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- W2898542441 abstract "Background: Early and effective treatment of inflammatory arthritis (IA) is essential to preserve patients’ functional ability and prevent joint damage. Recent strategies for optimising care have included implementing treatment to target management and utilising ultrasound to guide treatment decisions. The 2010 ACR/EULAR rheumatoid arthritis (RA) classification criteria were also recently developed with the aim of facilitating the study of early IA.Aims: To determine the phenotype, management and outcomes of patients with early IA, defined using the 2010 RA criteria, in clinical practice. Specific objectives were to risk stratify patients according to future disease severity, determine their response to treatment and assess the potential utility of ultrasound within a treatment to target strategy.Methods: An audit and a prospective longitudinal observational study were conducted in patients attending the Leeds Early Arthritis Clinic. Patients were classified as undifferentiated arthritis (UA) or RA according to the 2010 RA criteria at baseline. Logistic regression methods were used to identify baseline predictors of outcome and treatment response.Results: Ultrasound detectable synovitis at baseline was independently associated with a higher rate of methotrexate use, persistence of IA and development of new ultrasound erosions at one year in patients with UA and RA, as well as progression from UA to RA in the subset of patients with UA at baseline. A lack of concordance was observed between clinical and ultrasound determined remission in RA patients receiving treatment-to-target management. In this sub-group, objective baseline measures of disease were predictive of imaging remission in comparison to the predominantly subjective parameters, which were predictive of clinical remission.Conclusions: This verifies the value of ultrasound as a prognostic tool in the risk stratification of patients with early IA, over and above the clinical application of the 2010 RA criteria and clinical assessments. It supports future research in the use of ultrasound within a treatment to target strategy." @default.
- W2898542441 created "2018-11-02" @default.
- W2898542441 creator A5033538873 @default.
- W2898542441 date "2017-09-01" @default.
- W2898542441 modified "2023-09-23" @default.
- W2898542441 title "Optimising Outcomes for Patients with Early Inflammatory Arthritis" @default.
- W2898542441 cites W103703502 @default.
- W2898542441 cites W105025020 @default.
- W2898542441 cites W117574361 @default.
- W2898542441 cites W1271366904 @default.
- W2898542441 cites W128467644 @default.
- W2898542441 cites W1449540316 @default.
- W2898542441 cites W1483140880 @default.
- W2898542441 cites W1485925639 @default.
- W2898542441 cites W149500347 @default.
- W2898542441 cites W1523575018 @default.
- W2898542441 cites W1529784683 @default.
- W2898542441 cites W1549758961 @default.
- W2898542441 cites W1554023045 @default.
- W2898542441 cites W1573288623 @default.
- W2898542441 cites W1580597148 @default.
- W2898542441 cites W1588610010 @default.
- W2898542441 cites W1596295297 @default.
- W2898542441 cites W1596381381 @default.
- W2898542441 cites W1726059930 @default.
- W2898542441 cites W1758551700 @default.
- W2898542441 cites W176108987 @default.
- W2898542441 cites W1761300068 @default.
- W2898542441 cites W1775415256 @default.
- W2898542441 cites W1821977962 @default.
- W2898542441 cites W1824427187 @default.
- W2898542441 cites W1843891486 @default.
- W2898542441 cites W1867887535 @default.
- W2898542441 cites W1898603646 @default.
- W2898542441 cites W1902292563 @default.
- W2898542441 cites W1922571729 @default.
- W2898542441 cites W1922688687 @default.
- W2898542441 cites W1922890095 @default.
- W2898542441 cites W1964809414 @default.
- W2898542441 cites W1964890547 @default.
- W2898542441 cites W1965818605 @default.
- W2898542441 cites W1966425460 @default.
- W2898542441 cites W1966756501 @default.
- W2898542441 cites W1967672301 @default.
- W2898542441 cites W1969236873 @default.
- W2898542441 cites W1969337384 @default.
- W2898542441 cites W1969508240 @default.
- W2898542441 cites W1970522568 @default.
- W2898542441 cites W1972000177 @default.
- W2898542441 cites W1972274662 @default.
- W2898542441 cites W1972291371 @default.
- W2898542441 cites W1972476746 @default.
- W2898542441 cites W1973390579 @default.
- W2898542441 cites W1975357498 @default.
- W2898542441 cites W1975717594 @default.
- W2898542441 cites W1976013201 @default.
- W2898542441 cites W1976144583 @default.
- W2898542441 cites W1979738266 @default.
- W2898542441 cites W1980318567 @default.
- W2898542441 cites W1981229912 @default.
- W2898542441 cites W1981368254 @default.
- W2898542441 cites W1982072041 @default.
- W2898542441 cites W1982125264 @default.
- W2898542441 cites W1982348705 @default.
- W2898542441 cites W1982689297 @default.
- W2898542441 cites W1982974870 @default.
- W2898542441 cites W1983134858 @default.
- W2898542441 cites W1984168638 @default.
- W2898542441 cites W1984825022 @default.
- W2898542441 cites W1985004174 @default.
- W2898542441 cites W1985498235 @default.
- W2898542441 cites W1985658357 @default.
- W2898542441 cites W1987367577 @default.
- W2898542441 cites W1987506287 @default.
- W2898542441 cites W1988660834 @default.
- W2898542441 cites W1991400852 @default.
- W2898542441 cites W1991472750 @default.
- W2898542441 cites W1992205884 @default.
- W2898542441 cites W1994955363 @default.
- W2898542441 cites W1996389186 @default.
- W2898542441 cites W1997392990 @default.
- W2898542441 cites W1997471433 @default.
- W2898542441 cites W1998007422 @default.
- W2898542441 cites W2000333164 @default.
- W2898542441 cites W2000504696 @default.
- W2898542441 cites W2000832741 @default.
- W2898542441 cites W2000853585 @default.
- W2898542441 cites W2001950449 @default.
- W2898542441 cites W2004901535 @default.
- W2898542441 cites W2005429018 @default.
- W2898542441 cites W2006890548 @default.
- W2898542441 cites W2007197867 @default.
- W2898542441 cites W2008302815 @default.
- W2898542441 cites W2011909999 @default.
- W2898542441 cites W2012536047 @default.
- W2898542441 cites W2012620405 @default.
- W2898542441 cites W2014363662 @default.
- W2898542441 cites W2014368601 @default.
- W2898542441 cites W2014657661 @default.
- W2898542441 cites W2014664990 @default.