Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898541141> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2898541141 abstract "Abstract Objective Monitoring the unbound drug concentration in blood in combination therapy is necessary, because its concentration determines the efficacy of drug therapy. This study was designed to explore the effect of Dan Hong Injection (DHI) on the unbound warfarin using two approaches including an in vivo pharmacokinetic and in vitro fluorescence studies. Methods The effect of DHI on the pharmacokinetic properties of the unbound warfarin was investigated by a microdialysis sampling method coupled with LC–MS/MS. The effect of DHI and salvianolic acid B (SaB) on warfarin binding with bovine serum albumin (BSA) was conducted by fluorescence spectrometry. Results The AUC0-tn of warfarin with DHI group was higher than that of warfarin alone group. The result showed that DHI could increase the concentration of unbound warfarin in rat blood, which may be due to the competition between warfarin and DHI as well as its components binding to serum albumin. The competition process was demonstrated by fluorescence study. Conclusion Combination therapy of DHI with warfarin could enhance the release profile of warfarin from serum protein." @default.
- W2898541141 created "2018-11-02" @default.
- W2898541141 creator A5013238240 @default.
- W2898541141 creator A5033739869 @default.
- W2898541141 creator A5045971524 @default.
- W2898541141 creator A5049709192 @default.
- W2898541141 creator A5078765886 @default.
- W2898541141 creator A5088373513 @default.
- W2898541141 date "2019-01-01" @default.
- W2898541141 modified "2023-09-25" @default.
- W2898541141 title "Monitoring unbound warfarin in drug combination therapy by pharmacokinetics and fluorospectrometry" @default.
- W2898541141 cites W1433663893 @default.
- W2898541141 cites W1853358267 @default.
- W2898541141 cites W1971260573 @default.
- W2898541141 cites W1992891849 @default.
- W2898541141 cites W2009611361 @default.
- W2898541141 cites W2013935552 @default.
- W2898541141 cites W2019180935 @default.
- W2898541141 cites W2025322271 @default.
- W2898541141 cites W2029682909 @default.
- W2898541141 cites W2035904900 @default.
- W2898541141 cites W2038857536 @default.
- W2898541141 cites W2047775737 @default.
- W2898541141 cites W2049789253 @default.
- W2898541141 cites W2075227889 @default.
- W2898541141 cites W2076023447 @default.
- W2898541141 cites W2101669068 @default.
- W2898541141 cites W2313692653 @default.
- W2898541141 cites W2313896523 @default.
- W2898541141 cites W2317878391 @default.
- W2898541141 cites W2410651339 @default.
- W2898541141 cites W568398361 @default.
- W2898541141 doi "https://doi.org/10.1016/j.chmed.2018.10.002" @default.
- W2898541141 hasPublicationYear "2019" @default.
- W2898541141 type Work @default.
- W2898541141 sameAs 2898541141 @default.
- W2898541141 citedByCount "0" @default.
- W2898541141 crossrefType "journal-article" @default.
- W2898541141 hasAuthorship W2898541141A5013238240 @default.
- W2898541141 hasAuthorship W2898541141A5033739869 @default.
- W2898541141 hasAuthorship W2898541141A5045971524 @default.
- W2898541141 hasAuthorship W2898541141A5049709192 @default.
- W2898541141 hasAuthorship W2898541141A5078765886 @default.
- W2898541141 hasAuthorship W2898541141A5088373513 @default.
- W2898541141 hasConcept C111113717 @default.
- W2898541141 hasConcept C112705442 @default.
- W2898541141 hasConcept C126322002 @default.
- W2898541141 hasConcept C150903083 @default.
- W2898541141 hasConcept C185592680 @default.
- W2898541141 hasConcept C207001950 @default.
- W2898541141 hasConcept C2776125364 @default.
- W2898541141 hasConcept C2776301958 @default.
- W2898541141 hasConcept C2776999253 @default.
- W2898541141 hasConcept C2779161974 @default.
- W2898541141 hasConcept C2780035454 @default.
- W2898541141 hasConcept C28406088 @default.
- W2898541141 hasConcept C50156730 @default.
- W2898541141 hasConcept C55493867 @default.
- W2898541141 hasConcept C71924100 @default.
- W2898541141 hasConcept C86803240 @default.
- W2898541141 hasConcept C98274493 @default.
- W2898541141 hasConceptScore W2898541141C111113717 @default.
- W2898541141 hasConceptScore W2898541141C112705442 @default.
- W2898541141 hasConceptScore W2898541141C126322002 @default.
- W2898541141 hasConceptScore W2898541141C150903083 @default.
- W2898541141 hasConceptScore W2898541141C185592680 @default.
- W2898541141 hasConceptScore W2898541141C207001950 @default.
- W2898541141 hasConceptScore W2898541141C2776125364 @default.
- W2898541141 hasConceptScore W2898541141C2776301958 @default.
- W2898541141 hasConceptScore W2898541141C2776999253 @default.
- W2898541141 hasConceptScore W2898541141C2779161974 @default.
- W2898541141 hasConceptScore W2898541141C2780035454 @default.
- W2898541141 hasConceptScore W2898541141C28406088 @default.
- W2898541141 hasConceptScore W2898541141C50156730 @default.
- W2898541141 hasConceptScore W2898541141C55493867 @default.
- W2898541141 hasConceptScore W2898541141C71924100 @default.
- W2898541141 hasConceptScore W2898541141C86803240 @default.
- W2898541141 hasConceptScore W2898541141C98274493 @default.
- W2898541141 hasLocation W28985411411 @default.
- W2898541141 hasOpenAccess W2898541141 @default.
- W2898541141 hasPrimaryLocation W28985411411 @default.
- W2898541141 hasRelatedWork W1995735458 @default.
- W2898541141 hasRelatedWork W1998587742 @default.
- W2898541141 hasRelatedWork W2077476753 @default.
- W2898541141 hasRelatedWork W2167792947 @default.
- W2898541141 hasRelatedWork W2252681196 @default.
- W2898541141 hasRelatedWork W2378945660 @default.
- W2898541141 hasRelatedWork W2418050609 @default.
- W2898541141 hasRelatedWork W2898541141 @default.
- W2898541141 hasRelatedWork W3095945419 @default.
- W2898541141 hasRelatedWork W57704608 @default.
- W2898541141 isParatext "false" @default.
- W2898541141 isRetracted "false" @default.
- W2898541141 magId "2898541141" @default.
- W2898541141 workType "article" @default.