Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898491320> ?p ?o ?g. }
- W2898491320 endingPage "354" @default.
- W2898491320 startingPage "345" @default.
- W2898491320 abstract "The crucial role of DNA polymerase eta in protecting against sunlight-induced tumors is evidenced in Xeroderma Pigmentosum Variant (XP-V) patients, who carry mutations in this protein and present increased frequency of skin cancer. XP-V cellular phenotypes may be aggravated if proteins of DNA damage response (DDR) pathway are blocked, as widely demonstrated by experiments with UVC light and caffeine. However, little is known about the participation of DDR in XP-V cells exposed to UVA light, the wavelengths patients are mostly exposed. Here, we demonstrate the participation of ATR kinase in protecting XP-V cells after receiving low UVA doses using a specific inhibitor, with a remarkable increase in sensitivity and γH2AX signaling. Corroborating ATR participation in UVA-DDR, a significant increase in Chk1 protein phosphorylation, as well as S-phase cell cycle arrest, is also observed. Moreover, the participation of oxidative stress is supported by the antioxidant action of N-acetylcysteine (NAC), which significantly protects XP-V cells from UVA light, even in the presence of the ATR inhibitor. These findings indicate that the ATR/Chk1 pathway is activated to control UVA-induced oxidatively generated DNA damage and emphasizes the role of ATR kinase as a mediator of genomic stability in pol eta defective cells." @default.
- W2898491320 created "2018-11-02" @default.
- W2898491320 creator A5002321293 @default.
- W2898491320 creator A5024146693 @default.
- W2898491320 creator A5026047874 @default.
- W2898491320 creator A5073538751 @default.
- W2898491320 creator A5079483159 @default.
- W2898491320 date "2018-11-23" @default.
- W2898491320 modified "2023-10-14" @default.
- W2898491320 title "ATR/Chk1 Pathway is Activated by Oxidative Stress in Response to UVA Light in Human Xeroderma Pigmentosum Variant Cells" @default.
- W2898491320 cites W1520446265 @default.
- W2898491320 cites W1531823089 @default.
- W2898491320 cites W1571852801 @default.
- W2898491320 cites W1588854051 @default.
- W2898491320 cites W1594035260 @default.
- W2898491320 cites W1752089945 @default.
- W2898491320 cites W1964388553 @default.
- W2898491320 cites W1965239527 @default.
- W2898491320 cites W1967630574 @default.
- W2898491320 cites W1972484974 @default.
- W2898491320 cites W1973116904 @default.
- W2898491320 cites W1976127826 @default.
- W2898491320 cites W1976538128 @default.
- W2898491320 cites W1978593193 @default.
- W2898491320 cites W1979015046 @default.
- W2898491320 cites W1980745500 @default.
- W2898491320 cites W1987397407 @default.
- W2898491320 cites W1988760590 @default.
- W2898491320 cites W1989210919 @default.
- W2898491320 cites W1995317658 @default.
- W2898491320 cites W1997847458 @default.
- W2898491320 cites W2001737065 @default.
- W2898491320 cites W2003496612 @default.
- W2898491320 cites W2006803834 @default.
- W2898491320 cites W2007830063 @default.
- W2898491320 cites W2007935491 @default.
- W2898491320 cites W2008185037 @default.
- W2898491320 cites W2009041655 @default.
- W2898491320 cites W2014999904 @default.
- W2898491320 cites W2021318316 @default.
- W2898491320 cites W2039186578 @default.
- W2898491320 cites W2044428414 @default.
- W2898491320 cites W2045775784 @default.
- W2898491320 cites W2048639395 @default.
- W2898491320 cites W2050104597 @default.
- W2898491320 cites W2053663163 @default.
- W2898491320 cites W2056298514 @default.
- W2898491320 cites W2059971436 @default.
- W2898491320 cites W2060740358 @default.
- W2898491320 cites W2062544482 @default.
- W2898491320 cites W2062564859 @default.
- W2898491320 cites W2066240511 @default.
- W2898491320 cites W2066589243 @default.
- W2898491320 cites W2069599636 @default.
- W2898491320 cites W2081809221 @default.
- W2898491320 cites W2082861064 @default.
- W2898491320 cites W2084223554 @default.
- W2898491320 cites W2087406053 @default.
- W2898491320 cites W2087702780 @default.
- W2898491320 cites W2093400775 @default.
- W2898491320 cites W2093814864 @default.
- W2898491320 cites W2093971029 @default.
- W2898491320 cites W2098619483 @default.
- W2898491320 cites W2104123741 @default.
- W2898491320 cites W2106812347 @default.
- W2898491320 cites W2106954306 @default.
- W2898491320 cites W2107418455 @default.
- W2898491320 cites W2112970145 @default.
- W2898491320 cites W2116468279 @default.
- W2898491320 cites W2119637022 @default.
- W2898491320 cites W2128223919 @default.
- W2898491320 cites W2139380885 @default.
- W2898491320 cites W2150058269 @default.
- W2898491320 cites W2151180466 @default.
- W2898491320 cites W2153466677 @default.
- W2898491320 cites W2156419287 @default.
- W2898491320 cites W2156915836 @default.
- W2898491320 cites W2158606857 @default.
- W2898491320 cites W2158941848 @default.
- W2898491320 cites W2167668429 @default.
- W2898491320 cites W2170071549 @default.
- W2898491320 cites W2231960554 @default.
- W2898491320 cites W2326730789 @default.
- W2898491320 cites W2346001051 @default.
- W2898491320 cites W2400463922 @default.
- W2898491320 cites W2521539314 @default.
- W2898491320 cites W2574794987 @default.
- W2898491320 cites W2595725535 @default.
- W2898491320 cites W3118381401 @default.
- W2898491320 doi "https://doi.org/10.1111/php.13041" @default.
- W2898491320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30362123" @default.
- W2898491320 hasPublicationYear "2018" @default.
- W2898491320 type Work @default.
- W2898491320 sameAs 2898491320 @default.
- W2898491320 citedByCount "5" @default.
- W2898491320 countsByYear W28984913202019 @default.
- W2898491320 countsByYear W28984913202020 @default.
- W2898491320 countsByYear W28984913202022 @default.