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- W2898253703 abstract "Pin1 belongs to the family of the peptidyl-prolyl cis-trans isomerase (PPIase), which is a class of enzymes that catalyze the cis/trans isomerization of the Proline residue. Pin1 is unique and only catalyzes the phosphorylated Serine/Threonine-Proline (S/T-P) motifs of a subset of proteins. Since the discovery of Pin1 as a key protein in cell cycle regulation, it has been implicated in numerous diseases, ranging from cancer to neurodegenerative diseases. The main features of Pin1 lies in its two main domains: the WW (two conserved tryptophan) domain and the PPIase domain. Despite extensive studies trying to understand the mechanisms of Pin1 functions, how these two domains contribute to the biological roles of Pin1 in cellular signaling requires more investigations. The WW domain of Pin1 is known to have a higher affinity to its substrate than that of the PPIase domain. Yet, the WW domain seems to prefer the trans configuration of phosphorylated S/T-P motif, while the PPIase catalyzes the cis to trans isomerasion. Such contradicting information has generated much confusion as to the actual mechanism of Pin1 function. In addition, dynamic allostery has been suggested to be important for Pin1 function. Henceforth, in this review, we will be looking at the progress made in understanding the function of Pin1, and how these understandings can aid us in overcoming the diseases implicated by Pin1 such as cancer during drug development." @default.
- W2898253703 created "2018-11-02" @default.
- W2898253703 creator A5004431867 @default.
- W2898253703 creator A5072699872 @default.
- W2898253703 date "2018-10-25" @default.
- W2898253703 modified "2023-10-06" @default.
- W2898253703 title "Gears-In-Motion: The Interplay of WW and PPIase Domains in Pin1" @default.
- W2898253703 cites W1541944730 @default.
- W2898253703 cites W1580994903 @default.
- W2898253703 cites W190233380 @default.
- W2898253703 cites W1964439982 @default.
- W2898253703 cites W1968069432 @default.
- W2898253703 cites W1970446261 @default.
- W2898253703 cites W1974698351 @default.
- W2898253703 cites W1977911183 @default.
- W2898253703 cites W1978144511 @default.
- W2898253703 cites W197969011 @default.
- W2898253703 cites W1979702454 @default.
- W2898253703 cites W1981149222 @default.
- W2898253703 cites W1982137838 @default.
- W2898253703 cites W1983871031 @default.
- W2898253703 cites W1985131241 @default.
- W2898253703 cites W1988364408 @default.
- W2898253703 cites W1989895869 @default.
- W2898253703 cites W1996969987 @default.
- W2898253703 cites W1997341376 @default.
- W2898253703 cites W1997533858 @default.
- W2898253703 cites W1998093640 @default.
- W2898253703 cites W1998765326 @default.
- W2898253703 cites W1998983060 @default.
- W2898253703 cites W2002285022 @default.
- W2898253703 cites W2007217024 @default.
- W2898253703 cites W2010637511 @default.
- W2898253703 cites W2012745341 @default.
- W2898253703 cites W2013334458 @default.
- W2898253703 cites W2016132261 @default.
- W2898253703 cites W2017216357 @default.
- W2898253703 cites W2017387272 @default.
- W2898253703 cites W2020527014 @default.
- W2898253703 cites W2021034213 @default.
- W2898253703 cites W2023604759 @default.
- W2898253703 cites W2023711480 @default.
- W2898253703 cites W2027253705 @default.
- W2898253703 cites W2033328080 @default.
- W2898253703 cites W2034630094 @default.
- W2898253703 cites W2035045046 @default.
- W2898253703 cites W2035586950 @default.
- W2898253703 cites W2040005341 @default.
- W2898253703 cites W2042076653 @default.
- W2898253703 cites W2042964041 @default.
- W2898253703 cites W2043035995 @default.
- W2898253703 cites W2043580883 @default.
- W2898253703 cites W2043763280 @default.
- W2898253703 cites W2043764521 @default.
- W2898253703 cites W2044098205 @default.
- W2898253703 cites W2045295833 @default.
- W2898253703 cites W2046518075 @default.
- W2898253703 cites W2048325051 @default.
- W2898253703 cites W2050000741 @default.
- W2898253703 cites W2050779639 @default.
- W2898253703 cites W2053437843 @default.
- W2898253703 cites W2057396381 @default.
- W2898253703 cites W2059977521 @default.
- W2898253703 cites W2062371417 @default.
- W2898253703 cites W2063530729 @default.
- W2898253703 cites W2072859071 @default.
- W2898253703 cites W2075125140 @default.
- W2898253703 cites W2075530203 @default.
- W2898253703 cites W2077785304 @default.
- W2898253703 cites W2078189636 @default.
- W2898253703 cites W2078864507 @default.
- W2898253703 cites W2082747164 @default.
- W2898253703 cites W2083622112 @default.
- W2898253703 cites W2085347260 @default.
- W2898253703 cites W2087953279 @default.
- W2898253703 cites W2089161481 @default.
- W2898253703 cites W2090248730 @default.
- W2898253703 cites W2092492689 @default.
- W2898253703 cites W2095001952 @default.
- W2898253703 cites W2095539974 @default.
- W2898253703 cites W2098426286 @default.
- W2898253703 cites W2103451229 @default.
- W2898253703 cites W2103629368 @default.
- W2898253703 cites W2113675798 @default.
- W2898253703 cites W2116142935 @default.
- W2898253703 cites W2116528837 @default.
- W2898253703 cites W2122779132 @default.
- W2898253703 cites W2124353932 @default.
- W2898253703 cites W2124842862 @default.
- W2898253703 cites W2126043496 @default.
- W2898253703 cites W2126946512 @default.
- W2898253703 cites W2130861650 @default.
- W2898253703 cites W2132178599 @default.
- W2898253703 cites W2132385852 @default.
- W2898253703 cites W2132527654 @default.
- W2898253703 cites W2133945703 @default.
- W2898253703 cites W2134164899 @default.
- W2898253703 cites W2135656292 @default.
- W2898253703 cites W2138380498 @default.
- W2898253703 cites W2139936160 @default.