FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898192015> ?p ?o ?g. }

• W2898192015 endingPage "1974" @default.
• W2898192015 startingPage "1959" @default.
• W2898192015 abstract "Management of complicated skin and soft tissue infections with a special focus on the role of newer antibiotics Hoe Nam Leong,1 Asok Kurup,2 Mak Yong Tan,3 Andrea Lay Hoon Kwa,4,5 Kui Hin Liau,6 Mark H Wilcox7 1Rophi Clinic, Mount Elizabeth Novena Specialist Centre, Singapore, Singapore; 2Infectious Diseases Care Private Ltd, Mount Elizabeth Medical Centre, Singapore, Singapore; 3My Orthopaedic Clinic, Gleneagles Medical Centre, Singapore, Singapore; 4Department of Pharmacy, Singapore General Hospital, Singapore, Singapore; 5Emerging Infectious Diseases Program, Duke-National University of Singapore Medical School, Singapore, Singapore; 6LIAU KH Specialist Clinic, Mount Elizabeth Novena Specialist Centre, Singapore, Singapore; 7Department of Medical Microbiology, Leeds Teaching Hospitals and University of Leeds, Leeds, UK Abstract: Complicated skin and soft tissue infections (cSSTIs) represent the severe form of infectious disease that involves deeper soft tissues. Involvement of methicillin-resistant Staphylococcus aureus (MRSA) further complicates cSSTI with increased hospitalization, health care costs, and overall mortality. Various international guidelines provide recommendations on the management of cSSTIs, with the inclusion of newer antibiotics. This literature-based review discusses the overall management of cSSTI, including appropriate use of antibiotics in clinical practice. Successful treatment of cSSTIs starts with early and precise diagnosis, including identification of causative pathogen and its load, determination of infection severity, associated complications, and risk factors. The current standard-of-care for cSSTIs involves incision, drainage, surgical debridement, broad-spectrum antibiotic therapy, and supportive care. In recent years, the emergence of newer antibiotics (eg, ceftaroline, tigecycline, daptomycin, linezolid, etc) has provided clinicians wider options of antimicrobial therapy. Selection of antibiotics should be based on the drug characteristics, effectiveness, safety, and treatment costs, alongside other aspects such as host factors and local multidrug resistance rates. However, larger studies on newer antibiotics are warranted to refine the decision making on the appropriate antimicrobial therapy. Local Antimicrobial Stewardship Program strategies in health care settings could guide clinicians for early initiation of specific treatments to combat region-specific antimicrobial resistance, minimize adverse effects, and to improve outcomes such as reduction in Clostridium difficile infections. These strategies involving iv-to-oral switch, de-escalation to narrow-spectrum antibiotics, and dose optimization have an impact on the overall improvement of cSSTI therapy outcomes, especially in countries like Singapore that has a high disease burden. Keywords: antibiotics, complicated skin and soft tissue infections, methicillin-resistant Staphylococcus aureus, Singapore" @default.
• W2898192015 created "2018-11-02" @default.
• W2898192015 creator A5003258482 @default.
• W2898192015 creator A5019177579 @default.
• W2898192015 creator A5020108828 @default.
• W2898192015 creator A5027928189 @default.
• W2898192015 creator A5031140827 @default.
• W2898192015 creator A5052187793 @default.
• W2898192015 date "2018-10-01" @default.
• W2898192015 modified "2023-09-24" @default.
• W2898192015 title "Management of complicated skin and soft tissue infections with a special focus on the role of newer antibiotics" @default.
• W2898192015 cites W1552394333 @default.
• W2898192015 cites W1602812868 @default.
• W2898192015 cites W1748063039 @default.
• W2898192015 cites W1820911479 @default.
• W2898192015 cites W1892594438 @default.
• W2898192015 cites W1927816688 @default.
• W2898192015 cites W1931135809 @default.
• W2898192015 cites W1964024657 @default.
• W2898192015 cites W1967587362 @default.
• W2898192015 cites W1970780793 @default.
• W2898192015 cites W1976915176 @default.
• W2898192015 cites W1978676586 @default.
• W2898192015 cites W1978811229 @default.
• W2898192015 cites W1980304686 @default.
• W2898192015 cites W1984464913 @default.
• W2898192015 cites W1985261796 @default.
• W2898192015 cites W1986456514 @default.
• W2898192015 cites W1987653198 @default.
• W2898192015 cites W1990293025 @default.
• W2898192015 cites W1990740766 @default.
• W2898192015 cites W1994847675 @default.
• W2898192015 cites W1996738507 @default.
• W2898192015 cites W2000748652 @default.
• W2898192015 cites W2012207645 @default.
• W2898192015 cites W2014898485 @default.
• W2898192015 cites W2019351961 @default.
• W2898192015 cites W2020917606 @default.
• W2898192015 cites W2025782712 @default.
• W2898192015 cites W2028328891 @default.
• W2898192015 cites W2030539985 @default.
• W2898192015 cites W2031140786 @default.
• W2898192015 cites W2031446763 @default.
• W2898192015 cites W2035484777 @default.
• W2898192015 cites W2036206262 @default.
• W2898192015 cites W2036373944 @default.
• W2898192015 cites W2036430311 @default.
• W2898192015 cites W2046583637 @default.
• W2898192015 cites W2046688988 @default.
• W2898192015 cites W2048402564 @default.
• W2898192015 cites W2049063050 @default.
• W2898192015 cites W2050619118 @default.
• W2898192015 cites W2053886705 @default.
• W2898192015 cites W2056271497 @default.
• W2898192015 cites W2071078670 @default.
• W2898192015 cites W2076914309 @default.
• W2898192015 cites W2079072034 @default.
• W2898192015 cites W2079812921 @default.
• W2898192015 cites W2085409853 @default.
• W2898192015 cites W2088627734 @default.
• W2898192015 cites W2091382682 @default.
• W2898192015 cites W2092084708 @default.
• W2898192015 cites W2092973221 @default.
• W2898192015 cites W2093345619 @default.
• W2898192015 cites W2096013123 @default.
• W2898192015 cites W2099274786 @default.
• W2898192015 cites W2100386403 @default.
• W2898192015 cites W2101357306 @default.
• W2898192015 cites W2101417284 @default.
• W2898192015 cites W2101769355 @default.
• W2898192015 cites W2103444120 @default.
• W2898192015 cites W210370987 @default.
• W2898192015 cites W2106826123 @default.
• W2898192015 cites W2107594595 @default.
• W2898192015 cites W2108433768 @default.
• W2898192015 cites W2110099980 @default.
• W2898192015 cites W2110433307 @default.
• W2898192015 cites W2110682447 @default.
• W2898192015 cites W2116016317 @default.
• W2898192015 cites W2116814997 @default.
• W2898192015 cites W2117409056 @default.
• W2898192015 cites W2120632666 @default.
• W2898192015 cites W2121301182 @default.
• W2898192015 cites W2121978874 @default.
• W2898192015 cites W2122890348 @default.
• W2898192015 cites W2122909249 @default.
• W2898192015 cites W2128732736 @default.
• W2898192015 cites W2130436333 @default.
• W2898192015 cites W2131834203 @default.
• W2898192015 cites W2132454232 @default.
• W2898192015 cites W2136609531 @default.
• W2898192015 cites W2139303729 @default.
• W2898192015 cites W2139793230 @default.
• W2898192015 cites W2139813765 @default.
• W2898192015 cites W2141979454 @default.
• W2898192015 cites W2147573811 @default.
• W2898192015 cites W2148334526 @default.
• W2898192015 cites W2150069211 @default.

• next