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- W2898671649 abstract "Objectives: To describe the interim effects of the SSaSS study intervention on intermediate outcomes. In particular, whether the 3.0mmHg difference in blood pressure between randomised groups assumed for statistical power is being achieved. Methods: SSaSS is a large-scale cluster randomized controlled trial investigating whether decreasing sodium intake using a reduced-sodium, added-potassium salt substitute can lower the risk of stroke. The integrity of the intervention is tracked by open monitoring of effects on 24-hour sodium excretion, 24-hour potassium excretion and blood pressure in a subset of randomised participants. Results: Data were available for 1198 participants at 12 months, 2789 at 24 months and 1163 at 36 months. Overall, 24-hour sodium excretion was 0.4 g (95%CI: −0.7, −0.1; p = 0.013) lower at follow-up in intervention compared to control groups, whereas 24-hour potassium excretion was 0.7 g (95%CI: 0.6, 0.9; p < 0.001) higher. Systolic blood pressure was 3.1mmHg (95%CI: −4.5, −1.7; p < 0.001) lower but diastolic blood pressure was not different (0.1 mmHg, 95% CI −0.7 to 1.0; p = 0.766). Estimated effects on urinary indicators were comparable across the three years. Point estimates of effects for blood pressure were lesser at year 2 compared to years 1 and 3, though confidence intervals about estimates were wide (Figure 1). Conclusion: These data clearly demonstrate use of the salt substitute by intervention compared to control participants and the overall effect on blood pressure is aligned with initial assumptions underlying statistical power. The apparently discrepant effects on blood pressure in year 2 may reflect the play of chance since effects on urinary sodium and potassium appear constant." @default.
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- W2898671649 date "2018-10-01" @default.
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- W2898671649 title "A13076 Interim effects of salt substitution on urinary electrolytes and blood pressure in the China Salt Substitute and Stroke Study (SSaSS)" @default.
- W2898671649 doi "https://doi.org/10.1097/01.hjh.0000549138.27560.0d" @default.
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