FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898456415> ?p ?o ?g. }

• W2898456415 endingPage "420" @default.
• W2898456415 startingPage "420" @default.
• W2898456415 abstract "Regulation of cholesterol (Chol) homeostasis is controlled by three main fluxes, i.e. intestinal absorption, de novo synthesis (ChS) and catabolism, predominantly as bile acid synthesis (BAS). High serum total Chol and LDL-Chol concentrations in particular are considered risk factors and markers for the development of atherosclerosis. Pharmaceutical treatments to lower serum Chol have focused on reducing absorption or ChS and increasing BAS. Monitoring of these three parameters is complex involving isotope techniques, cholesterol balance experiments and advanced mass spectrometry based analysis methods. Surrogate markers were explored that require only one single fasting blood sample collection. These markers were validated in specific, mostly physiological conditions and during statin treatment to inhibit ChS. They were also applied under cholesterol absorption restriction, but were not validated in this condition. We retrospectively evaluated the use of serum campesterol (Camp), sitosterol (Sit) and cholestanol (Cholol) as markers for cholesterol absorption, lathosterol (Lath) as marker for ChS and 7α-hydroxycholesterol (7α-OH-Ch) and 27-hydroxycholesterol (27-OH-Ch) as markers for BAS under conditions of Chol absorption restriction. Additionally, their values were corrected for Chol concentration (R_sterol or oxysterols).Thirty-seven healthy male omnivore subjects were studied under treatments with placebo (PLAC), ezetimibe (EZE) to inhibit cholesterol absorption, simvastatin (SIMVA) to reduce cholesterol synthesis and a combination of both (EZE + SIMVA). Results were compared to those obtained in 18 pure vegetarian subjects (vegans) whose dietary Chol intake is extremely low. Relative or fractional Chol absorption (FrChA) was measured with the continuous feeding stable isotope procedure, ChS and BAS with the cholesterol balance method. The daily Chol intake (DICh) was inventoried and the daily Chol absorption (DACh) calculated.Monitoring cholesterol absorption, R_Camp, R_Sit and R_Cholol responded sensitively to changes in FrChA. R_Camp correlated well with FrChA in all omnivore treatment groups and in the vegan group. R_Camp confirmed reduced FrChA under EZE treatment and reduced DACh in the vegan subjects. R_Sit and R_Cholol did not accurately reflect FrChA or DACh in all situations. Monitoring endogenous cholesterol synthesis, R_Lath correlated with ChS in the vegan group, but in none of the omnivore treatment groups. R_Lath confirmed increased ChS under EZE treatment and was reduced under SIMVA treatment, while ChS was not. An increased ChS under EZE + SIMVA treatment could not be confirmed with R_Lath. R_Lath responded very insensitively to a change in ChS. Monitoring BAS, R_7α-OH-Ch but not R_27-OH-Ch correlated with BAS during PLAC, EZE and SIMVA treatments. In line with BAS, R_7α-OH-Ch did not differ in any of the omnivore treatment groups. R_7α-OH-Ch responded insensitively to a change in BAS.Under Chol absorption restriction, serum R_Camp is a sensitive and valid marker to monitor FrChA in a population with a normal DICh. Also, major changes in DACh can be detected in vegans. Serum R_Lath does not reflect ChS measured with the cholesterol balance method during EZE treatment. This result initiates the question whether the measured ChS reflects pure de novo synthesis. Serum R_7α-OH-Ch appears to be a valid but insensitive marker for BAS." @default.
• W2898456415 created "2018-11-02" @default.
• W2898456415 creator A5043935811 @default.
• W2898456415 date "2018-12-01" @default.
• W2898456415 modified "2023-09-26" @default.
• W2898456415 title "PO179 Novel Cardiac Protective Agent, AFC1, Attenuated Ischemic Reperfusion Induced Ventricular Remodeling via Inhibiting PDGFR and JAK/STAT Pathways" @default.
• W2898456415 doi "https://doi.org/10.1016/j.gheart.2018.09.157" @default.
• W2898456415 hasPublicationYear "2018" @default.
• W2898456415 type Work @default.
• W2898456415 sameAs 2898456415 @default.
• W2898456415 citedByCount "0" @default.
• W2898456415 crossrefType "journal-article" @default.
• W2898456415 hasAuthorship W2898456415A5043935811 @default.
• W2898456415 hasConcept C126322002 @default.
• W2898456415 hasConcept C134018914 @default.
• W2898456415 hasConcept C2776329913 @default.
• W2898456415 hasConcept C2776839432 @default.
• W2898456415 hasConcept C2778163477 @default.
• W2898456415 hasConcept C2778657065 @default.
• W2898456415 hasConcept C2778718757 @default.
• W2898456415 hasConcept C2780022283 @default.
• W2898456415 hasConcept C2781471481 @default.
• W2898456415 hasConcept C71924100 @default.
• W2898456415 hasConcept C98274493 @default.
• W2898456415 hasConceptScore W2898456415C126322002 @default.
• W2898456415 hasConceptScore W2898456415C134018914 @default.
• W2898456415 hasConceptScore W2898456415C2776329913 @default.
• W2898456415 hasConceptScore W2898456415C2776839432 @default.
• W2898456415 hasConceptScore W2898456415C2778163477 @default.
• W2898456415 hasConceptScore W2898456415C2778657065 @default.
• W2898456415 hasConceptScore W2898456415C2778718757 @default.
• W2898456415 hasConceptScore W2898456415C2780022283 @default.
• W2898456415 hasConceptScore W2898456415C2781471481 @default.
• W2898456415 hasConceptScore W2898456415C71924100 @default.
• W2898456415 hasConceptScore W2898456415C98274493 @default.
• W2898456415 hasIssue "4" @default.
• W2898456415 hasLocation W28984564151 @default.
• W2898456415 hasOpenAccess W2898456415 @default.
• W2898456415 hasPrimaryLocation W28984564151 @default.
• W2898456415 hasRelatedWork W1989492995 @default.
• W2898456415 hasRelatedWork W2013864378 @default.
• W2898456415 hasRelatedWork W2020687765 @default.
• W2898456415 hasRelatedWork W2053087833 @default.
• W2898456415 hasRelatedWork W2054560937 @default.
• W2898456415 hasRelatedWork W2080241928 @default.
• W2898456415 hasRelatedWork W2129650002 @default.
• W2898456415 hasRelatedWork W2135589992 @default.
• W2898456415 hasRelatedWork W2215203156 @default.
• W2898456415 hasRelatedWork W2589251695 @default.
• W2898456415 hasVolume "13" @default.
• W2898456415 isParatext "false" @default.
• W2898456415 isRetracted "false" @default.
• W2898456415 magId "2898456415" @default.
• W2898456415 workType "article" @default.