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- W2898439478 abstract "Goal: We evaluated the potential for prenatal diagnosis of merosin-negative muscular dystrophies by immunohistochemistry. Materials and Methods: This is a retrospective study of 12 pregnancies with merosin-negative muscular dystrophy in a prior child. Chorionic villus sampling (CVS) was performed between 11th to 13th gestational weeks. Merosin immunohistochemical studies were performed on trophoblastic cells. Results: Two of 12 were “merosin-negative,” both were from the same family. Fetal ultrasonographies were evaluated as normal in these pregnancies. Eight of the 10 merosin-positive cases delivered healthy babies. Two were lost to follow-up. Conclusion: Prenatal diagnosis of merosin-negative muscular dystrophies can be accomplished by immunohistochemical analysis." @default.
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- W2898439478 date "2018-10-25" @default.
- W2898439478 modified "2023-10-18" @default.
- W2898439478 title "Prenatal Diagnosis of Merosin-Deficient Muscular Dystrophy" @default.
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- W2898439478 doi "https://doi.org/10.1080/15513815.2018.1520944" @default.
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