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- W2898494489 abstract "A practical synthesis of 2,4-methanopyrrolidines was elaborated. The key synthetic step was an intramolecular photochemical [2 + 2]-cycloaddition of an acrylic acid derivative in flow. In spite of a higher molecular weight, 2,4-methanopyrrolidines were shown to have higher solubility in water and lower lipophilicity than pyrrolidines, important characteristics of bioactive molecules in drug design." @default.
- W2898494489 created "2018-11-02" @default.
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- W2898494489 date "2018-10-25" @default.
- W2898494489 modified "2023-10-18" @default.
- W2898494489 title "Photochemical In-Flow Synthesis of 2,4-Methanopyrrolidines: Pyrrolidine Analogues with Improved Water Solubility and Reduced Lipophilicity" @default.
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- W2898494489 doi "https://doi.org/10.1021/acs.joc.8b02071" @default.
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- W2898494489 hasPublicationYear "2018" @default.
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