FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898246366> ?p ?o ?g. }

• W2898246366 endingPage "1687" @default.
• W2898246366 startingPage "1676" @default.
• W2898246366 abstract "Ca2+ influx through Cav1.4 L-type Ca2+ channels supports the sustained release of glutamate from photoreceptor synaptic terminals in darkness, a process that is critical for vision. Consistent with this role, Cav1.4 exhibits weak Ca2+-dependent inactivation (CDI)—a negative feedback regulation mediated by Ca2+-bound calmodulin (CaM). CaM binds to a conserved IQ domain in the proximal C-terminal domain of Cav channels, but in Cav1.4, a C-terminal modulatory domain (CTM) disrupts interactions with CaM. Exon 47 encodes a portion of the CTM and is deleted in a Cav1.4 splice variant (Cav1.4Δex47) that is highly expressed in the human retina. Cav1.4Δex47 exhibits CDI and enhanced voltage-dependent activation, similar to that caused by a mutation that is associated with congenital stationary night blindness type 2, in which the CTM is deleted (K1591X). The presence of CDI and very negative activation thresholds in a naturally occurring variant of Cav1.4 are perplexing considering that these properties are expected to be maladaptive for visual signaling and result in night blindness in the case of K1591X. Here we show that Cav1.4Δex47 and K1591X exhibit fundamental differences in their regulation by CaM. In Cav1.4Δex47, CDI requires both the N-terminal (N lobe) and C-terminal (C lobe) lobes of CaM to bind Ca2+, whereas CDI in K1591X is driven mainly by Ca2+ binding to the C lobe. Moreover, the CaM N lobe causes a Ca2+-dependent enhancement of activation of Cav1.4Δex47 but not K1591X. We conclude that the residual CTM in Cav1.4Δex47 enables a form of CaM N lobe regulation of activation and CDI that is absent in K1591X. Interaction with the N lobe of CaM, which is more sensitive to global elevations in cytosolic Ca2+ than the C lobe, may allow Cav1.4Δex47 to be modulated by a wider range of synaptic Ca2+ concentrations than K1591X; this may distinguish the normal physiological function of Cav1.4Δex47 from the pathological consequences of K1591X." @default.
• W2898246366 created "2018-11-02" @default.
• W2898246366 creator A5042328864 @default.
• W2898246366 creator A5078900835 @default.
• W2898246366 creator A5090160611 @default.
• W2898246366 date "2018-10-24" @default.
• W2898246366 modified "2023-10-17" @default.
• W2898246366 title "Splicing of an automodulatory domain in Cav1.4 Ca2+ channels confers distinct regulation by calmodulin" @default.
• W2898246366 cites W1523938232 @default.
• W2898246366 cites W1544777143 @default.
• W2898246366 cites W1589880923 @default.
• W2898246366 cites W1977584840 @default.
• W2898246366 cites W1978225079 @default.
• W2898246366 cites W1982797011 @default.
• W2898246366 cites W1984900040 @default.
• W2898246366 cites W1984987102 @default.
• W2898246366 cites W1990768235 @default.
• W2898246366 cites W1992096875 @default.
• W2898246366 cites W1993188952 @default.
• W2898246366 cites W1997424855 @default.
• W2898246366 cites W2013076639 @default.
• W2898246366 cites W2015593651 @default.
• W2898246366 cites W2022582268 @default.
• W2898246366 cites W2023631681 @default.
• W2898246366 cites W2030068415 @default.
• W2898246366 cites W2038049156 @default.
• W2898246366 cites W2054539671 @default.
• W2898246366 cites W2057269307 @default.
• W2898246366 cites W2057434588 @default.
• W2898246366 cites W2066290601 @default.
• W2898246366 cites W2073645208 @default.
• W2898246366 cites W2078470782 @default.
• W2898246366 cites W2079419321 @default.
• W2898246366 cites W2081258455 @default.
• W2898246366 cites W2087062865 @default.
• W2898246366 cites W2095470391 @default.
• W2898246366 cites W2096871416 @default.
• W2898246366 cites W2097659472 @default.
• W2898246366 cites W2103224021 @default.
• W2898246366 cites W2105689617 @default.
• W2898246366 cites W2125318318 @default.
• W2898246366 cites W2126063601 @default.
• W2898246366 cites W2126379315 @default.
• W2898246366 cites W2131435989 @default.
• W2898246366 cites W2138447329 @default.
• W2898246366 cites W2143125286 @default.
• W2898246366 cites W2172450920 @default.
• W2898246366 cites W2195414185 @default.
• W2898246366 cites W2398048693 @default.
• W2898246366 doi "https://doi.org/10.1085/jgp.201812140" @default.
• W2898246366 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6279360" @default.
• W2898246366 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30355583" @default.
• W2898246366 hasPublicationYear "2018" @default.
• W2898246366 type Work @default.
• W2898246366 sameAs 2898246366 @default.
• W2898246366 citedByCount "8" @default.
• W2898246366 countsByYear W28982463662020 @default.
• W2898246366 countsByYear W28982463662021 @default.
• W2898246366 countsByYear W28982463662022 @default.
• W2898246366 crossrefType "journal-article" @default.
• W2898246366 hasAuthorship W2898246366A5042328864 @default.
• W2898246366 hasAuthorship W2898246366A5078900835 @default.
• W2898246366 hasAuthorship W2898246366A5090160611 @default.
• W2898246366 hasBestOaLocation W28982463661 @default.
• W2898246366 hasConcept C104292427 @default.
• W2898246366 hasConcept C104317684 @default.
• W2898246366 hasConcept C169760540 @default.
• W2898246366 hasConcept C178790620 @default.
• W2898246366 hasConcept C181199279 @default.
• W2898246366 hasConcept C185592680 @default.
• W2898246366 hasConcept C18699975 @default.
• W2898246366 hasConcept C194583182 @default.
• W2898246366 hasConcept C201571599 @default.
• W2898246366 hasConcept C2776972302 @default.
• W2898246366 hasConcept C29688787 @default.
• W2898246366 hasConcept C36823959 @default.
• W2898246366 hasConcept C501734568 @default.
• W2898246366 hasConcept C519063684 @default.
• W2898246366 hasConcept C54355233 @default.
• W2898246366 hasConcept C55493867 @default.
• W2898246366 hasConcept C62478195 @default.
• W2898246366 hasConcept C86803240 @default.
• W2898246366 hasConcept C95444343 @default.
• W2898246366 hasConceptScore W2898246366C104292427 @default.
• W2898246366 hasConceptScore W2898246366C104317684 @default.
• W2898246366 hasConceptScore W2898246366C169760540 @default.
• W2898246366 hasConceptScore W2898246366C178790620 @default.
• W2898246366 hasConceptScore W2898246366C181199279 @default.
• W2898246366 hasConceptScore W2898246366C185592680 @default.
• W2898246366 hasConceptScore W2898246366C18699975 @default.
• W2898246366 hasConceptScore W2898246366C194583182 @default.
• W2898246366 hasConceptScore W2898246366C201571599 @default.
• W2898246366 hasConceptScore W2898246366C2776972302 @default.
• W2898246366 hasConceptScore W2898246366C29688787 @default.
• W2898246366 hasConceptScore W2898246366C36823959 @default.
• W2898246366 hasConceptScore W2898246366C501734568 @default.
• W2898246366 hasConceptScore W2898246366C519063684 @default.
• W2898246366 hasConceptScore W2898246366C54355233 @default.

• next