FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898274525> ?p ?o ?g. }

• W2898274525 endingPage "438" @default.
• W2898274525 startingPage "425" @default.
• W2898274525 abstract "Phyllanthus phillyreifolius var. commersonii Müll. Arg is an endemic plant of Mauritius. To date, no study has been performed concerning its polyphenolic profile and pharmacological properties. In this study, a decoction (water), ethyl acetate and methanol extracts of the aerial parts of P. phillyreifolius, obtained from different extraction procedures (maceration and Soxhlet), were studied for antibacterial, antioxidant, anticancer, and enzyme inhibitory properties along with their polyphenolic profile. The ethyl acetate macerated extract showed high antibacterial activity against B. cereus (MIC = 0.293 mg/mL) and E. coli (MIC = 0.417 mg/mL) while S. epidermidis was most susceptible to the ethyl acetate-Soxhlet extract (MIC = 0.521 mg/mL). The methanol-Soxhlet extract displayed the most potent cupric and ferric reducing power, and metal chelating effect, while the macerated methanolic extract was the most effective DPPH and ABTS scavenger, and BChE inhibitor. Only the ethyl acetate-Soxhlet extract exhibited α-glucosidase inhibition. All extracts exhibited a strong anti-tyrosinase activity, which was further investigated by molecular docking and molecular dynamic. After 48 h exposure to the extracts for HeLa cell lines, the ethyl acetate-Soxhlet extract showed the highest inhibition (IC50 = 533.1 μg/mL) while the decoction extract was more cytotoxic to MDA-MB-231 cells (IC50 = 337.4 μg/mL). Treatment of cancer cell lines with all P. phillyreifolius extracts resulted in a time-dependent reduction of cell viability for HeLa and dose-and time-dependent reduction for MDA-MB-231. Gene expression ratio of Bcl-2 to Bax was higher for all Soxhlet-extracts. Total phenolics (TPC) and flavonoids (TFC) content were highest in the decoction and methanol-Soxhlet extract, respectively (122.43 mg GAE/g extract and 31.28 mg RE/g extract, respectively). The extracts were abundant in ellagitannins, although phenolic acids and flavonoids were also detected. Granatin B was detected for the first time in Phyllanthus species. Overall, the aerial parts of P. phillyreifolius exemplify a potent reservoir of bioactive phytochemicals for therapeutic applications." @default.
• W2898274525 created "2018-11-02" @default.
• W2898274525 creator A5016876491 @default.
• W2898274525 creator A5017509411 @default.
• W2898274525 creator A5019739196 @default.
• W2898274525 creator A5025512992 @default.
• W2898274525 creator A5037364115 @default.
• W2898274525 creator A5050824577 @default.
• W2898274525 creator A5051513939 @default.
• W2898274525 creator A5068702842 @default.
• W2898274525 creator A5078887599 @default.
• W2898274525 creator A5079177491 @default.
• W2898274525 creator A5091872974 @default.
• W2898274525 date "2019-01-01" @default.
• W2898274525 modified "2023-10-01" @default.
• W2898274525 title "Pharmacological and polyphenolic profiles of Phyllanthus phillyreifolius var. commersonii Müll. Arg: An unexplored endemic species from Mauritius" @default.
• W2898274525 cites W1839553287 @default.
• W2898274525 cites W1964051600 @default.
• W2898274525 cites W1965909855 @default.
• W2898274525 cites W1967848503 @default.
• W2898274525 cites W1969180242 @default.
• W2898274525 cites W1972568358 @default.
• W2898274525 cites W1976499671 @default.
• W2898274525 cites W1979241826 @default.
• W2898274525 cites W1984833201 @default.
• W2898274525 cites W1986876979 @default.
• W2898274525 cites W1996756181 @default.
• W2898274525 cites W2014965141 @default.
• W2898274525 cites W2017196167 @default.
• W2898274525 cites W2021832765 @default.
• W2898274525 cites W2027423337 @default.
• W2898274525 cites W2028191664 @default.
• W2898274525 cites W2028239405 @default.
• W2898274525 cites W2029149449 @default.
• W2898274525 cites W2029442922 @default.
• W2898274525 cites W2031940521 @default.
• W2898274525 cites W2032669542 @default.
• W2898274525 cites W2034402249 @default.
• W2898274525 cites W2036187997 @default.
• W2898274525 cites W2042438338 @default.
• W2898274525 cites W2050456292 @default.
• W2898274525 cites W2052659659 @default.
• W2898274525 cites W2054881399 @default.
• W2898274525 cites W2055267290 @default.
• W2898274525 cites W2062858834 @default.
• W2898274525 cites W2074498845 @default.
• W2898274525 cites W2074621567 @default.
• W2898274525 cites W2076018948 @default.
• W2898274525 cites W2081045003 @default.
• W2898274525 cites W2081049553 @default.
• W2898274525 cites W2082266446 @default.
• W2898274525 cites W2088931089 @default.
• W2898274525 cites W2091309341 @default.
• W2898274525 cites W2095071219 @default.
• W2898274525 cites W2097072470 @default.
• W2898274525 cites W2104842126 @default.
• W2898274525 cites W2110734939 @default.
• W2898274525 cites W2123691699 @default.
• W2898274525 cites W2123744278 @default.
• W2898274525 cites W2138726051 @default.
• W2898274525 cites W2148798102 @default.
• W2898274525 cites W2157833022 @default.
• W2898274525 cites W2158113006 @default.
• W2898274525 cites W2159011332 @default.
• W2898274525 cites W2167461961 @default.
• W2898274525 cites W2197393377 @default.
• W2898274525 cites W2234688382 @default.
• W2898274525 cites W2260240652 @default.
• W2898274525 cites W2260727529 @default.
• W2898274525 cites W2274874882 @default.
• W2898274525 cites W2324788581 @default.
• W2898274525 cites W2326931786 @default.
• W2898274525 cites W2333981272 @default.
• W2898274525 cites W2336829820 @default.
• W2898274525 cites W2510389934 @default.
• W2898274525 cites W2516213810 @default.
• W2898274525 cites W2541410040 @default.
• W2898274525 cites W2574143384 @default.
• W2898274525 cites W2590989747 @default.
• W2898274525 cites W2592596845 @default.
• W2898274525 cites W2593725575 @default.
• W2898274525 cites W2622143974 @default.
• W2898274525 cites W2731492104 @default.
• W2898274525 cites W2757334107 @default.
• W2898274525 cites W2783059160 @default.
• W2898274525 cites W2786645300 @default.
• W2898274525 cites W2789697804 @default.
• W2898274525 cites W2807880296 @default.
• W2898274525 cites W2808544257 @default.
• W2898274525 cites W2811222402 @default.
• W2898274525 cites W2873903144 @default.
• W2898274525 cites W2885378005 @default.
• W2898274525 cites W2887091014 @default.
• W2898274525 cites W2609831528 @default.
• W2898274525 doi "https://doi.org/10.1016/j.foodres.2018.10.075" @default.
• W2898274525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30599961" @default.
• W2898274525 hasPublicationYear "2019" @default.
• W2898274525 type Work @default.

• next