FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898246781> ?p ?o ?g. }

• W2898246781 abstract "Neuroblastoma (NB) is the most common pediatric solid tumor that originates from neural crest-derived sympathoadrenal precursor cells that are committed to development of sympathetic nervous system. The well differentiated histological phenotype of NB tumor cells has been reportedly associated with favorable patient outcome. Retinoic acid (RA) can effectively induce NB cell differentiation, thereby being used in the clinic as a treatment agent for inducing the differentiation of high-risk NB. However, the underlying molecular mechanisms of regulating differentiation remain elusive.The correlation between clinical characteristics, survival and the deubiquitinating enzyme ubiquitin C-terminal hydrolase 1 (UCHL1) expression were assessed using a neuroblastic tumor tissue microarray, and then validated in three independent patient datasets. The different expression of UCHL1 in ganglioneuroblastoma, ganglioneuroma and NB was detected by immunohistochemistry, mass spectra and immunoblotting analysis, and the correlation between UCHL1 expression and the differentiated histology was analyzed, which was also validated in three independent patient datasets. Furthermore, the roles of UCHL1 in NB cell differentiation and proliferation and the underlying mechanisms were studied by using short hairpin RNA and its inhibitor LDN57444 in vitro.Based on our neuroblastic tumor tissue microarrays and three independent validation datasets (Oberthuer, Versteeg and Seeger), we identified that UCHL1 served as a prognostic marker for better clinical outcome in NB. We further demonstrated that high UCHL1 expression was associated with NB differentiation, indicated by higher UCHL1 expression in ganglioneuroblastomas/ganglioneuromas and well-differentiated NB than poorly differentiated NB, and the positive correlation between UCHL1 and differentiation markers. As expected, inhibiting UCHL1 by knockdown or LDN57444 could significantly inhibit RA-induced neural differentiation of NB tumor cells, characterized by decreased neurite outgrowth and neural differentiation markers. This effect of UCHL1 was associated with positively regulating RA-induced AKT and ERK1/2 signaling activation. What's more, knockdown of UCHL1 conferred resistance to RA-induced growth arrest.Our findings identify a pivotal role of UCHL1 in NB cell differentiation and as a prognostic marker for survival in patients with NB, potentially providing a novel therapeutic target for NB." @default.
• W2898246781 created "2018-11-02" @default.
• W2898246781 creator A5011322561 @default.
• W2898246781 creator A5013884567 @default.
• W2898246781 creator A5020088480 @default.
• W2898246781 creator A5026393313 @default.
• W2898246781 creator A5053566490 @default.
• W2898246781 creator A5063126731 @default.
• W2898246781 creator A5068070422 @default.
• W2898246781 creator A5074089354 @default.
• W2898246781 creator A5074339191 @default.
• W2898246781 creator A5079438390 @default.
• W2898246781 creator A5087475349 @default.
• W2898246781 creator A5089096739 @default.
• W2898246781 date "2018-10-25" @default.
• W2898246781 modified "2023-10-14" @default.
• W2898246781 title "The deubiquitinating enzyme UCHL1 is a favorable prognostic marker in neuroblastoma as it promotes neuronal differentiation" @default.
• W2898246781 cites W1653631888 @default.
• W2898246781 cites W1894057315 @default.
• W2898246781 cites W1926885922 @default.
• W2898246781 cites W1964520872 @default.
• W2898246781 cites W1967098715 @default.
• W2898246781 cites W1977889350 @default.
• W2898246781 cites W1986441249 @default.
• W2898246781 cites W2000577272 @default.
• W2898246781 cites W2002156115 @default.
• W2898246781 cites W2015751107 @default.
• W2898246781 cites W2018393684 @default.
• W2898246781 cites W2047200931 @default.
• W2898246781 cites W2051556946 @default.
• W2898246781 cites W2057527139 @default.
• W2898246781 cites W2059531568 @default.
• W2898246781 cites W2063960043 @default.
• W2898246781 cites W2068931555 @default.
• W2898246781 cites W2071793574 @default.
• W2898246781 cites W2082232396 @default.
• W2898246781 cites W2089505157 @default.
• W2898246781 cites W2091910580 @default.
• W2898246781 cites W2095849686 @default.
• W2898246781 cites W2096600031 @default.
• W2898246781 cites W2101362932 @default.
• W2898246781 cites W2106713259 @default.
• W2898246781 cites W2114720222 @default.
• W2898246781 cites W2118071133 @default.
• W2898246781 cites W2126352399 @default.
• W2898246781 cites W2126882311 @default.
• W2898246781 cites W2130925781 @default.
• W2898246781 cites W2132855064 @default.
• W2898246781 cites W2137092630 @default.
• W2898246781 cites W2139752108 @default.
• W2898246781 cites W2144488343 @default.
• W2898246781 cites W2151115238 @default.
• W2898246781 cites W2152420890 @default.
• W2898246781 cites W2165256106 @default.
• W2898246781 cites W2168919863 @default.
• W2898246781 cites W2220838850 @default.
• W2898246781 cites W2519390626 @default.
• W2898246781 cites W2744683708 @default.
• W2898246781 cites W2750470970 @default.
• W2898246781 cites W2766223190 @default.
• W2898246781 doi "https://doi.org/10.1186/s13046-018-0931-z" @default.
• W2898246781 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6203192" @default.
• W2898246781 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30359286" @default.
• W2898246781 hasPublicationYear "2018" @default.
• W2898246781 type Work @default.
• W2898246781 sameAs 2898246781 @default.
• W2898246781 citedByCount "28" @default.
• W2898246781 countsByYear W28982467812019 @default.
• W2898246781 countsByYear W28982467812020 @default.
• W2898246781 countsByYear W28982467812021 @default.
• W2898246781 countsByYear W28982467812022 @default.
• W2898246781 countsByYear W28982467812023 @default.
• W2898246781 crossrefType "journal-article" @default.
• W2898246781 hasAuthorship W2898246781A5011322561 @default.
• W2898246781 hasAuthorship W2898246781A5013884567 @default.
• W2898246781 hasAuthorship W2898246781A5020088480 @default.
• W2898246781 hasAuthorship W2898246781A5026393313 @default.
• W2898246781 hasAuthorship W2898246781A5053566490 @default.
• W2898246781 hasAuthorship W2898246781A5063126731 @default.
• W2898246781 hasAuthorship W2898246781A5068070422 @default.
• W2898246781 hasAuthorship W2898246781A5074089354 @default.
• W2898246781 hasAuthorship W2898246781A5074339191 @default.
• W2898246781 hasAuthorship W2898246781A5079438390 @default.
• W2898246781 hasAuthorship W2898246781A5087475349 @default.
• W2898246781 hasAuthorship W2898246781A5089096739 @default.
• W2898246781 hasBestOaLocation W28982467811 @default.
• W2898246781 hasConcept C102658986 @default.
• W2898246781 hasConcept C104317684 @default.
• W2898246781 hasConcept C113246987 @default.
• W2898246781 hasConcept C126749454 @default.
• W2898246781 hasConcept C127716648 @default.
• W2898246781 hasConcept C142724271 @default.
• W2898246781 hasConcept C148738053 @default.
• W2898246781 hasConcept C153911025 @default.
• W2898246781 hasConcept C173396325 @default.
• W2898246781 hasConcept C193270364 @default.
• W2898246781 hasConcept C196843134 @default.
• W2898246781 hasConcept C202751555 @default.
• W2898246781 hasConcept C203014093 @default.
• W2898246781 hasConcept C204232928 @default.

• next