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- W2898587535 abstract "The substrate specificity of enzymes is bound to be imperfect, because of unavoidable physicochemical limits. In extant metabolic enzymes, furthermore, such limits are seldom approached, suggesting that the degree of specificity of these enzymes, on average, is much lower than could be attained. During biological evolution, the activity of a single enzyme with available alternative substrates may be preserved to a significant or even substantial level for different reasons - for example when the alternative reaction contributes to fitness, or when its undesirable products are nevertheless dispatched by metabolite repair enzymes. In turn, the widespread occurrence of promiscuous reactions is a consistent source of metabolic 'messiness', from which both liabilities and opportunities ensue in the evolution of metabolic systems." @default.
- W2898587535 created "2018-11-02" @default.
- W2898587535 creator A5047289435 @default.
- W2898587535 date "2018-12-01" @default.
- W2898587535 modified "2023-10-10" @default.
- W2898587535 title "The Limits of Enzyme Specificity and the Evolution of Metabolism" @default.
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- W2898587535 doi "https://doi.org/10.1016/j.tibs.2018.09.015" @default.
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