FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898490988> ?p ?o ?g. }

• W2898490988 endingPage "S692" @default.
• W2898490988 startingPage "S692" @default.
• W2898490988 abstract "The treatment strategy for clinical N2 (cN2) non-small cell lung cancer (NSCLC) is still controversial, because its clinical outcome is unsatisfactory and cN2 NSCLC harbors various conditions. In this study, we investigated the clinical outcome of induction chemoradiotherapy (iCRT) followed by surgery in the patients with cN2 NSCLC. During 1999 to 2016, 92 patients with cN2 NSCLC were surgically treated after iCRT in our hospital. Overall survival (OS) and relapse-free survival (RFS) were evaluated by the Kaplan-Meier method with log-rank test (univariate analyses) and by the cox proportional hazard model (multivariate analyses). Median follow-up was 49.3 months (range 3.0 - 216). Median age was 62 (21 - 79). Sixty-nine patients (75%) were male. Fifty-four and 38 patients were cStageIIIA and IIIB, respectively. Forty-six (50%) patients were adenocarcinoma. As for iCRT, the CDDP plus DTX regimen was applied for most of patients (96.7%), and the median radiation dose was 46Gy (36 - 60). Complete/major/minor pathological responses were exhibited in 29/36/27 patients, respectively. pCR was observed in 22 patients. The 5-year rates of OS and RFS were 64.1% and 48.1%, respectively. The patients with lower-lobe origin, cStage IIIA (UICC8th), poor radiological response (progressive or stable disease), minor pathological response, re-operation within 30days after surgery, or recurrence showed significantly worse OS than the others. In addition, the patients with lower lobe origin, cStageIIIA, multi-station N2, poor radiological response, or minor pathological response showed significantly worse RFS. The multivariate analysis revealed that the patients with lower-lobe origin tumors and multi-station N2 showed significantly worse OS [Hazard Ratio (HR) 2.55, 95% confidence interval (CI) 1.11 - 5.71, P= 0.028] and RFS (HR 2.45, 95%CI 1.34 - 4.69, P= 0.003), respectively. Adenocarcinoma, lower-lobe origin, multi-station N2, cStageIIIA, poor radiological response, and minor pathological response significantly correlated to recurrence. Among them, adenocarcinoma (odds ratio (OR) 3.27, 95%CI 1.21 – 8.89, P= 0.02), lower-lobe origin (OR 5.22, 95%CI 1.48 – 18.40, P= 0.01), and multi-station N2 (OR 3.63, 95%CI 1.32 – 9.88, P= 0.012) independently correlated to recurrence. iCRT followed by surgery may be one of the feasible treatment options for the patients with cN2-NSCLCs, especially for those which harbor non-lower lobe origin and multi-station N2 ." @default.
• W2898490988 created "2018-11-02" @default.
• W2898490988 creator A5000982164 @default.
• W2898490988 creator A5003352142 @default.
• W2898490988 creator A5008468584 @default.
• W2898490988 creator A5009944548 @default.
• W2898490988 creator A5019215192 @default.
• W2898490988 creator A5021333939 @default.
• W2898490988 creator A5034292501 @default.
• W2898490988 creator A5041061791 @default.
• W2898490988 creator A5062982378 @default.
• W2898490988 creator A5066700160 @default.
• W2898490988 creator A5081963190 @default.
• W2898490988 creator A5084017688 @default.
• W2898490988 creator A5091845509 @default.
• W2898490988 date "2018-10-01" @default.
• W2898490988 modified "2023-09-30" @default.
• W2898490988 title "P2.01-71 Clinical Outcome of Induction Chemoradiotherapy Followed by Surgery for the Patients with cN2 Non-Small Cell Lung Cancer" @default.
• W2898490988 doi "https://doi.org/10.1016/j.jtho.2018.08.1125" @default.
• W2898490988 hasPublicationYear "2018" @default.
• W2898490988 type Work @default.
• W2898490988 sameAs 2898490988 @default.
• W2898490988 citedByCount "0" @default.
• W2898490988 crossrefType "journal-article" @default.
• W2898490988 hasAuthorship W2898490988A5000982164 @default.
• W2898490988 hasAuthorship W2898490988A5003352142 @default.
• W2898490988 hasAuthorship W2898490988A5008468584 @default.
• W2898490988 hasAuthorship W2898490988A5009944548 @default.
• W2898490988 hasAuthorship W2898490988A5019215192 @default.
• W2898490988 hasAuthorship W2898490988A5021333939 @default.
• W2898490988 hasAuthorship W2898490988A5034292501 @default.
• W2898490988 hasAuthorship W2898490988A5041061791 @default.
• W2898490988 hasAuthorship W2898490988A5062982378 @default.
• W2898490988 hasAuthorship W2898490988A5066700160 @default.
• W2898490988 hasAuthorship W2898490988A5081963190 @default.
• W2898490988 hasAuthorship W2898490988A5084017688 @default.
• W2898490988 hasAuthorship W2898490988A5091845509 @default.
• W2898490988 hasBestOaLocation W28984909881 @default.
• W2898490988 hasConcept C121608353 @default.
• W2898490988 hasConcept C126322002 @default.
• W2898490988 hasConcept C141071460 @default.
• W2898490988 hasConcept C144301174 @default.
• W2898490988 hasConcept C190892606 @default.
• W2898490988 hasConcept C207103383 @default.
• W2898490988 hasConcept C207886595 @default.
• W2898490988 hasConcept C2776256026 @default.
• W2898490988 hasConcept C2778424827 @default.
• W2898490988 hasConcept C2781182431 @default.
• W2898490988 hasConcept C2781413609 @default.
• W2898490988 hasConcept C38180746 @default.
• W2898490988 hasConcept C44249647 @default.
• W2898490988 hasConcept C50382708 @default.
• W2898490988 hasConcept C509974204 @default.
• W2898490988 hasConcept C71924100 @default.
• W2898490988 hasConcept C90924648 @default.
• W2898490988 hasConceptScore W2898490988C121608353 @default.
• W2898490988 hasConceptScore W2898490988C126322002 @default.
• W2898490988 hasConceptScore W2898490988C141071460 @default.
• W2898490988 hasConceptScore W2898490988C144301174 @default.
• W2898490988 hasConceptScore W2898490988C190892606 @default.
• W2898490988 hasConceptScore W2898490988C207103383 @default.
• W2898490988 hasConceptScore W2898490988C207886595 @default.
• W2898490988 hasConceptScore W2898490988C2776256026 @default.
• W2898490988 hasConceptScore W2898490988C2778424827 @default.
• W2898490988 hasConceptScore W2898490988C2781182431 @default.
• W2898490988 hasConceptScore W2898490988C2781413609 @default.
• W2898490988 hasConceptScore W2898490988C38180746 @default.
• W2898490988 hasConceptScore W2898490988C44249647 @default.
• W2898490988 hasConceptScore W2898490988C50382708 @default.
• W2898490988 hasConceptScore W2898490988C509974204 @default.
• W2898490988 hasConceptScore W2898490988C71924100 @default.
• W2898490988 hasConceptScore W2898490988C90924648 @default.
• W2898490988 hasIssue "10" @default.
• W2898490988 hasLocation W28984909881 @default.
• W2898490988 hasOpenAccess W2898490988 @default.
• W2898490988 hasPrimaryLocation W28984909881 @default.
• W2898490988 hasRelatedWork W1812927431 @default.
• W2898490988 hasRelatedWork W2339607692 @default.
• W2898490988 hasRelatedWork W2356979355 @default.
• W2898490988 hasRelatedWork W2357428483 @default.
• W2898490988 hasRelatedWork W2374376758 @default.
• W2898490988 hasRelatedWork W2375813207 @default.
• W2898490988 hasRelatedWork W2379981665 @default.
• W2898490988 hasRelatedWork W2389549616 @default.
• W2898490988 hasRelatedWork W2751913398 @default.
• W2898490988 hasRelatedWork W3030061193 @default.
• W2898490988 hasVolume "13" @default.
• W2898490988 isParatext "false" @default.
• W2898490988 isRetracted "false" @default.
• W2898490988 magId "2898490988" @default.
• W2898490988 workType "article" @default.