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• W2898431131 endingPage "175" @default.
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• W2898431131 abstract "To investigate the role of Astrocyte elevated gene-1 (AEG-1) in the development and progress of pancreatic cancer, short hairpin RNA (shRNA) was inserted into the RNA interference vector to knock-down the endogenous AEG-1 in two pancreatic cancer cell lines: AsPC-1 and PANC-1. Our results showed that silencing of AEG-1 suppressed the proliferation, colony formation ability, and cell stemness of AsPC-1 and PANC-1 cells, and inhibited their G1-to-S phase transition. Results from apoptosis assay showed that knock-down of AEG-1 led to cell apoptosis. The expression of anti-apoptotic Bcl-2 was downregulated and that of the pro-apoptotic Bax and cleaved caspase-3 was upregulated in AEG-1-silenced pancreatic cancer cells. Further, the capability of AEG-1-silenced cells to migrate and to invade through the Matrigel-coated membrane was weaker, and the expression of matrix metallopeptidase 2 (MMP-2) and MMP-9 were decreased. Moreover, the AKT–β-catenin signaling pathway was inhibited in the cells with knock-down of AEG-1. In addition, the growth of xenograft tumors formed by AsPC-1 and PANC-1 cells was suppressed by AEG-1 shRNA. In conclusion, our study demonstrates that pancreatic cancer cells require AEG-1 to maintain their survival and metastasis, suggesting AEG-1 as a potential target for the treatment of pancreatic cancers." @default.
• W2898431131 created "2018-11-02" @default.
• W2898431131 creator A5040284754 @default.
• W2898431131 creator A5040487354 @default.
• W2898431131 date "2019-04-01" @default.
• W2898431131 modified "2023-09-25" @default.
• W2898431131 title "Silencing of <i>Astrocyte elevated gene-1</i> (<i>AEG-1</i>) inhibits proliferation, migration, and invasiveness, and promotes apoptosis in pancreatic cancer cells" @default.
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• W2898431131 doi "https://doi.org/10.1139/bcb-2018-0181" @default.
• W2898431131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30359541" @default.
• W2898431131 hasPublicationYear "2019" @default.
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