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• W2898546218 endingPage "1058" @default.
• W2898546218 startingPage "1053" @default.
• W2898546218 abstract "Activation of most primary sensory neurons results in transduction currents that are carried by cations. One notable exception is the vertebrate olfactory receptor neuron (ORN), where the transduction current is carried largely by the anion $Cl^-$. However, it remains unclear why ORNs use an anionic current for signal amplification. We have sought to provide clarification on this topic by studying the so far neglected dynamics of $Na^+$, $Ca^{2+}$, $K^+$ and $Cl^-$ in the small space of olfactory cilia during an odorant response. Using computational modeling and simulations we compared the outcomes of signal amplification based on either $Cl^-$ or $Na^+$ currents. We found that amplification produced by $Na^+$ influx instead of a $Cl^-$ efflux is problematic due to several reasons: First, the $Na^+$ current amplitude varies greatly depending on mucosal ion concentration changes. Second, a $Na^+$ current leads to a large increase in the ciliary $Na^+$ concentration during an odorant response. This increase inhibits and even reverses $Ca^{2+}$ clearance by $Na^+/Ca^{2+}/K^+$ exchange, which is essential for response termination. Finally, a $Na^+$ current increases the ciliary osmotic pressure, which could cause swelling to damage the cilia. By contrast, a transduction pathway based on $Cl^-$ efflux circumvents these problems and renders the odorant response robust and reliable." @default.
• W2898546218 created "2018-11-02" @default.
• W2898546218 creator A5028867664 @default.
• W2898546218 creator A5073271417 @default.
• W2898546218 date "2018-12-31" @default.
• W2898546218 modified "2023-10-03" @default.
• W2898546218 title "Ca ²⁺ -activated Cl ⁻ current ensures robust and reliable signal amplification in vertebrate olfactory receptor neurons" @default.
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• W2898546218 doi "https://doi.org/10.1073/pnas.1816371116" @default.
• W2898546218 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6338846" @default.
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• W2898546218 hasPublicationYear "2018" @default.
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