FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898428897> ?p ?o ?g. }

• W2898428897 endingPage "19194" @default.
• W2898428897 startingPage "19179" @default.
• W2898428897 abstract "Lipid-porphyrin conjugates are considered nowadays as promising building blocks for the conception of supramolecular structures with multifunctional properties, required for efficient cancer therapy by photodynamic therapy (PDT). The synthesis of two new lipid-porphyrin conjugates coupling pheophorbide-a (Pheo-a), a photosensitizer derived from chlorophyll-a, to either chemically modified lyso-phosphatidylcholine (PhLPC) or egg lyso-sphingomyelin (PhLSM) is reported. The impact of the lipid backbone of these conjugates on their self-assembling properties, as well as on their physicochemical properties, including interfacial behavior at the air/buffer interface, fluorescence and absorption properties, thermotropic behavior, and incorporation rate in the membrane of liposomes were studied. Finally, their photodynamic activity was evaluated on esophageal squamous cell carcinoma (ESCC) and normal esophageal squamous epithelium cell lines. The liposome-like vesicles resulting from self-assembly of the pure conjugates were unstable and turned into aggregates with undefined structure within few days. However, both lipid-porphyrin conjugates could be efficiently incorporated in lipid vesicles, with higher loading rates than unconjugated Pheo-a. Interestingly, phototoxicity tests of free and liposome-incorporated lipid-porphyrin conjugates demonstrated a better selectivity in vitro to esophageal squamous cell carcinoma relative to normal cells." @default.
• W2898428897 created "2018-11-02" @default.
• W2898428897 creator A5006229072 @default.
• W2898428897 creator A5022289395 @default.
• W2898428897 creator A5060333382 @default.
• W2898428897 creator A5064476476 @default.
• W2898428897 creator A5069964740 @default.
• W2898428897 creator A5069986207 @default.
• W2898428897 creator A5079450836 @default.
• W2898428897 creator A5086011327 @default.
• W2898428897 date "2018-12-11" @default.
• W2898428897 modified "2023-10-18" @default.
• W2898428897 title "Newly Synthesized Lipid–Porphyrin Conjugates: Evaluation of Their Self‐Assembling Properties, Their Miscibility with Phospholipids and Their Photodynamic Activity In Vitro" @default.
• W2898428897 cites W1086713596 @default.
• W2898428897 cites W148909682 @default.
• W2898428897 cites W1581243243 @default.
• W2898428897 cites W1964779269 @default.
• W2898428897 cites W1964962292 @default.
• W2898428897 cites W1966399926 @default.
• W2898428897 cites W1971292240 @default.
• W2898428897 cites W1974735351 @default.
• W2898428897 cites W1975299486 @default.
• W2898428897 cites W1978094989 @default.
• W2898428897 cites W1981151214 @default.
• W2898428897 cites W1982721946 @default.
• W2898428897 cites W1984417493 @default.
• W2898428897 cites W1986754429 @default.
• W2898428897 cites W1988691170 @default.
• W2898428897 cites W2016343967 @default.
• W2898428897 cites W2023460100 @default.
• W2898428897 cites W2029667189 @default.
• W2898428897 cites W2033699650 @default.
• W2898428897 cites W2053354626 @default.
• W2898428897 cites W2055875086 @default.
• W2898428897 cites W2056501637 @default.
• W2898428897 cites W2061148954 @default.
• W2898428897 cites W2065448514 @default.
• W2898428897 cites W2066790039 @default.
• W2898428897 cites W2069839886 @default.
• W2898428897 cites W2072732518 @default.
• W2898428897 cites W2073932571 @default.
• W2898428897 cites W2079973382 @default.
• W2898428897 cites W2080099587 @default.
• W2898428897 cites W2085215982 @default.
• W2898428897 cites W2086529087 @default.
• W2898428897 cites W2091239867 @default.
• W2898428897 cites W2092507495 @default.
• W2898428897 cites W2092706511 @default.
• W2898428897 cites W2093522188 @default.
• W2898428897 cites W2094773533 @default.
• W2898428897 cites W2106284499 @default.
• W2898428897 cites W2117570650 @default.
• W2898428897 cites W2120430290 @default.
• W2898428897 cites W2124733101 @default.
• W2898428897 cites W2133720275 @default.
• W2898428897 cites W2141311549 @default.
• W2898428897 cites W2142885730 @default.
• W2898428897 cites W2149216903 @default.
• W2898428897 cites W2156223772 @default.
• W2898428897 cites W2157812356 @default.
• W2898428897 cites W2160679445 @default.
• W2898428897 cites W2161869126 @default.
• W2898428897 cites W2166458266 @default.
• W2898428897 cites W2170344807 @default.
• W2898428897 cites W2231811577 @default.
• W2898428897 cites W2256387072 @default.
• W2898428897 cites W2262251211 @default.
• W2898428897 cites W2309276022 @default.
• W2898428897 cites W2320198816 @default.
• W2898428897 cites W2343061763 @default.
• W2898428897 cites W2344850880 @default.
• W2898428897 cites W2416766755 @default.
• W2898428897 cites W2429541564 @default.
• W2898428897 cites W2604396454 @default.
• W2898428897 cites W2619292616 @default.
• W2898428897 cites W2761524711 @default.
• W2898428897 cites W2762348789 @default.
• W2898428897 cites W2762642281 @default.
• W2898428897 cites W2766527333 @default.
• W2898428897 cites W2790960759 @default.
• W2898428897 cites W2791771206 @default.
• W2898428897 cites W4211024586 @default.
• W2898428897 cites W4250736207 @default.
• W2898428897 doi "https://doi.org/10.1002/chem.201804865" @default.
• W2898428897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30362192" @default.
• W2898428897 hasPublicationYear "2018" @default.
• W2898428897 type Work @default.
• W2898428897 sameAs 2898428897 @default.
• W2898428897 citedByCount "25" @default.
• W2898428897 countsByYear W28984288972019 @default.
• W2898428897 countsByYear W28984288972020 @default.
• W2898428897 countsByYear W28984288972021 @default.
• W2898428897 countsByYear W28984288972022 @default.
• W2898428897 countsByYear W28984288972023 @default.
• W2898428897 crossrefType "journal-article" @default.
• W2898428897 hasAuthorship W2898428897A5006229072 @default.
• W2898428897 hasAuthorship W2898428897A5022289395 @default.
• W2898428897 hasAuthorship W2898428897A5060333382 @default.

• next