Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898282580> ?p ?o ?g. }
- W2898282580 endingPage "2954" @default.
- W2898282580 startingPage "2944" @default.
- W2898282580 abstract "Prostratin, a highly complex diterpene natural product, is a pre-clinical candidate in developing a cure for HIV-1 infection and also a potent and selective inhibitor of several tumors. Despite nearly 40 years of progress, prostratin and related natural products still present formidable challenges for synthetic chemists. Here, we report a total synthesis of (±)-prostratin that proceeds in 23 steps from cyclopentadiene. The synthetic strategy includes rapid assembly of the tricyclic core and highly controlled establishment of the densely functionalized C ring, featuring an array of stereoselective transformations including alkoxide-guided 1,4-additions and cyclopropane formation. This work should enable further explorations of chemical and biological spaces based on prostratin and related natural products." @default.
- W2898282580 created "2018-11-02" @default.
- W2898282580 creator A5014394467 @default.
- W2898282580 creator A5040009629 @default.
- W2898282580 creator A5074916664 @default.
- W2898282580 date "2018-12-01" @default.
- W2898282580 modified "2023-10-16" @default.
- W2898282580 title "Total Synthesis of (±)-Prostratin" @default.
- W2898282580 cites W1968856637 @default.
- W2898282580 cites W1969885626 @default.
- W2898282580 cites W1970055148 @default.
- W2898282580 cites W1978318962 @default.
- W2898282580 cites W1979396258 @default.
- W2898282580 cites W1980814667 @default.
- W2898282580 cites W1982316892 @default.
- W2898282580 cites W1989058130 @default.
- W2898282580 cites W1989247100 @default.
- W2898282580 cites W1990014716 @default.
- W2898282580 cites W1991744668 @default.
- W2898282580 cites W1998595550 @default.
- W2898282580 cites W2000238187 @default.
- W2898282580 cites W2002078737 @default.
- W2898282580 cites W2002923183 @default.
- W2898282580 cites W2004803116 @default.
- W2898282580 cites W2006404271 @default.
- W2898282580 cites W2006485057 @default.
- W2898282580 cites W2010703635 @default.
- W2898282580 cites W2016103682 @default.
- W2898282580 cites W2019975644 @default.
- W2898282580 cites W2020999490 @default.
- W2898282580 cites W2022825352 @default.
- W2898282580 cites W2024258562 @default.
- W2898282580 cites W2026992489 @default.
- W2898282580 cites W2027589189 @default.
- W2898282580 cites W2028808700 @default.
- W2898282580 cites W2031223283 @default.
- W2898282580 cites W2038068805 @default.
- W2898282580 cites W2050784041 @default.
- W2898282580 cites W2051488545 @default.
- W2898282580 cites W2051858712 @default.
- W2898282580 cites W2054944478 @default.
- W2898282580 cites W2056426588 @default.
- W2898282580 cites W2063393833 @default.
- W2898282580 cites W2063810944 @default.
- W2898282580 cites W2066848476 @default.
- W2898282580 cites W2067484231 @default.
- W2898282580 cites W2069113474 @default.
- W2898282580 cites W2077336665 @default.
- W2898282580 cites W2083579184 @default.
- W2898282580 cites W2087595377 @default.
- W2898282580 cites W2092372600 @default.
- W2898282580 cites W2095194715 @default.
- W2898282580 cites W2098433529 @default.
- W2898282580 cites W2101549580 @default.
- W2898282580 cites W2124044015 @default.
- W2898282580 cites W2149096739 @default.
- W2898282580 cites W2150719091 @default.
- W2898282580 cites W2155047247 @default.
- W2898282580 cites W2156767753 @default.
- W2898282580 cites W2175955272 @default.
- W2898282580 cites W2294072397 @default.
- W2898282580 cites W2307703164 @default.
- W2898282580 cites W2320871995 @default.
- W2898282580 cites W2332414803 @default.
- W2898282580 cites W2332672664 @default.
- W2898282580 cites W2333316047 @default.
- W2898282580 cites W240244150 @default.
- W2898282580 cites W2419100559 @default.
- W2898282580 cites W2530233345 @default.
- W2898282580 cites W2548249634 @default.
- W2898282580 cites W2554959673 @default.
- W2898282580 cites W2589416426 @default.
- W2898282580 cites W2750934251 @default.
- W2898282580 cites W2766412438 @default.
- W2898282580 cites W2802290685 @default.
- W2898282580 cites W2808187955 @default.
- W2898282580 cites W2809178676 @default.
- W2898282580 cites W2949470143 @default.
- W2898282580 cites W2950534047 @default.
- W2898282580 cites W2950827946 @default.
- W2898282580 cites W2950909836 @default.
- W2898282580 cites W2951321851 @default.
- W2898282580 cites W2952370527 @default.
- W2898282580 cites W3139625112 @default.
- W2898282580 cites W4210954203 @default.
- W2898282580 cites W4214693616 @default.
- W2898282580 doi "https://doi.org/10.1016/j.chempr.2018.10.002" @default.
- W2898282580 hasPublicationYear "2018" @default.
- W2898282580 type Work @default.
- W2898282580 sameAs 2898282580 @default.
- W2898282580 citedByCount "38" @default.
- W2898282580 countsByYear W28982825802019 @default.
- W2898282580 countsByYear W28982825802020 @default.
- W2898282580 countsByYear W28982825802021 @default.
- W2898282580 countsByYear W28982825802022 @default.
- W2898282580 countsByYear W28982825802023 @default.
- W2898282580 crossrefType "journal-article" @default.
- W2898282580 hasAuthorship W2898282580A5014394467 @default.