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- W2898483905 abstract "A laminar-flow tubular crystallizer was used for seedless continuous flow crystallization of an active pharmaceutical ingredient, namely, Brivaracetam, which has a polymorphic behavior: rod-shaped crystals and a pseudo-polymorphic solvated, needle-like crystal. The combination of fast cooling at 20 °C/s and high supersaturation values between 4 and 11 resulted in the discrimination of nucleation and growth of only the desired crystalline form even though its solubility curve is very close to the one of the undesired needle shape. Crystal nucleation and the start of crystal growth occur inside the tubular crystallizer; high flow rates prevent clogging of the crystallizer. Further crystal growth may be, if desired, stopped via immediate filtration. In this way, an industrially applicable continuous crystallizer is proposed. It is also demonstrated that the presence of restrictions in the tubing drastically increases the nucleation rate. A literature survey points out that induced turbulence can occur under current flow conditions using said restrictions." @default.
- W2898483905 created "2018-11-02" @default.
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- W2898483905 date "2018-10-25" @default.
- W2898483905 modified "2023-10-01" @default.
- W2898483905 title "Continuous-Flow Tubular Crystallization To Discriminate between Two Competing Crystal Polymorphs. 1. Cooling Crystallization" @default.
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- W2898483905 doi "https://doi.org/10.1021/acs.cgd.8b00928" @default.
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