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- W2898415838 abstract "Methylsulfonic apatinib showed promising efficacy for the treatment of non–small-cell lung cancer (NSCLC) as one of the TKIs which specifically inhibits VEGFR-2. We aimed to assess the efficacy of apatinib in each lines of treatment to patients with advanced/metastatic NSCLC. We retrospectively analyzed variables and outcomes of patients with advanced NSCLC, who had received apatinib between January 1, 2016 and April 30, 2018, including: 5 patients of first line treatment, 16 second line treatment, 20 third line treatment and 6 fourth and fifth line treatment. The most frequent treatment-related adverse events were hypertension, proteinuria, hand-foot skin reaction and hemoptysis. Among the 47 cases included in the final analysis, the median progression-free survival among patients was 5.66 months specialized in: 0-24.0 months in first line treatment, 0-10.0 in second line treatment, 2.0-10.0 in third line treatment and 0.6-5.4 months in fourth and fifth line treatment. The median overall survival time for apatinib were 25.97 months, 21.4-28.5 months in third line treatment and 0-64.9 months in fourth and fifth line treatment. No significance was found in either PFS and OS among lines of treatment, histology and EGFR mutation status The results indicate the administration of apatinib could be used as an alternative for advanced/metastatic NSCLC patients." @default.
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- W2898415838 date "2018-10-01" @default.
- W2898415838 modified "2023-10-17" @default.
- W2898415838 title "P2.01-131 Apatinib as an Alternative for Advanced Non-Small Cell Lung Cancer" @default.
- W2898415838 doi "https://doi.org/10.1016/j.jtho.2018.08.1186" @default.
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