Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898287046> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2898287046 endingPage "164" @default.
- W2898287046 startingPage "155" @default.
- W2898287046 abstract "The aim of our research work was to investigate the relative potencies of matrix components of tylosin, a multi-component antibiotic, and establishing a quantitative relationship between content and potency of each component.The potencies of tylosin matrix components were determined by using three bioassay methods. The content of tylosin components (tylosin A, B, C, and D) in different tylosin samples were determined by using high pressure liquid chromatography (HPLC) technique and their theoretical potencies were calculated. Equivalency of theoretical and microbiological potencies for each sample was evaluated using statistical analysis.The highest amount of tylosin B content was found in tylosin phosphate and tartrate (up to 19%). Tylosin D content in all tylosin samples varied in the range of 0.03 to 18.73%. Tylosin A, B, and C showed similar sensitivity to the Kocuria rhizophila, the test organism in agar-diffusion method, while the potency of tylosin D was 39% of A. In the turbidimetric methods by Staphylococcus aureus, tylosin D and B responses to A component were ranged from 22.5 to 22.8% and 77.3 to 79.3%, respectively, while potencies of tylosin C and A were almost equal. The biopotency conversion factors were not resulted to a single factor, due to the different antibacterial activity of tylosin components.Our findings indicated that defining individual limit for the low active matrix components and for the total of other components with similar high activity could improve the accuracy of potency results. Graphical abstract ᅟ." @default.
- W2898287046 created "2018-11-02" @default.
- W2898287046 creator A5015899892 @default.
- W2898287046 creator A5031413654 @default.
- W2898287046 creator A5042267273 @default.
- W2898287046 date "2018-10-25" @default.
- W2898287046 modified "2023-10-11" @default.
- W2898287046 title "Consistency evaluation between matrix components ratio and microbiological potency of tylosin major components" @default.
- W2898287046 cites W14776384 @default.
- W2898287046 cites W1553406526 @default.
- W2898287046 cites W1597121568 @default.
- W2898287046 cites W2001468582 @default.
- W2898287046 cites W2004047381 @default.
- W2898287046 cites W2010376031 @default.
- W2898287046 cites W2010538916 @default.
- W2898287046 cites W2016889457 @default.
- W2898287046 cites W2040407487 @default.
- W2898287046 cites W2042273515 @default.
- W2898287046 cites W2058962533 @default.
- W2898287046 cites W2087714687 @default.
- W2898287046 cites W2102046847 @default.
- W2898287046 cites W2142933316 @default.
- W2898287046 cites W2150175541 @default.
- W2898287046 cites W4245636885 @default.
- W2898287046 cites W4246677544 @default.
- W2898287046 doi "https://doi.org/10.1007/s40199-018-0220-6" @default.
- W2898287046 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6279661" @default.
- W2898287046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30361888" @default.
- W2898287046 hasPublicationYear "2018" @default.
- W2898287046 type Work @default.
- W2898287046 sameAs 2898287046 @default.
- W2898287046 citedByCount "3" @default.
- W2898287046 countsByYear W28982870462021 @default.
- W2898287046 countsByYear W28982870462023 @default.
- W2898287046 crossrefType "journal-article" @default.
- W2898287046 hasAuthorship W2898287046A5015899892 @default.
- W2898287046 hasAuthorship W2898287046A5031413654 @default.
- W2898287046 hasAuthorship W2898287046A5042267273 @default.
- W2898287046 hasBestOaLocation W28982870462 @default.
- W2898287046 hasConcept C179998833 @default.
- W2898287046 hasConcept C185592680 @default.
- W2898287046 hasConcept C202751555 @default.
- W2898287046 hasConcept C2780514615 @default.
- W2898287046 hasConcept C43617362 @default.
- W2898287046 hasConcept C501593827 @default.
- W2898287046 hasConcept C55493867 @default.
- W2898287046 hasConcept C57992300 @default.
- W2898287046 hasConceptScore W2898287046C179998833 @default.
- W2898287046 hasConceptScore W2898287046C185592680 @default.
- W2898287046 hasConceptScore W2898287046C202751555 @default.
- W2898287046 hasConceptScore W2898287046C2780514615 @default.
- W2898287046 hasConceptScore W2898287046C43617362 @default.
- W2898287046 hasConceptScore W2898287046C501593827 @default.
- W2898287046 hasConceptScore W2898287046C55493867 @default.
- W2898287046 hasConceptScore W2898287046C57992300 @default.
- W2898287046 hasFunder F4320322670 @default.
- W2898287046 hasIssue "2" @default.
- W2898287046 hasLocation W28982870461 @default.
- W2898287046 hasLocation W28982870462 @default.
- W2898287046 hasLocation W28982870463 @default.
- W2898287046 hasLocation W28982870464 @default.
- W2898287046 hasOpenAccess W2898287046 @default.
- W2898287046 hasPrimaryLocation W28982870461 @default.
- W2898287046 hasRelatedWork W1963516717 @default.
- W2898287046 hasRelatedWork W1985705595 @default.
- W2898287046 hasRelatedWork W1985899689 @default.
- W2898287046 hasRelatedWork W2030663225 @default.
- W2898287046 hasRelatedWork W2040641639 @default.
- W2898287046 hasRelatedWork W2052182464 @default.
- W2898287046 hasRelatedWork W2129032931 @default.
- W2898287046 hasRelatedWork W2399487744 @default.
- W2898287046 hasRelatedWork W2919292426 @default.
- W2898287046 hasRelatedWork W55092682 @default.
- W2898287046 hasVolume "26" @default.
- W2898287046 isParatext "false" @default.
- W2898287046 isRetracted "false" @default.
- W2898287046 magId "2898287046" @default.
- W2898287046 workType "article" @default.