FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898456465> ?p ?o ?g. }

• W2898456465 endingPage "55" @default.
• W2898456465 startingPage "45" @default.
• W2898456465 abstract "Tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb), remains a serious global health problem. The PE/PPE family, featuring unique sequences, structures and expression in Mtb, is reported to interfere with the macrophage response to the pathogen and facilitate its infection. PPE11 (Rv0453) existed in pathogenic mycobacteria and was persistently expressed in the infected guinea pig lungs. However, the role it played in the pathogenesis remains unclear. Here, to investigate the interaction and potential mechanism of PPE11 between pathogens and hosts, we heterologously expressed PPE11 in non-pathogenic, rapidly growing Mycobacterium smegmatis strains. We found that the overexpression of the cell wall-associated protein, PPE11, can improve the viability of bacteria in the presence of lysozyme, hydrogen peroxide and acid stress. Expression of PPE11 enhanced the early survival of M. smegmatis in macrophages and sustained a higher bacterial load in mouse tissues that showed exacerbated organ pathology. Macrophages infected with recombinant M. smegmatis produced significantly greater amounts of interleukin (IL)-1β, IL-6, tumour necrosis factor (TNF)-α and an early decrease in IL-10 along with higher levels of host cell death. Similar cytokines changes were observed in the sera of infected mice. Accordingly, PPE11 protein causes histopathological changes by disrupting the dynamic balance of the inflammatory factors and promoting host-cell death, indicating a potential role in the virulence of Mtb." @default.
• W2898456465 created "2018-11-02" @default.
• W2898456465 creator A5007816064 @default.
• W2898456465 creator A5021078253 @default.
• W2898456465 creator A5028682212 @default.
• W2898456465 creator A5038283594 @default.
• W2898456465 creator A5049823434 @default.
• W2898456465 creator A5060502188 @default.
• W2898456465 creator A5063210126 @default.
• W2898456465 creator A5073699504 @default.
• W2898456465 date "2019-01-01" @default.
• W2898456465 modified "2023-10-14" @default.
• W2898456465 title "PPE11 of Mycobacterium tuberculosis can alter host inflammatory response and trigger cell death" @default.
• W2898456465 cites W1551684330 @default.
• W2898456465 cites W1562235476 @default.
• W2898456465 cites W1906780201 @default.
• W2898456465 cites W1921088252 @default.
• W2898456465 cites W1967941125 @default.
• W2898456465 cites W1974424967 @default.
• W2898456465 cites W1977868250 @default.
• W2898456465 cites W1979076223 @default.
• W2898456465 cites W1991636630 @default.
• W2898456465 cites W1996873880 @default.
• W2898456465 cites W2006128966 @default.
• W2898456465 cites W2006433225 @default.
• W2898456465 cites W2007752039 @default.
• W2898456465 cites W2035136072 @default.
• W2898456465 cites W2040458073 @default.
• W2898456465 cites W2048884877 @default.
• W2898456465 cites W2050762131 @default.
• W2898456465 cites W2057194603 @default.
• W2898456465 cites W2064943876 @default.
• W2898456465 cites W2071876961 @default.
• W2898456465 cites W2072602445 @default.
• W2898456465 cites W2082321789 @default.
• W2898456465 cites W2090918726 @default.
• W2898456465 cites W2091468073 @default.
• W2898456465 cites W2094461142 @default.
• W2898456465 cites W2095357096 @default.
• W2898456465 cites W2106107192 @default.
• W2898456465 cites W2108210947 @default.
• W2898456465 cites W2111945182 @default.
• W2898456465 cites W2116576921 @default.
• W2898456465 cites W2128158122 @default.
• W2898456465 cites W2128564504 @default.
• W2898456465 cites W2135524542 @default.
• W2898456465 cites W2137614072 @default.
• W2898456465 cites W2140354550 @default.
• W2898456465 cites W2144010669 @default.
• W2898456465 cites W2158023121 @default.
• W2898456465 cites W2160368540 @default.
• W2898456465 cites W2163188970 @default.
• W2898456465 cites W2168062702 @default.
• W2898456465 cites W2172919339 @default.
• W2898456465 cites W2197530892 @default.
• W2898456465 cites W2298051754 @default.
• W2898456465 cites W2418131970 @default.
• W2898456465 cites W2468126483 @default.
• W2898456465 cites W2540805794 @default.
• W2898456465 cites W2564968569 @default.
• W2898456465 cites W2570877074 @default.
• W2898456465 cites W2576516298 @default.
• W2898456465 cites W2609380138 @default.
• W2898456465 cites W4253324555 @default.
• W2898456465 doi "https://doi.org/10.1016/j.micpath.2018.10.031" @default.
• W2898456465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30366125" @default.
• W2898456465 hasPublicationYear "2019" @default.
• W2898456465 type Work @default.
• W2898456465 sameAs 2898456465 @default.
• W2898456465 citedByCount "17" @default.
• W2898456465 countsByYear W28984564652019 @default.
• W2898456465 countsByYear W28984564652020 @default.
• W2898456465 countsByYear W28984564652021 @default.
• W2898456465 countsByYear W28984564652022 @default.
• W2898456465 countsByYear W28984564652023 @default.
• W2898456465 crossrefType "journal-article" @default.
• W2898456465 hasAuthorship W2898456465A5007816064 @default.
• W2898456465 hasAuthorship W2898456465A5021078253 @default.
• W2898456465 hasAuthorship W2898456465A5028682212 @default.
• W2898456465 hasAuthorship W2898456465A5038283594 @default.
• W2898456465 hasAuthorship W2898456465A5049823434 @default.
• W2898456465 hasAuthorship W2898456465A5060502188 @default.
• W2898456465 hasAuthorship W2898456465A5063210126 @default.
• W2898456465 hasAuthorship W2898456465A5073699504 @default.
• W2898456465 hasConcept C104317684 @default.
• W2898456465 hasConcept C142724271 @default.
• W2898456465 hasConcept C17991360 @default.
• W2898456465 hasConcept C190283241 @default.
• W2898456465 hasConcept C202751555 @default.
• W2898456465 hasConcept C203014093 @default.
• W2898456465 hasConcept C2776460866 @default.
• W2898456465 hasConcept C2777204207 @default.
• W2898456465 hasConcept C2777975735 @default.
• W2898456465 hasConcept C2779244956 @default.
• W2898456465 hasConcept C2780374374 @default.
• W2898456465 hasConcept C2780942790 @default.
• W2898456465 hasConcept C2781069245 @default.
• W2898456465 hasConcept C31573885 @default.

• next