FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898492704> ?p ?o ?g. }

• W2898492704 abstract "Abstract Expression of hypoxia-inducible factor (HIF) 1α has been observed in corneal neovascularization (CNV). Vascular endothelial growth factor (VEGF), one of the most well-known angiogenic factors in CNV, is under the regulation of HIF-1. The present study aims to investigate the synergistic effects of VEGF and HIF-1α gene silencing on alkali burn-induced CNV in rabbits. The models of rabbits in corneal alkali burn were established. SiRNA recombinant adenovirus was used to explore the synergistic effects of VEGF and HIF-1α gene silencing on alkali burn-induced CNV. CNV area and ultrastructure of cornea were observed. The expression of VEGF and HIF-1α was detected. CNV was observed in rabbits following alkali burn. In addition, overexpressed VEGF and HIF-1α was also observed in rabbits following alkali burn. Then, silencing HIF-1α or silencing VEGF decreased area of CNV, inhibited neovascularization and improved pathological changes, while double-target interference for VEGF and HIF-1α decreased area of CNV inhibited neovascularization, and improved pathological changes to a greater extent. Our study provides evidences emphasizing the distinct notion that VEGF and HIF-1α play the contributory role in alkali burn-induced CNV as a result of double-target interference for VEGF and HIF-1α inhibiting CNV in rabbits following corneal alkali burn." @default.
• W2898492704 created "2018-11-02" @default.
• W2898492704 creator A5045072517 @default.
• W2898492704 creator A5061146187 @default.
• W2898492704 date "2019-01-01" @default.
• W2898492704 modified "2023-10-14" @default.
• W2898492704 title "Inhibited corneal neovascularization in rabbits following corneal alkali burn by double-target interference for VEGF and HIF-1α" @default.
• W2898492704 cites W1711720708 @default.
• W2898492704 cites W1965369252 @default.
• W2898492704 cites W1967928852 @default.
• W2898492704 cites W2003272769 @default.
• W2898492704 cites W2006920033 @default.
• W2898492704 cites W2016933731 @default.
• W2898492704 cites W2027893779 @default.
• W2898492704 cites W2038451782 @default.
• W2898492704 cites W2043242824 @default.
• W2898492704 cites W2047216329 @default.
• W2898492704 cites W2055503132 @default.
• W2898492704 cites W2068825687 @default.
• W2898492704 cites W2101680696 @default.
• W2898492704 cites W2114812216 @default.
• W2898492704 cites W2121345756 @default.
• W2898492704 cites W2121618767 @default.
• W2898492704 cites W2135664375 @default.
• W2898492704 cites W2153484787 @default.
• W2898492704 cites W2169158011 @default.
• W2898492704 cites W2186407648 @default.
• W2898492704 cites W2288370956 @default.
• W2898492704 cites W2346723991 @default.
• W2898492704 cites W2403958656 @default.
• W2898492704 cites W2409008928 @default.
• W2898492704 cites W2531284457 @default.
• W2898492704 cites W2550276097 @default.
• W2898492704 cites W2566950753 @default.
• W2898492704 cites W2569623852 @default.
• W2898492704 cites W2591366753 @default.
• W2898492704 doi "https://doi.org/10.1042/bsr20180552" @default.
• W2898492704 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6356011" @default.
• W2898492704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30355648" @default.
• W2898492704 hasPublicationYear "2019" @default.
• W2898492704 type Work @default.
• W2898492704 sameAs 2898492704 @default.
• W2898492704 citedByCount "22" @default.
• W2898492704 countsByYear W28984927042020 @default.
• W2898492704 countsByYear W28984927042021 @default.
• W2898492704 countsByYear W28984927042022 @default.
• W2898492704 countsByYear W28984927042023 @default.
• W2898492704 crossrefType "journal-article" @default.
• W2898492704 hasAuthorship W2898492704A5045072517 @default.
• W2898492704 hasAuthorship W2898492704A5061146187 @default.
• W2898492704 hasBestOaLocation W28984927041 @default.
• W2898492704 hasConcept C104317684 @default.
• W2898492704 hasConcept C118487528 @default.
• W2898492704 hasConcept C119056186 @default.
• W2898492704 hasConcept C167734588 @default.
• W2898492704 hasConcept C185592680 @default.
• W2898492704 hasConcept C2776882836 @default.
• W2898492704 hasConcept C2777025900 @default.
• W2898492704 hasConcept C2777844972 @default.
• W2898492704 hasConcept C2778271429 @default.
• W2898492704 hasConcept C2780394083 @default.
• W2898492704 hasConcept C502942594 @default.
• W2898492704 hasConcept C54355233 @default.
• W2898492704 hasConcept C71924100 @default.
• W2898492704 hasConcept C86803240 @default.
• W2898492704 hasConcept C95444343 @default.
• W2898492704 hasConceptScore W2898492704C104317684 @default.
• W2898492704 hasConceptScore W2898492704C118487528 @default.
• W2898492704 hasConceptScore W2898492704C119056186 @default.
• W2898492704 hasConceptScore W2898492704C167734588 @default.
• W2898492704 hasConceptScore W2898492704C185592680 @default.
• W2898492704 hasConceptScore W2898492704C2776882836 @default.
• W2898492704 hasConceptScore W2898492704C2777025900 @default.
• W2898492704 hasConceptScore W2898492704C2777844972 @default.
• W2898492704 hasConceptScore W2898492704C2778271429 @default.
• W2898492704 hasConceptScore W2898492704C2780394083 @default.
• W2898492704 hasConceptScore W2898492704C502942594 @default.
• W2898492704 hasConceptScore W2898492704C54355233 @default.
• W2898492704 hasConceptScore W2898492704C71924100 @default.
• W2898492704 hasConceptScore W2898492704C86803240 @default.
• W2898492704 hasConceptScore W2898492704C95444343 @default.
• W2898492704 hasIssue "1" @default.
• W2898492704 hasLocation W28984927041 @default.
• W2898492704 hasLocation W28984927042 @default.
• W2898492704 hasLocation W28984927043 @default.
• W2898492704 hasLocation W28984927044 @default.
• W2898492704 hasOpenAccess W2898492704 @default.
• W2898492704 hasPrimaryLocation W28984927041 @default.
• W2898492704 hasRelatedWork W115312946 @default.
• W2898492704 hasRelatedWork W1597434638 @default.
• W2898492704 hasRelatedWork W1846134661 @default.
• W2898492704 hasRelatedWork W2073623765 @default.
• W2898492704 hasRelatedWork W2098344681 @default.
• W2898492704 hasRelatedWork W2285542579 @default.
• W2898492704 hasRelatedWork W2354431734 @default.
• W2898492704 hasRelatedWork W2374567618 @default.
• W2898492704 hasRelatedWork W2381070537 @default.
• W2898492704 hasRelatedWork W94450115 @default.
• W2898492704 hasVolume "39" @default.
• W2898492704 isParatext "false" @default.

• next