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• W2898502203 abstract "A recently reported potent inhibitor of enterovirus 71 3C protease, (R)-1, was found to have stability and potential toxicity issues due to the presence of a cyanohydrin moiety. Modifying the labile cyanohydrin moiety, by serendipity, led to the discovery of 4-iminooxazolidin-2-one-based inhibitors 4e and 4g with potent inhibitory activity and significantly improved stability. In vivo pharmacokinetic studies of 4e also demonstrated high plasma exposure and moderate half-life. These compounds have shown potential of becoming anti-EV71 drug candidates." @default.
• W2898502203 created "2018-11-02" @default.
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• W2898502203 date "2018-10-26" @default.
• W2898502203 modified "2023-10-10" @default.
• W2898502203 title "4-Iminooxazolidin-2-one as a Bioisostere of the Cyanohydrin Moiety: Inhibitors of Enterovirus 71 3C Protease" @default.
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• W2898502203 doi "https://doi.org/10.1021/acs.jmedchem.8b01335" @default.
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