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- W2898450901 abstract "本研究采用亲水作用色谱柱串联四极杆-静电场轨道阱-线性离子阱三合一组合式高分辨质谱仪（HILIC/Orbitrap Fusion Lumos HRMS）建立了快速智能化鉴定瓜蒌皮注射液中化学成分的分析方法。采用Compound Discoverer软件，检索在线数据库ChemSpider和mzCloud，共鉴定了48个化学成分，包括生物碱、氨基酸、核苷及其碱基等，其中25个通过与对照品对照进行了准确鉴定，基本阐明了瓜蒌皮注射液的化学物质基础。采用该方法采集21批样品数据，以48个成分的峰面积为观察值，进行主成分分析，考察不同批次样品间的稳定性，结果显示注射液批间差异性的主要来源为原料药材，注射液制备工艺相对稳定。本研究为瓜蒌皮注射液的药效物质基础研究及质量标准提高研究提供了重要参考。" @default.
- W2898450901 created "2018-11-02" @default.
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- W2898450901 date "2018-04-04" @default.
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- W2898450901 title "HILIC/ESI-Orbitrap HRMS法结合Compound Discoverer软件快速智能化鉴定瓜蒌皮注射液中的化学成分" @default.
- W2898450901 doi "https://doi.org/10.16438/j.0513-4870.2018-0302" @default.
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