Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898518007> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2898518007 endingPage "S566" @default.
- W2898518007 startingPage "S566" @default.
- W2898518007 abstract "Examination of microRNAs expression in plasma could be useful in screening and in early detection of non-small cell lung cancer (NSCLC). One of the most important enzymes in miRNA biogenesis are Dicer and Drosha. Disrupted expression of miRNA with ability to reciprocal regulation of Dicer and Drosha could participate in cancer development. Plasma expression of miR-27-3p, miR-31, miR-182 and miR-195 were analysed in 138 Polish NSCLC patients (median age 65 years, 83 male and 55 female) and in 45 healthy people (median age 62 years, 28 male and 17 female). 57 (41.3%) NSCLC patient were in I-IIIA stage and 81 (58.7%) patients were in IIIB-IV stage. Relative expression of microRNAs between studied groups was compared using U Mann-Whitney test. For assessment of diagnostic accuracy (test sensitivity and specificity), the receiver operating curves (ROC) with area under curve (AUC) analysis were generated. We demonstrated that plasma levels of miR-27-3p, miR-31 and miR-182 were significantly higher (p<0.000001, p=0.00008, p=0.006 respectively) and miR-195 significantly lower (p=0.000002) in NSCLC patients in comparison with healthy donors. Moreover, patients with early stages (I-IIIA) of NSCLC showed significantly higher expression of miR-27a-3p (p<0.000001), miR-31 (p=0.0003) and miR-182 (p=0.000003) than healthy persons. Expression of miR-195 was significantly lower in patients with early stages (I-IIIA) of NSCLC than in healthy donors (p<0.000001). AUC for miR-27a was 0.95 (94% sensitivity and 81% specificity, p<0.00001), for miR-31 was 0.71 (73% sensitivity and 61% specificity, p=0.001), for miR-182 was 0.77 (70% sensitivity and 79% specificity, p<0.00001) and for miR-195 was 0.82 (74% sensitivity and 80% specificity, p=0.00001). Expression of miR-27a, miR-31, miR-182 and miR-195 could distinguish patients with NSCLC from healthy people. The examination of these microRNAs in plasma could be used in non-invasive lung cancer diagnosis. Deregulation of Dicer and Drosha expression by microRNAs could have oncogenic character." @default.
- W2898518007 created "2018-11-02" @default.
- W2898518007 creator A5006849813 @default.
- W2898518007 creator A5023250116 @default.
- W2898518007 creator A5030063666 @default.
- W2898518007 creator A5033466730 @default.
- W2898518007 creator A5047020134 @default.
- W2898518007 creator A5049123166 @default.
- W2898518007 creator A5064369228 @default.
- W2898518007 creator A5070782948 @default.
- W2898518007 creator A5073572288 @default.
- W2898518007 creator A5079664149 @default.
- W2898518007 creator A5079891116 @default.
- W2898518007 creator A5086329390 @default.
- W2898518007 creator A5087508872 @default.
- W2898518007 creator A5090763162 @default.
- W2898518007 creator A5091382769 @default.
- W2898518007 date "2018-10-01" @default.
- W2898518007 modified "2023-10-01" @default.
- W2898518007 title "P1.11-03 MicroRNA with Ability to Reciprocal Regulation of Dicer and Drosha – Plasma Expression Status and Diagnostic Value in Non-Small Cell Lung Cancer" @default.
- W2898518007 doi "https://doi.org/10.1016/j.jtho.2018.08.819" @default.
- W2898518007 hasPublicationYear "2018" @default.
- W2898518007 type Work @default.
- W2898518007 sameAs 2898518007 @default.
- W2898518007 citedByCount "0" @default.
- W2898518007 crossrefType "journal-article" @default.
- W2898518007 hasAuthorship W2898518007A5006849813 @default.
- W2898518007 hasAuthorship W2898518007A5023250116 @default.
- W2898518007 hasAuthorship W2898518007A5030063666 @default.
- W2898518007 hasAuthorship W2898518007A5033466730 @default.
- W2898518007 hasAuthorship W2898518007A5047020134 @default.
- W2898518007 hasAuthorship W2898518007A5049123166 @default.
- W2898518007 hasAuthorship W2898518007A5064369228 @default.
- W2898518007 hasAuthorship W2898518007A5070782948 @default.
- W2898518007 hasAuthorship W2898518007A5073572288 @default.
- W2898518007 hasAuthorship W2898518007A5079664149 @default.
- W2898518007 hasAuthorship W2898518007A5079891116 @default.
- W2898518007 hasAuthorship W2898518007A5086329390 @default.
- W2898518007 hasAuthorship W2898518007A5087508872 @default.
- W2898518007 hasAuthorship W2898518007A5090763162 @default.
- W2898518007 hasAuthorship W2898518007A5091382769 @default.
- W2898518007 hasBestOaLocation W28985180071 @default.
- W2898518007 hasConcept C104317684 @default.
- W2898518007 hasConcept C126322002 @default.
- W2898518007 hasConcept C143998085 @default.
- W2898518007 hasConcept C145059251 @default.
- W2898518007 hasConcept C146357865 @default.
- W2898518007 hasConcept C151730666 @default.
- W2898518007 hasConcept C166703698 @default.
- W2898518007 hasConcept C2776256026 @default.
- W2898518007 hasConcept C2776802755 @default.
- W2898518007 hasConcept C2779867133 @default.
- W2898518007 hasConcept C54355233 @default.
- W2898518007 hasConcept C67705224 @default.
- W2898518007 hasConcept C71924100 @default.
- W2898518007 hasConcept C86803240 @default.
- W2898518007 hasConceptScore W2898518007C104317684 @default.
- W2898518007 hasConceptScore W2898518007C126322002 @default.
- W2898518007 hasConceptScore W2898518007C143998085 @default.
- W2898518007 hasConceptScore W2898518007C145059251 @default.
- W2898518007 hasConceptScore W2898518007C146357865 @default.
- W2898518007 hasConceptScore W2898518007C151730666 @default.
- W2898518007 hasConceptScore W2898518007C166703698 @default.
- W2898518007 hasConceptScore W2898518007C2776256026 @default.
- W2898518007 hasConceptScore W2898518007C2776802755 @default.
- W2898518007 hasConceptScore W2898518007C2779867133 @default.
- W2898518007 hasConceptScore W2898518007C54355233 @default.
- W2898518007 hasConceptScore W2898518007C67705224 @default.
- W2898518007 hasConceptScore W2898518007C71924100 @default.
- W2898518007 hasConceptScore W2898518007C86803240 @default.
- W2898518007 hasIssue "10" @default.
- W2898518007 hasLocation W28985180071 @default.
- W2898518007 hasOpenAccess W2898518007 @default.
- W2898518007 hasPrimaryLocation W28985180071 @default.
- W2898518007 hasRelatedWork W1571427930 @default.
- W2898518007 hasRelatedWork W1991146496 @default.
- W2898518007 hasRelatedWork W2004214805 @default.
- W2898518007 hasRelatedWork W2013779624 @default.
- W2898518007 hasRelatedWork W2064266708 @default.
- W2898518007 hasRelatedWork W2171393946 @default.
- W2898518007 hasRelatedWork W2771661958 @default.
- W2898518007 hasRelatedWork W3163659271 @default.
- W2898518007 hasRelatedWork W4315853590 @default.
- W2898518007 hasRelatedWork W2188380310 @default.
- W2898518007 hasVolume "13" @default.
- W2898518007 isParatext "false" @default.
- W2898518007 isRetracted "false" @default.
- W2898518007 magId "2898518007" @default.
- W2898518007 workType "article" @default.