FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898254312> ?p ?o ?g. }

• W2898254312 endingPage "S788" @default.
• W2898254312 startingPage "S788" @default.
• W2898254312 abstract "Low-dose computed tomography lung cancer screening is recommended by US guidelines. New solid nodules are regularly found in incidence screening rounds and have a higher lung cancer probability than baseline nodules. Contrary to baseline nodules, new nodules develop within a known screening interval (time between previous screen and new nodule detection). There is limited evidence concerning the impact of varying screening interval lengths on new solid nodules. In the randomized Dutch-Belgian Lung Cancer Screening (NELSON) Trial, 7,557 participants underwent baseline screening. Three incidence rounds took place after intervals of 12months, 24months and 30months respectively and follow-up intervals ranged from 2-12months. We included solid non-calcified nodules registered after baseline as new and not visible in retrospect. Using logistic regression, screening interval length was assessed as predictor for lung cancer whilst adjusting for nodule size. The correlation of screening interval length and new nodule size was assessed with Spearman's rank correlation. Discriminative performance for lung cancer was quantified as area under the receiver operating characteristics curve (AUC). Overall, 1,130 new solid nodules were included with 6% being lung cancer. Of the nodules, 13% were detected after a screening interval of <10months, 28% after 10-14months, 4% after 15-21months, 37% after 22-26months, and 20% after >26months. While the proportion of new solid nodules that subsequently resolved until first follow-up decreased with longer screening interval (76%, 70%, 59%, 57%, 41% respectively, p<0.001), the lung cancer proportion significantly increased (2%, 3%, 3%, 7%, 11% respectively, p=0.001). The screening interval length was a significant predictor for lung cancer when assessed in all nodules (p=0.018). However, there was no significant association when only assessed in nodules that persisted on first follow-up (p=0.223). Compared to benign nodules, lung cancer size at initial detection correlated stronger with screening interval length (spearman's rho 0.106 vs. 0.320) and the discriminative performance of volume for lung cancer increased with screening interval length (AUC: 0.71 at 10-14months vs. 0.84 at >26months). Comparing malignant nodules detected after 10-14months, 22-26months or >26months, the proportion of stage IA lung cancers decreased (73%, 63%, 39% respectively, p=0.139) and all IIIb/IV cancers were found after >22months. The longer the screening interval prior to new nodule detection, the lower the nodule’s probability to resolve and the higher the nodule’s lung cancer probability. While a longer screening interval might facilitate the discrimination between benign and malignant new solid nodules, there was a trend for less favorable staging." @default.
• W2898254312 created "2018-11-02" @default.
• W2898254312 creator A5003828219 @default.
• W2898254312 creator A5005026444 @default.
• W2898254312 creator A5024082845 @default.
• W2898254312 creator A5032695982 @default.
• W2898254312 creator A5056720851 @default.
• W2898254312 creator A5078025092 @default.
• W2898254312 date "2018-10-01" @default.
• W2898254312 modified "2023-10-17" @default.
• W2898254312 title "P2.11-24 Impact of Screening Interval Length on New Nodules Detected in Incidence Rounds of CT Lung Cancer Screening: the NELSON Trial" @default.
• W2898254312 doi "https://doi.org/10.1016/j.jtho.2018.08.1371" @default.
• W2898254312 hasPublicationYear "2018" @default.
• W2898254312 type Work @default.
• W2898254312 sameAs 2898254312 @default.
• W2898254312 citedByCount "1" @default.
• W2898254312 countsByYear W28982543122022 @default.
• W2898254312 crossrefType "journal-article" @default.
• W2898254312 hasAuthorship W2898254312A5003828219 @default.
• W2898254312 hasAuthorship W2898254312A5005026444 @default.
• W2898254312 hasAuthorship W2898254312A5024082845 @default.
• W2898254312 hasAuthorship W2898254312A5032695982 @default.
• W2898254312 hasAuthorship W2898254312A5056720851 @default.
• W2898254312 hasAuthorship W2898254312A5078025092 @default.
• W2898254312 hasBestOaLocation W28982543121 @default.
• W2898254312 hasConcept C121608353 @default.
• W2898254312 hasConcept C126322002 @default.
• W2898254312 hasConcept C126838900 @default.
• W2898254312 hasConcept C151730666 @default.
• W2898254312 hasConcept C2524010 @default.
• W2898254312 hasConcept C2776256026 @default.
• W2898254312 hasConcept C2776731575 @default.
• W2898254312 hasConcept C2777405583 @default.
• W2898254312 hasConcept C2778321237 @default.
• W2898254312 hasConcept C2989005 @default.
• W2898254312 hasConcept C33923547 @default.
• W2898254312 hasConcept C44249647 @default.
• W2898254312 hasConcept C58471807 @default.
• W2898254312 hasConcept C61511704 @default.
• W2898254312 hasConcept C71924100 @default.
• W2898254312 hasConcept C86803240 @default.
• W2898254312 hasConceptScore W2898254312C121608353 @default.
• W2898254312 hasConceptScore W2898254312C126322002 @default.
• W2898254312 hasConceptScore W2898254312C126838900 @default.
• W2898254312 hasConceptScore W2898254312C151730666 @default.
• W2898254312 hasConceptScore W2898254312C2524010 @default.
• W2898254312 hasConceptScore W2898254312C2776256026 @default.
• W2898254312 hasConceptScore W2898254312C2776731575 @default.
• W2898254312 hasConceptScore W2898254312C2777405583 @default.
• W2898254312 hasConceptScore W2898254312C2778321237 @default.
• W2898254312 hasConceptScore W2898254312C2989005 @default.
• W2898254312 hasConceptScore W2898254312C33923547 @default.
• W2898254312 hasConceptScore W2898254312C44249647 @default.
• W2898254312 hasConceptScore W2898254312C58471807 @default.
• W2898254312 hasConceptScore W2898254312C61511704 @default.
• W2898254312 hasConceptScore W2898254312C71924100 @default.
• W2898254312 hasConceptScore W2898254312C86803240 @default.
• W2898254312 hasIssue "10" @default.
• W2898254312 hasLocation W28982543121 @default.
• W2898254312 hasOpenAccess W2898254312 @default.
• W2898254312 hasPrimaryLocation W28982543121 @default.
• W2898254312 hasRelatedWork W1997562593 @default.
• W2898254312 hasRelatedWork W2022897925 @default.
• W2898254312 hasRelatedWork W2028862658 @default.
• W2898254312 hasRelatedWork W2078573701 @default.
• W2898254312 hasRelatedWork W2490755820 @default.
• W2898254312 hasRelatedWork W2754376857 @default.
• W2898254312 hasRelatedWork W2795554946 @default.
• W2898254312 hasRelatedWork W2884191226 @default.
• W2898254312 hasRelatedWork W3094324332 @default.
• W2898254312 hasRelatedWork W3148887182 @default.
• W2898254312 hasVolume "13" @default.
• W2898254312 isParatext "false" @default.
• W2898254312 isRetracted "false" @default.
• W2898254312 magId "2898254312" @default.
• W2898254312 workType "article" @default.