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- W2898568907 endingPage "661" @default.
- W2898568907 startingPage "645" @default.
- W2898568907 abstract "Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide and the second leading cause of death among all cancer types. Deregulation of the networks of tissue-specific transcription factors (TFs) observed in HCC leads to profound changes in the hepatic transcriptional program that facilitates tumor progression. In addition, recent reports suggest that substantial aberrations in the production of TF isoforms occur in HCC. In vitro experiments have identified distinct isoform-specific regulatory functions and related biological effects of liver-specific TFs that are implicated in carcinogenesis, which may be relevant for tumor progression and clinical outcome. This study reviews available data on the expression of isoforms of liver-specific and ubiquitous TFs in the liver and HCC and their effects, including HNF4α, C/EBPs, p73 and TCF7L2, and indicates that assessment of the ratio of isoforms and targeting specific TF variants may be beneficial for the prognosis and treatment of HCC." @default.
- W2898568907 created "2018-11-02" @default.
- W2898568907 creator A5043006511 @default.
- W2898568907 creator A5090365180 @default.
- W2898568907 creator A5091225191 @default.
- W2898568907 date "2018-10-27" @default.
- W2898568907 modified "2023-09-27" @default.
- W2898568907 title "Aberrant expression of alternative isoforms of transcription factors in hepatocellular carcinoma" @default.
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