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- W2898565530 abstract "A highly sensitive LC-MS/MS method was developed to measure oroxin B in rat plasma and tissue homogenates. The analyte and IS were isolated from biological matrices by a simple protein precipitation followed by centrifugation. Detection was conducted by electrospray negative-ionization mass spectrometry in selected-reaction monitoring mode. The assay was linear in the concentration range 4.52-904 ng/mL with intra- and inter-day precision of <14.41%. It was successfully applied to the pharmacokinetics and tissue distribution studies of oroxin B after an intravenous dose of 1.0 mg/kg in rats. The results would be useful for further development of oroxin B." @default.
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- W2898565530 date "2018-11-22" @default.
- W2898565530 modified "2023-10-16" @default.
- W2898565530 title "Pharmacokinetics and tissue distribution of oroxin B in rats using a validated LC–MS/MS assay" @default.
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- W2898565530 doi "https://doi.org/10.1002/bmc.4417" @default.
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