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• W2898511316 abstract "Aim: This study was conducted to evaluate the relationship between disease severity, mean platelet volume and platelet distribution width in stable chronic obstructive pulmonary disease. Methods: The study included 120 consecutive patients with stable chronic obstructive pulmonary disease and 30 consecutive age-matched healthy subjects (control group). Patients were classified as A (mild), B (mild to moderate), C (moderate to severe) and D (severe) defined by the GOLD committee and grouped as A/B (n= 60) and C/D (n=60).Results: Platelet levels were not different among the groups. Mean platelet volume was lower in all patients than control group (p=0.001). Level of platelet distribution width was higher in all patients than control group (p=0.018). Mean platelet volume in C/D groups were significantly lower than A/B group (p=0.011) and control group (p=0.001). Mean platelet volume in A/B group were also significantly lower than control group (p=0.001). Erythrocyte sedimentation rates were higher in A/B and C/D groups than control group (p=0.007 and p=0.001, respectively). C-reactive protein levels in control group were significantly lower than C/D group (p=0.001). No statistically significant correlations were observed between mean platelet volume and forced expiratory volume in one second and forced expiratory volume in one second/forced vital capacity or between mean platelet volume and other inflammatory parameters in A/B or C/D groups. Significant positive correlations were found between erythrocyte sedimentation rate and C-reactive protein (r=0.375; p=0.003), and between mean platelet volume and platelet large cell ratio (r=0.749; p=0.001) in C and D groups. Conclusion: It was concluded that mean platelet volume could be used as a negative acute‑phase reactant in evaluation of disease severity of chronic obstructive pulmonary disease as C-reactive protein." @default.
• W2898511316 created "2018-11-02" @default.
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• W2898511316 date "2018-11-30" @default.
• W2898511316 modified "2023-10-16" @default.
• W2898511316 title "Stabil kronik obstrüktif akciğer hastalığında ortalama trombosit hacmi ve trombosit dağılım genişliğinin hastalık şiddeti ile ilişkisinin değerlendirilmesi" @default.
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• W2898511316 doi "https://doi.org/10.25000/acem.444456" @default.
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