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• W2898276064 endingPage "1893" @default.
• W2898276064 startingPage "1879" @default.
• W2898276064 abstract "SZNF (Sus scrofa zinc finger CCHC domain containing 3) is a post-transcription regulation factor, belonging to CCHC zinc finger proteins. Cyadox is a novel quinoxaline drug with antibacterial and growth promotion effects. In this study, we investigated the pharmacological mechanism of cyadox mediated by SZNF. Firstly, signaling pathways related to cyadox-induced SZNF expression were studied. The results showed that the mRNA level of SZNF reached the peak as early as 4 h after 2 μM cyadox treatment in swine hepatocytes. Several signaling pathways, including JAK2/STAT1, PI3K/Akt, TGF-β/Smad3 and p38, might play critical roles in regulation of SZNF. The JAK2/STAT1, JAK2/PI3K/Akt, PI3K/Akt and myD88 & TAK1 & ASK1 /P38 signaling pathways were firstly activated after cyadox treatment in swine hepatocyte, the TGF-β/Smad3 signaling pathway was activated later. Then given the characteristic of RNA binding of CCHC zinc finger proteins, the target mRNAs binding with SZNF were detected by RNA immunoprecipitation coupled to sequencing (RIP-seq) in PK-15 cells treated with cyadox. The RIP-Seq results showed that the bound mRNAs of 45 genes and 93 genes by SZNF protein were increased and decreased, respectively in cyadox-treated PK-15 cells compared with blank sample. With bioinformatics analysis, we showed that cyadox might exert its antibacterial and growth promotion effect by regulating SZNF-associated target genes in post-transcriptional level, such as genes related to growth (MLXIP, CKS2) and inflammation (LGALS3, PLAU). Thus, our results indicated that SZNF can post-transcriptionally regulate its target genes related to growth and inflammatory in cyadox-treated cells, which may explain the pharmacological mechanism of this drug." @default.
• W2898276064 created "2018-11-02" @default.
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• W2898276064 date "2018-12-01" @default.
• W2898276064 modified "2023-10-16" @default.
• W2898276064 title "Signaling pathways involved in the expression of SZNF and the target genes binding with SZNF related to cyadox" @default.
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• W2898276064 cites W1846279292 @default.
• W2898276064 cites W1944500389 @default.
• W2898276064 cites W1965438129 @default.
• W2898276064 cites W1967443709 @default.
• W2898276064 cites W1969076893 @default.
• W2898276064 cites W1976091561 @default.
• W2898276064 cites W1978567927 @default.
• W2898276064 cites W1980121152 @default.
• W2898276064 cites W1984681113 @default.
• W2898276064 cites W1997609660 @default.
• W2898276064 cites W2006464495 @default.
• W2898276064 cites W2007197579 @default.
• W2898276064 cites W2016907728 @default.
• W2898276064 cites W2017671645 @default.
• W2898276064 cites W2021962516 @default.
• W2898276064 cites W2032417513 @default.
• W2898276064 cites W2032559539 @default.
• W2898276064 cites W2043038936 @default.
• W2898276064 cites W2045679421 @default.
• W2898276064 cites W2046290595 @default.
• W2898276064 cites W2047075711 @default.
• W2898276064 cites W2069227731 @default.
• W2898276064 cites W2076938683 @default.
• W2898276064 cites W2078060476 @default.
• W2898276064 cites W2080892753 @default.
• W2898276064 cites W2080971278 @default.
• W2898276064 cites W2082819541 @default.
• W2898276064 cites W2084566512 @default.
• W2898276064 cites W2088396961 @default.
• W2898276064 cites W2088558015 @default.
• W2898276064 cites W2088735475 @default.
• W2898276064 cites W2100305481 @default.
• W2898276064 cites W2106079993 @default.
• W2898276064 cites W2107444074 @default.
• W2898276064 cites W2130145624 @default.
• W2898276064 cites W2134029960 @default.
• W2898276064 cites W2134979684 @default.
• W2898276064 cites W2141764473 @default.
• W2898276064 cites W2145836265 @default.
• W2898276064 cites W2149194357 @default.
• W2898276064 cites W2154568166 @default.
• W2898276064 cites W2155199896 @default.
• W2898276064 cites W2158751506 @default.
• W2898276064 cites W2159474332 @default.
• W2898276064 cites W2184532485 @default.
• W2898276064 cites W2231303906 @default.
• W2898276064 cites W2285287498 @default.
• W2898276064 cites W2287500581 @default.
• W2898276064 cites W2292259030 @default.
• W2898276064 cites W2324380781 @default.
• W2898276064 cites W2482518480 @default.
• W2898276064 cites W2498400869 @default.
• W2898276064 cites W2532112957 @default.
• W2898276064 cites W2534608553 @default.
• W2898276064 cites W2557634116 @default.
• W2898276064 cites W2570455302 @default.
• W2898276064 cites W2576455489 @default.
• W2898276064 cites W2584979952 @default.
• W2898276064 cites W2609941931 @default.
• W2898276064 cites W2727987799 @default.
• W2898276064 cites W2734685506 @default.
• W2898276064 cites W2746191482 @default.
• W2898276064 cites W2761687106 @default.
• W2898276064 cites W2762727428 @default.
• W2898276064 cites W2764145761 @default.
• W2898276064 cites W2772400483 @default.
• W2898276064 cites W2790207051 @default.
• W2898276064 cites W2797348860 @default.
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• W2898276064 cites W2883121441 @default.
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• W2898276064 doi "https://doi.org/10.1016/j.biopha.2018.09.141" @default.
• W2898276064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30453449" @default.
• W2898276064 hasPublicationYear "2018" @default.
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