Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898332370> ?p ?o ?g. }
- W2898332370 startingPage "127" @default.
- W2898332370 abstract "Vitamin D is a prohormone which is converted into its active hormonal form 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in order to activate targeted genes to engender its biological actions. Through both 1,25(OH)2D3-dependent and 1,25(OH)2D3-independent Vitamin D receptor, it actions may involve more than one single receptor and ligand. Vitamin D plays important, pleiotropic role primarily in the maintenance of calcium and phosphate homeostasis by influencing the balance between bone resorption and formation. However, its influence goes far beyond the regulation of mineral homeostasis as diverse activities of Vitamin D assure through both genomic and nongenomic pathways, and it has a physiological value upon vascular health. It has been shown to protect against endothelial dysfunction, vascular smooth muscle cell proliferation and migration, and modulation of the immune system as well as the inflammatory response. In addition, vitamin D has been shown to have systemic effects on insulin resistance, dyslipidemia, and hypertension. Although some vitamin D is essential for cardiovascular health, excess may have detrimental effects, particularly on elastogenesis and inflammation of the arterial wall. This review explores the physiological role of vitamin D in vascular health protection." @default.
- W2898332370 created "2018-11-02" @default.
- W2898332370 creator A5004864045 @default.
- W2898332370 creator A5035842462 @default.
- W2898332370 date "2018-07-01" @default.
- W2898332370 modified "2023-09-25" @default.
- W2898332370 title "Molecular mechanism of vasoprotective effects of Vitamin D" @default.
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