 creator A5077735587 @default.
- W2898188130 creator A5078169233 @default.
- W2898188130 date "2018-01-01" @default.
- W2898188130 modified "2023-09-23" @default.
- W2898188130 title "Phenotypic Alteration of Hepatocytes in Non-Alcoholic Fatty Liver Disease" @default.
- W2898188130 cites W109033710 @default.
- W2898188130 cites W1559657606 @default.
- W2898188130 cites W1566461421 @default.
- W2898188130 cites W1856151485 @default.
- W2898188130 cites W1870581883 @default.
- W2898188130 cites W1881100739 @default.
- W2898188130 cites W1882608036 @default.
- W2898188130 cites W1922087192 @default.
- W2898188130 cites W1965114923 @default.
- W2898188130 cites W1968396962 @default.
- W2898188130 cites W1976060830 @default.
- W2898188130 cites W1976902613 @default.
- W2898188130 cites W1982998620 @default.
- W2898188130 cites W1991938154 @default.
- W2898188130 cites W2000223380 @default.
- W2898188130 cites W2003110890 @default.
- W2898188130 cites W2003403665 @default.
- W2898188130 cites W2004205302 @default.
- W2898188130 cites W2004461660 @default.
- W2898188130 cites W2009565165 @default.
- W2898188130 cites W2013429438 @default.
- W2898188130 cites W2014221097 @default.
- W2898188130 cites W2017948134 @default.
- W2898188130 cites W2019280401 @default.
- W2898188130 cites W2020960905 @default.
- W2898188130 cites W2023503151 @default.
- W2898188130 cites W2025296211 @default.
- W2898188130 cites W2029811522 @default.
- W2898188130 cites W2030628693 @default.
- W2898188130 cites W2033792510 @default.
- W2898188130 cites W2034298464 @default.
- W2898188130 cites W2035458523 @default.
- W2898188130 cites W2049384958 @default.
- W2898188130 cites W2052609811 @default.
- W2898188130 cites W2060978273 @default.
- W2898188130 cites W2062812115 @default.
- W2898188130 cites W2066805219 @default.
- W2898188130 cites W2067740038 @default.
- W2898188130 cites W2069421664 @default.
- W2898188130 cites W2070610372 @default.
- W2898188130 cites W2078176020 @default.
- W2898188130 cites W2085097924 @default.
- W2898188130 cites W2085354876 @default.
- W2898188130 cites W2095784428 @default.
- W2898188130 cites W2095977252 @default.
- W2898188130 cites W2098293941 @default.
- W2898188130 cites W2102040704 @default.
- W2898188130 cites W2102782957 @default.
- W2898188130 cites W2103809310 @default.
- W2898188130 cites W2103969932 @default.
- W2898188130 cites W2104139918 @default.
- W2898188130 cites W2108324021 @default.
- W2898188130 cites W2111045432 @default.
- W2898188130 cites W2116947619 @default.
- W2898188130 cites W2120480222 @default.
- W2898188130 cites W2122252852 @default.
- W2898188130 cites W2124038922 @default.
- W2898188130 cites W2124821727 @default.
- W2898188130 cites W2126196420 @default.
- W2898188130 cites W2127179996 @default.
- W2898188130 cites W2129737282 @default.
- W2898188130 cites W2135550833 @default.
- W2898188130 cites W2135757247 @default.
- W2898188130 cites W2137835350 @default.
- W2898188130 cites W2138226825 @default.
- W2898188130 cites W2138774651 @default.
- W2898188130 cites W2140068099 @default.
- W2898188130 cites W2145725957 @default.
- W2898188130 cites W2147554487 @default.
- W2898188130 cites W2157671355 @default.
- W2898188130 cites W2162572769 @default.
- W2898188130 cites W2166623757 @default.
- W2898188130 cites W2171480976 @default.
- W2898188130 cites W2173681478 @default.
- W2898188130 cites W2175474731 @default.
- W2898188130 cites W2179419395 @default.
- W2898188130 cites W2253667517 @default.
- W2898188130 cites W2262387844 @default.
- W2898188130 cites W2276593581 @default.
- W2898188130 cites W2329564510 @default.
- W2898188130 cites W2344868259 @default.
- W2898188130 cites W2513420589 @default.
- W2898188130 cites W2528486210 @default.
- W2898188130 cites W2592251528 @default.
- W2898188130 cites W2622908974 @default.