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• W2898605444 startingPage "3539" @default.
• W2898605444 abstract "The use of inhaled corticosteroids (ICS) in combination with bronchodilators in patients with COPD has been shown to decrease the rate of disease exacerbations and to improve the lung function and patients' quality of life. However, their use has also been associated with an increased risk of pneumonia.We have reviewed existing clinical evidence on the risks and benefits of ICS in COPD, including large randomized clinical trials, meta-analyses, and clinical reviews.A large body of evidence supports the clinical benefits of ICS in patients with COPD in terms of exacerbations, symptoms, lung function, and quality of life. The incidence of adverse events related to ICS, including pneumonia, varies strongly among the studies and seems to be dose dependent, with recent well-designed, large studies on low-dose ICS reporting similar safety profiles in ICS and non-ICS groups.The benefits of ICS in COPD continue to outweigh the risks, especially when lower ICS doses are employed. Given that the data on ICS withdrawal in COPD are scarce and conflicting, we argue that using reduced doses of ICS could be an optimal strategy to manage patients with COPD." @default.
• W2898605444 created "2018-11-02" @default.
• W2898605444 creator A5064807814 @default.
• W2898605444 creator A5068320991 @default.
• W2898605444 date "2018-10-01" @default.
• W2898605444 modified "2023-10-16" @default.
• W2898605444 title "The dose of inhaled corticosteroids in patients with COPD: when less is better" @default.
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• W2898605444 doi "https://doi.org/10.2147/copd.s175047" @default.
• W2898605444 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6207269" @default.
• W2898605444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30498343" @default.
• W2898605444 hasPublicationYear "2018" @default.
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