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- W2898220812 abstract "FBXW7 (F-box and WD repeat domain containing-7) is a tumor suppressor protein that regulates the degradation of various oncoproteins in several malignancies. However, limited information is available regarding FBXW7 mutations in non-small-cell lung cancer. While the genetic variability of FBXW7 mutation NSCLC patients is unclear. The aim of this study is to investigate mutations and prognosis of NSCLC harboring FBXW7 mutations. A total of 229 patients with non-small-cell lung cancer were recruited between July 2012 and December 2015. The status of FBXW7 mutation and other genes were detected by next generation sequencing. FBXW7 gene mutation rate was 3.06% (7/229) in non-small cell lung cancer, including G66Efs*55 (1 patient), I487Sfs*23 (1 patient), S668Vfs*39 (1 patient), G493E (1 patient), R49W(1 patient), S550Efs*26 (1 patient) and R505L (1 patient), and median overall survival (OS) for these patients was 10.0 months. Among them, all patients were FBXW7 gene with co-occurring mutation. Briefly, patients with (n=2) or without (n=5) co-occurring EGFR mutations had a median OS of 13.5 months and 10.0 months respectively (P=0.56); patients with (n=5) or without (n=2) co-occurring TP53 mutations had a median OS of 6.0 months and 17.5 months respectively (P=0.27); patients with (n=2) or without (n=5) co-occurring PIK3CA mutations had a median OS of 8.0 months and 14.0 months respectively (P=0.43); patients with (n=3) or without (n=4) co-occurring STK11 mutations had a median OS of 4.0 months and 17.5 months respectively (P=0.06). FBXW7, normally a tumor suppressor, can act as an oncogene when mutated and may play an important role in the pathogenesis of NSCLC. EGFR, TP53 and PIK3CA gene accompanied may have less correlation with FBXW7 mutation in NSCLC patients. Everolimus may displayed moderated efficacy in patients with FBXW7 mutation. STK11 accompanied mutations might play a worse prognosis in FBXW7 gene mutation NSCLC." @default.
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- W2898220812 date "2018-10-01" @default.
- W2898220812 modified "2023-09-28" @default.
- W2898220812 title "P1.03-32 Molecular Characteristics and Prognosis FBXW7 Mutations in Chinese Non-Small-Cell Lung Cancer Patients" @default.
- W2898220812 doi "https://doi.org/10.1016/j.jtho.2018.08.713" @default.
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