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- W2898388655 abstract "Dynamic changes in astrocyte free Ca2+ regulate synaptic signaling and local blood flow. Although astrocytes are poised to integrate signals from synapses and the vasculature to perform their functional roles, it remains unclear what dictates astrocyte responses during neurovascular coupling under realistic conditions. We examined peri-arteriole and peri-capillary astrocytes in the barrel cortex of active mice in response to sensory stimulation or volitional behaviors. We observed an AMPA and NMDA receptor-dependent elevation in astrocyte endfoot Ca2+ that followed functional hyperemia onset. This delayed astrocyte Ca2+ signal was dependent on the animal's action at the time of measurement as well as a neurovascular pathway that linked to endothelial-derived nitric oxide. A similar elevation in endfoot Ca2+ was evoked using vascular chemogenetics or optogenetics, and opto-stimulated dilation recruited the same nitric oxide pathway as functional hyperemia. These data show that behavioral state and microvasculature influence astrocyte Ca2+ in active mice. VIDEO ABSTRACT." @default.
- W2898388655 created "2018-11-02" @default.
- W2898388655 creator A5050710617 @default.
- W2898388655 creator A5069626014 @default.
- W2898388655 creator A5082743000 @default.
- W2898388655 date "2018-12-01" @default.
- W2898388655 modified "2023-10-17" @default.
- W2898388655 title "Astrocytes Integrate Behavioral State and Vascular Signals during Functional Hyperemia" @default.
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- W2898388655 doi "https://doi.org/10.1016/j.neuron.2018.09.045" @default.
- W2898388655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30482689" @default.
- W2898388655 hasPublicationYear "2018" @default.
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