Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898398260> ?p ?o ?g. }
- W2898398260 endingPage "54" @default.
- W2898398260 startingPage "38" @default.
- W2898398260 abstract "Abstract Glucocorticoids (GCs) are essential for stress adaptation, acting centrally and in the periphery. Corticotropin-releasing factor (CRF), a major regulator of adrenal GC synthesis, is produced in the paraventricular nucleus of the hypothalamus (PVH), which contains multiple neuroendocrine and preautonomic neurons. GCs may be involved in diverse regulatory mechanisms in the PVH, but the target genes of GCs are largely unexplored except for the CRF gene (Crh), a well-known target for GC negative feedback. Using a genome-wide RNA-sequencing analysis, we identified transcripts that changed in response to either high-dose corticosterone (Cort) exposure for 12 days (12-day high Cort), corticoid deprivation for 7 days (7-day ADX), or acute Cort administration. Among others, canonical GC target genes were upregulated prominently by 12-day high Cort. Crh was upregulated or downregulated most prominently by either 7-day ADX or 12-day high Cort, emphasizing the recognized feedback effects of GC on the hypothalamic-pituitary-adrenal (HPA) axis. Concomitant changes in vasopressin and apelin receptor gene expression are likely to contribute to HPA repression. In keeping with the pleotropic cellular actions of GCs, 7-day ADX downregulated numerous genes of a broad functional spectrum. The transcriptome response signature differed markedly between acute Cort injection and 12-day high Cort. Remarkably, six immediate early genes were upregulated 1 hour after Cort injection, which was confirmed by quantitative reverse transcription PCR and semiquantitative in situ hybridization. This study may provide a useful database for studying the regulatory mechanisms of GC-dependent gene expression and repression in the PVH." @default.
- W2898398260 created "2018-11-02" @default.
- W2898398260 creator A5010779419 @default.
- W2898398260 creator A5010945093 @default.
- W2898398260 creator A5058687274 @default.
- W2898398260 creator A5060002817 @default.
- W2898398260 creator A5070927325 @default.
- W2898398260 creator A5073976571 @default.
- W2898398260 creator A5086898337 @default.
- W2898398260 creator A5091869411 @default.
- W2898398260 date "2018-10-25" @default.
- W2898398260 modified "2023-10-03" @default.
- W2898398260 title "Genome-Wide Analysis of Glucocorticoid-Responsive Transcripts in the Hypothalamic Paraventricular Region of Male Rats" @default.
- W2898398260 cites W1506472558 @default.
- W2898398260 cites W1594205240 @default.
- W2898398260 cites W1600361555 @default.
- W2898398260 cites W1703083962 @default.
- W2898398260 cites W1972124891 @default.
- W2898398260 cites W1972626076 @default.
- W2898398260 cites W1974088820 @default.
- W2898398260 cites W1974793156 @default.
- W2898398260 cites W1979665827 @default.
- W2898398260 cites W1986525663 @default.
- W2898398260 cites W1989992663 @default.
- W2898398260 cites W1998000745 @default.
- W2898398260 cites W1999319214 @default.
- W2898398260 cites W2001540932 @default.
- W2898398260 cites W2003063301 @default.
- W2898398260 cites W2006238285 @default.
- W2898398260 cites W2006473625 @default.
- W2898398260 cites W2016200185 @default.
- W2898398260 cites W2020163395 @default.
- W2898398260 cites W2024858865 @default.
- W2898398260 cites W2025231532 @default.
- W2898398260 cites W2027689592 @default.
- W2898398260 cites W2033293674 @default.
- W2898398260 cites W2037549475 @default.
- W2898398260 cites W2040889890 @default.
- W2898398260 cites W2046887050 @default.
- W2898398260 cites W2046960533 @default.
- W2898398260 cites W2048259050 @default.
- W2898398260 cites W2058877345 @default.
- W2898398260 cites W2059722505 @default.
- W2898398260 cites W2062548726 @default.
- W2898398260 cites W2062877364 @default.
- W2898398260 cites W2066106471 @default.
- W2898398260 cites W2066941348 @default.
- W2898398260 cites W2070611918 @default.
- W2898398260 cites W2071645208 @default.
- W2898398260 cites W2071844446 @default.
- W2898398260 cites W2083773661 @default.
- W2898398260 cites W2087522472 @default.
- W2898398260 cites W2088159839 @default.
- W2898398260 cites W2090085389 @default.
- W2898398260 cites W2094025049 @default.
- W2898398260 cites W2095611844 @default.
- W2898398260 cites W2098675143 @default.
- W2898398260 cites W2100305481 @default.
- W2898398260 cites W2111878641 @default.
- W2898398260 cites W2113112889 @default.
- W2898398260 cites W2123995229 @default.
- W2898398260 cites W2126405504 @default.
- W2898398260 cites W2129340317 @default.
- W2898398260 cites W2132539548 @default.
- W2898398260 cites W2140729960 @default.
- W2898398260 cites W2141224543 @default.
- W2898398260 cites W2143965041 @default.
- W2898398260 cites W2145691687 @default.
- W2898398260 cites W2146483390 @default.
- W2898398260 cites W2149687545 @default.
- W2898398260 cites W2149742562 @default.
- W2898398260 cites W2153825312 @default.
- W2898398260 cites W2154903350 @default.
- W2898398260 cites W2160273439 @default.
- W2898398260 cites W2163524075 @default.
- W2898398260 cites W2167716438 @default.
- W2898398260 cites W2759508077 @default.
- W2898398260 cites W2769071992 @default.
- W2898398260 cites W2770724733 @default.
- W2898398260 cites W4233170815 @default.
- W2898398260 cites W4242638888 @default.
- W2898398260 cites W4378346933 @default.
- W2898398260 doi "https://doi.org/10.1210/en.2018-00535" @default.
- W2898398260 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6302960" @default.
- W2898398260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30364965" @default.
- W2898398260 hasPublicationYear "2018" @default.
- W2898398260 type Work @default.
- W2898398260 sameAs 2898398260 @default.
- W2898398260 citedByCount "8" @default.
- W2898398260 countsByYear W28983982602019 @default.
- W2898398260 countsByYear W28983982602020 @default.
- W2898398260 countsByYear W28983982602021 @default.
- W2898398260 countsByYear W28983982602022 @default.
- W2898398260 crossrefType "journal-article" @default.
- W2898398260 hasAuthorship W2898398260A5010779419 @default.
- W2898398260 hasAuthorship W2898398260A5010945093 @default.
- W2898398260 hasAuthorship W2898398260A5058687274 @default.
- W2898398260 hasAuthorship W2898398260A5060002817 @default.