FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898197261> ?p ?o ?g. }

• W2898197261 endingPage "viii252" @default.
• W2898197261 startingPage "viii251" @default.
• W2898197261 abstract "Background: It has been reported that bacteria can metabolize gemcitabine (gem) into its inactive and contribute to the drug resistance. It was also reported that the resistance was abrogated by cotreatment with antibiotics [Geller LT, et al. Science 2017], in which, many of human pancreatic ductal adenocarcinoma samples contained causal bacteria which potentially mediates tumor resistance to gem. We therefore hypothesized the use of antibiotics may affect clinical outcomes of gem therapy in patients (pts) with pancreatic cancer (PC). Methods: We retrospectively investigated pts with advanced PC who were treated with gem alone as first-line treatment in our single institute between 2009 and 2017. The association of use of antibiotics before gem treatment with progression-free survival (PFS) and overall survival (OS) was analyzed using Cox proportional hazards model and log-rank test. Results: One hundred twenty-four pts were treated with gem alone as first-line therapy and had the following characteristics: median age of 72yrs, 59% male, 39%/54%/4%/3% for PS0/1/2/3, 53%/26%/19% for primary tumor of head/body/tail, median PFS of 3.4 months, and median OS of 7.7 months. In 124 pts, 59% used antibiotics before treatment with gem. One hundred pts discontinued due to disease progression, while 24 pts due to toxicity or pts’ wish. Pts who received antibiotics had significantly longer PFS than pts who did not receive antibiotics (4.2 vs. 2.1 months, HR 0.64, 95%CI 0.43-0.96, P = 0.029). The association was not statistically significant after multivariate analysis adjusted for PS, tumor location, and number of metastatic sites (HR 0.73, 95%CI 0.45-1.17, P = 0.19). Median OS was numerically longer in pts with use of antibiotics than in pts without antibiotics (8.0 vs. 5.5 months). Conclusions: Our study indicated that antibiotic use before gem therapy was associated with favorable outcome in pts with advanced PC treated with gem. These findings warrant further exploratory studies and suggest scientific approach to identify antibiotics as an enhancer for gem. Legal entity responsible for the study: Takako Eguchi Nakajima. Funding: Has not received any funding. Disclosure: Y. Sunakawa: Honoraria: Taiho Pharmaceutical, Chugai Pharma, Yakult Honsha, Takeda, Merck Serono, Bayer Yakuhin, Eli Lilly Japan, Sanofi. N. Izawa: Honoraria: Taiho Pharmaceutical Co., Ltd., Merck Serono Co., Ltd. T.E. Nakajima: Personal financial interests: Eli Lilly, Sanofi, Chugai, Sawai, Bayer, Bristol, Taiho, Merck, Ono, Takeda, Mochida, MSD; Institutional financial interests: Ono, Taiho, A2 Health Care, JCRO, Daiichi-Sankyo, Mediscience Planning. All other authors have declared no conflicts of interest." @default.
• W2898197261 created "2018-11-02" @default.
• W2898197261 creator A5000250708 @default.
• W2898197261 creator A5001214587 @default.
• W2898197261 creator A5005246006 @default.
• W2898197261 creator A5013766133 @default.
• W2898197261 creator A5013994958 @default.
• W2898197261 creator A5024787748 @default.
• W2898197261 creator A5040212443 @default.
• W2898197261 creator A5044194892 @default.
• W2898197261 creator A5060570178 @default.
• W2898197261 creator A5084744867 @default.
• W2898197261 date "2018-10-01" @default.
• W2898197261 modified "2023-10-02" @default.
• W2898197261 title "Antibiotics may enhance the efficacy of gemcitabine treatment for advanced pancreatic cancer" @default.
• W2898197261 doi "https://doi.org/10.1093/annonc/mdy282.121" @default.
• W2898197261 hasPublicationYear "2018" @default.
• W2898197261 type Work @default.
• W2898197261 sameAs 2898197261 @default.
• W2898197261 citedByCount "3" @default.
• W2898197261 countsByYear W28981972612022 @default.
• W2898197261 countsByYear W28981972612023 @default.
• W2898197261 crossrefType "journal-article" @default.
• W2898197261 hasAuthorship W2898197261A5000250708 @default.
• W2898197261 hasAuthorship W2898197261A5001214587 @default.
• W2898197261 hasAuthorship W2898197261A5005246006 @default.
• W2898197261 hasAuthorship W2898197261A5013766133 @default.
• W2898197261 hasAuthorship W2898197261A5013994958 @default.
• W2898197261 hasAuthorship W2898197261A5024787748 @default.
• W2898197261 hasAuthorship W2898197261A5040212443 @default.
• W2898197261 hasAuthorship W2898197261A5044194892 @default.
• W2898197261 hasAuthorship W2898197261A5060570178 @default.
• W2898197261 hasAuthorship W2898197261A5084744867 @default.
• W2898197261 hasBestOaLocation W28981972611 @default.
• W2898197261 hasConcept C121608353 @default.
• W2898197261 hasConcept C126322002 @default.
• W2898197261 hasConcept C141071460 @default.
• W2898197261 hasConcept C143998085 @default.
• W2898197261 hasConcept C2776694085 @default.
• W2898197261 hasConcept C2780210213 @default.
• W2898197261 hasConcept C2780258809 @default.
• W2898197261 hasConcept C2780739268 @default.
• W2898197261 hasConcept C501593827 @default.
• W2898197261 hasConcept C50382708 @default.
• W2898197261 hasConcept C71924100 @default.
• W2898197261 hasConcept C86803240 @default.
• W2898197261 hasConcept C89423630 @default.
• W2898197261 hasConcept C90924648 @default.
• W2898197261 hasConceptScore W2898197261C121608353 @default.
• W2898197261 hasConceptScore W2898197261C126322002 @default.
• W2898197261 hasConceptScore W2898197261C141071460 @default.
• W2898197261 hasConceptScore W2898197261C143998085 @default.
• W2898197261 hasConceptScore W2898197261C2776694085 @default.
• W2898197261 hasConceptScore W2898197261C2780210213 @default.
• W2898197261 hasConceptScore W2898197261C2780258809 @default.
• W2898197261 hasConceptScore W2898197261C2780739268 @default.
• W2898197261 hasConceptScore W2898197261C501593827 @default.
• W2898197261 hasConceptScore W2898197261C50382708 @default.
• W2898197261 hasConceptScore W2898197261C71924100 @default.
• W2898197261 hasConceptScore W2898197261C86803240 @default.
• W2898197261 hasConceptScore W2898197261C89423630 @default.
• W2898197261 hasConceptScore W2898197261C90924648 @default.
• W2898197261 hasLocation W28981972611 @default.
• W2898197261 hasOpenAccess W2898197261 @default.
• W2898197261 hasPrimaryLocation W28981972611 @default.
• W2898197261 hasRelatedWork W1969578744 @default.
• W2898197261 hasRelatedWork W2005537476 @default.
• W2898197261 hasRelatedWork W2319496893 @default.
• W2898197261 hasRelatedWork W2349340765 @default.
• W2898197261 hasRelatedWork W2365966720 @default.
• W2898197261 hasRelatedWork W2370585970 @default.
• W2898197261 hasRelatedWork W2376347278 @default.
• W2898197261 hasRelatedWork W2419408601 @default.
• W2898197261 hasRelatedWork W3196960728 @default.
• W2898197261 hasRelatedWork W4307429747 @default.
• W2898197261 hasVolume "29" @default.
• W2898197261 isParatext "false" @default.
• W2898197261 isRetracted "false" @default.
• W2898197261 magId "2898197261" @default.
• W2898197261 workType "article" @default.