Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898346948> ?p ?o ?g. }
- W2898346948 endingPage "161" @default.
- W2898346948 startingPage "151" @default.
- W2898346948 abstract "Hexachlorobenzene (HCB) is a dioxin-like compound widely distributed and is a weak ligand of the aryl hydrocarbon receptor (AhR). Endometriosis is a disease characterized by growth of endometrial tissue in ectopic sites. Our aim was to investigate the impact of HCB on the endocrine, invasion and inflammatory parameters in a rat endometriosis model surgically induced. Female rats were exposed to HCB (1, 10 and 100 mg/kg b.w.) during 30 days. Results showed that HCB increases endometriotic like-lesions (L) volume in a dose-dependent manner. In L, HCB10 increases microvessel density (immunohistochemistry) and the vascular endothelial growth factor (VEGF), cyclooxygenase-2 (COX-2) and AhR levels (Western Blot), while HCB1 enhances aromatase expression (Western Blot). In addition, in eutopic endometrium (EU), HCB10/HCB100 augments microvessel density, VEGF and MMP-9 expression, while HCB1/HCB10 increases tumor necrosis factor-α (TNF-α) content in peritoneal fluid (ELISA). Interestingly, both L and EU from HCB-treated rats exhibited higher estrogen receptor α (ERα) (immunohistochemistry) and metalloproteases (MMP)-2 and -9 levels (Western Blot), as well as lower progesterone receptor (PR) expression (immunohistochemistry) than in control rats. Environmentally relevant concentrations of HCB could contribute to abnormal changes associated with endometriosis progression and development." @default.
- W2898346948 created "2018-11-02" @default.
- W2898346948 creator A5009182383 @default.
- W2898346948 creator A5015410771 @default.
- W2898346948 creator A5027255197 @default.
- W2898346948 creator A5035819379 @default.
- W2898346948 creator A5050006956 @default.
- W2898346948 creator A5055940705 @default.
- W2898346948 creator A5057276762 @default.
- W2898346948 creator A5061870742 @default.
- W2898346948 creator A5073391787 @default.
- W2898346948 date "2019-01-01" @default.
- W2898346948 modified "2023-10-06" @default.
- W2898346948 title "Exposure to environmental concentrations of hexachlorobenzene induces alterations associated with endometriosis progression in a rat model" @default.
- W2898346948 cites W1770833494 @default.
- W2898346948 cites W1885553031 @default.
- W2898346948 cites W1968334101 @default.
- W2898346948 cites W1975955158 @default.
- W2898346948 cites W1978251716 @default.
- W2898346948 cites W1979924696 @default.
- W2898346948 cites W1981356248 @default.
- W2898346948 cites W1981629790 @default.
- W2898346948 cites W1984281715 @default.
- W2898346948 cites W1992831201 @default.
- W2898346948 cites W1995735732 @default.
- W2898346948 cites W1997710783 @default.
- W2898346948 cites W1998585142 @default.
- W2898346948 cites W2004717157 @default.
- W2898346948 cites W2010311608 @default.
- W2898346948 cites W2013139282 @default.
- W2898346948 cites W2019177342 @default.
- W2898346948 cites W2030199864 @default.
- W2898346948 cites W2031390952 @default.
- W2898346948 cites W2039274017 @default.
- W2898346948 cites W2040095832 @default.
- W2898346948 cites W2041847148 @default.
- W2898346948 cites W2049578567 @default.
- W2898346948 cites W2052024663 @default.
- W2898346948 cites W2052931153 @default.
- W2898346948 cites W2073304812 @default.
- W2898346948 cites W2075715913 @default.
- W2898346948 cites W2078740802 @default.
- W2898346948 cites W2085206489 @default.
- W2898346948 cites W2085585495 @default.
- W2898346948 cites W2090034145 @default.
- W2898346948 cites W2091399668 @default.
- W2898346948 cites W2095115481 @default.
- W2898346948 cites W2097989455 @default.
- W2898346948 cites W2098423712 @default.
- W2898346948 cites W2098755428 @default.
- W2898346948 cites W2107078704 @default.
- W2898346948 cites W2108226327 @default.
- W2898346948 cites W2127353512 @default.
- W2898346948 cites W2134753968 @default.
- W2898346948 cites W2144896292 @default.
- W2898346948 cites W2150232968 @default.
- W2898346948 cites W2157602823 @default.
- W2898346948 cites W2164757963 @default.
- W2898346948 cites W2165650152 @default.
- W2898346948 cites W2165700542 @default.
- W2898346948 cites W2225996156 @default.
- W2898346948 cites W2322875593 @default.
- W2898346948 cites W2346020725 @default.
- W2898346948 cites W2461724147 @default.
- W2898346948 cites W2472961939 @default.
- W2898346948 cites W2523276611 @default.
- W2898346948 cites W2528749195 @default.
- W2898346948 cites W2738193274 @default.
- W2898346948 cites W2738408208 @default.
- W2898346948 cites W2753540656 @default.
- W2898346948 cites W2754290138 @default.
- W2898346948 cites W2755066066 @default.
- W2898346948 cites W2801944335 @default.
- W2898346948 cites W992937218 @default.
- W2898346948 doi "https://doi.org/10.1016/j.fct.2018.10.056" @default.
- W2898346948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30393115" @default.
- W2898346948 hasPublicationYear "2019" @default.
- W2898346948 type Work @default.
- W2898346948 sameAs 2898346948 @default.
- W2898346948 citedByCount "14" @default.
- W2898346948 countsByYear W28983469482019 @default.
- W2898346948 countsByYear W28983469482020 @default.
- W2898346948 countsByYear W28983469482021 @default.
- W2898346948 countsByYear W28983469482022 @default.
- W2898346948 countsByYear W28983469482023 @default.
- W2898346948 crossrefType "journal-article" @default.
- W2898346948 hasAuthorship W2898346948A5009182383 @default.
- W2898346948 hasAuthorship W2898346948A5015410771 @default.
- W2898346948 hasAuthorship W2898346948A5027255197 @default.
- W2898346948 hasAuthorship W2898346948A5035819379 @default.
- W2898346948 hasAuthorship W2898346948A5050006956 @default.
- W2898346948 hasAuthorship W2898346948A5055940705 @default.
- W2898346948 hasAuthorship W2898346948A5057276762 @default.
- W2898346948 hasAuthorship W2898346948A5061870742 @default.
- W2898346948 hasAuthorship W2898346948A5073391787 @default.
- W2898346948 hasConcept C104317684 @default.
- W2898346948 hasConcept C126322002 @default.
- W2898346948 hasConcept C134018914 @default.