FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898454985> ?p ?o ?g. }

• W2898454985 abstract "Spinal cord injury (SCI) followed by extensive cell loss, inflammation, and scarring, often permanently damages neurological function. Biomaterial scaffolds are promising but currently have limited applicability in SCI because after entering the scaffold, regenerating axons tend to become trapped and rarelyre-enter the host tissue, the reasons for which remain to be completely explored. Here, we propose a mathematical model and computer simulation for characterizing regenerative axons growing along a scaffold following SCI, and how their growth may be guided. The model assumed a solid, spherical, multifunctional, biomaterial scaffold, that would bridge the rostral and caudal stumps of a completely transected spinal cord in a rat model and would guide the rostral regenerative axons toward the caudal tissue. Other assumptions include the whole scaffold being coated with extracellular matrix components, and the caudal area being additionally seeded with chemoattractants. The chemical factors on and around the scaffold were formulated to several coupled variables, and the parameter values were derived fromexisting experimental data. Special attention was given to the effects of coating strength, seeding location, and seeding density, as well as the ramp slope of the scaffold, on axonal regeneration. In numerical simulations, a slimmer scaffold provided a small slope at the entry on-ramp area that improved the success rate of axonal regeneration. If success rates are high, an increased number of regenerative axons traverse through the narrow channels, causing congestion and lowering the growth rate. An increase in the number of severed axons (300-12000) did not significantly affect the growth rate, but it reduced the success rate of axonal regeneration. However, an increase in the seeding densities of the complexes on the whole scaffold, and that in the seeding densities of the chemoattractants on the caudal area, improved both the success and growth rates. However, an increase in the density of thecomplexes on the whole scaffold risks an over-eutrophic surface that harms axonal regeneration.Although theoretical predictions are yet to be validated directly by experiments, this theoretical tool can advance the treatment of SCI, and is also applicable to scaffolds with other architectures." @default.
• W2898454985 created "2018-11-02" @default.
• W2898454985 creator A5050852420 @default.
• W2898454985 creator A5073706481 @default.
• W2898454985 creator A5082326016 @default.
• W2898454985 creator A5082879157 @default.
• W2898454985 creator A5088063289 @default.
• W2898454985 date "2018-10-26" @default.
• W2898454985 modified "2023-09-30" @default.
• W2898454985 title "Numerical characterization of regenerative axons growing along a spherical multifunctional scaffold after spinal cord injury" @default.
• W2898454985 cites W137291024 @default.
• W2898454985 cites W140154881 @default.
• W2898454985 cites W1506438655 @default.
• W2898454985 cites W1563372168 @default.
• W2898454985 cites W1952053031 @default.
• W2898454985 cites W1966901068 @default.
• W2898454985 cites W1974747930 @default.
• W2898454985 cites W1983343963 @default.
• W2898454985 cites W1984362646 @default.
• W2898454985 cites W1985980289 @default.
• W2898454985 cites W2001027721 @default.
• W2898454985 cites W2005416260 @default.
• W2898454985 cites W2008834137 @default.
• W2898454985 cites W2010234007 @default.
• W2898454985 cites W2011892172 @default.
• W2898454985 cites W2012468912 @default.
• W2898454985 cites W2015832877 @default.
• W2898454985 cites W2016616421 @default.
• W2898454985 cites W2017476860 @default.
• W2898454985 cites W2017856054 @default.
• W2898454985 cites W2027464335 @default.
• W2898454985 cites W2029768920 @default.
• W2898454985 cites W2033712349 @default.
• W2898454985 cites W2035529971 @default.
• W2898454985 cites W2039422279 @default.
• W2898454985 cites W2040377251 @default.
• W2898454985 cites W2043543037 @default.
• W2898454985 cites W2055205487 @default.
• W2898454985 cites W2059597336 @default.
• W2898454985 cites W2064349842 @default.
• W2898454985 cites W2066445702 @default.
• W2898454985 cites W2076511886 @default.
• W2898454985 cites W2078928598 @default.
• W2898454985 cites W2079329053 @default.
• W2898454985 cites W2080186285 @default.
• W2898454985 cites W2081982208 @default.
• W2898454985 cites W2082824466 @default.
• W2898454985 cites W2085788811 @default.
• W2898454985 cites W2088365093 @default.
• W2898454985 cites W2091236027 @default.
• W2898454985 cites W2102949617 @default.
• W2898454985 cites W2103705551 @default.
• W2898454985 cites W2104231587 @default.
• W2898454985 cites W2104968232 @default.
• W2898454985 cites W2117242079 @default.
• W2898454985 cites W2124248841 @default.
• W2898454985 cites W2127447774 @default.
• W2898454985 cites W2144797754 @default.
• W2898454985 cites W2157727435 @default.
• W2898454985 cites W2168250283 @default.
• W2898454985 cites W2288271511 @default.
• W2898454985 cites W2347141193 @default.
• W2898454985 cites W2614111790 @default.
• W2898454985 cites W2738592067 @default.
• W2898454985 doi "https://doi.org/10.1371/journal.pone.0205961" @default.
• W2898454985 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6203361" @default.
• W2898454985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30365562" @default.
• W2898454985 hasPublicationYear "2018" @default.
• W2898454985 type Work @default.
• W2898454985 sameAs 2898454985 @default.
• W2898454985 citedByCount "0" @default.
• W2898454985 crossrefType "journal-article" @default.
• W2898454985 hasAuthorship W2898454985A5050852420 @default.
• W2898454985 hasAuthorship W2898454985A5073706481 @default.
• W2898454985 hasAuthorship W2898454985A5082326016 @default.
• W2898454985 hasAuthorship W2898454985A5082879157 @default.
• W2898454985 hasAuthorship W2898454985A5088063289 @default.
• W2898454985 hasBestOaLocation W28984549851 @default.
• W2898454985 hasConcept C105702510 @default.
• W2898454985 hasConcept C10854531 @default.
• W2898454985 hasConcept C136229726 @default.
• W2898454985 hasConcept C169760540 @default.
• W2898454985 hasConcept C171056886 @default.
• W2898454985 hasConcept C192562407 @default.
• W2898454985 hasConcept C2778334475 @default.
• W2898454985 hasConcept C2778414984 @default.
• W2898454985 hasConcept C2779530196 @default.
• W2898454985 hasConcept C2780775167 @default.
• W2898454985 hasConcept C28328180 @default.
• W2898454985 hasConcept C49892992 @default.
• W2898454985 hasConcept C71924100 @default.
• W2898454985 hasConcept C86803240 @default.
• W2898454985 hasConcept C89429830 @default.
• W2898454985 hasConcept C95444343 @default.
• W2898454985 hasConceptScore W2898454985C105702510 @default.
• W2898454985 hasConceptScore W2898454985C10854531 @default.
• W2898454985 hasConceptScore W2898454985C136229726 @default.
• W2898454985 hasConceptScore W2898454985C169760540 @default.
• W2898454985 hasConceptScore W2898454985C171056886 @default.
• W2898454985 hasConceptScore W2898454985C192562407 @default.

• next