Matches in SemOpenAlex for { <https://semopenalex.org/work/W2898681676> ?p ?o ?g. }
- W2898681676 endingPage "147" @default.
- W2898681676 startingPage "137" @default.
- W2898681676 abstract "Arthritis is a syndrome associated with exacerbated inflammation, joint destruction and chronic pain and disability. Chronic treatment of arthritis is associated with several side effects and high abandonment. Therefore, there has been an ongoing search for alternative treatments to overcome these problems. Natural products, which are already widely used for their biological, cosmetic and pharmacotechnic properties, are a possible source for new drugs. Terpenes, a large class of organic compounds produced mainly by plants and trees, are a promising natural product and have already been shown to be effective in treating chronic pain, particularly of an inflammatory origin. This review identifies the main terpenes with anti-arthritic activity reported in the last 10 years. A survey was conducted between December 2017 and June 2018 in the PUBMED, SCOPUS and Science Direct databases using combinations of the descriptors terpenes, arthritis and inflammation. The results showed that terpenes have promising biological effects in relation to the treatment of arthritis, with the 24 terpenes identified in our survey being effective in the modulation of inflammatory mediators important to the physiopathology of arthritis, such as IL-6, IL-17, TNF-α, NFκB, and COX-2, among others. It is important to note that most of the studies used animal models, which limits, at least in part, the direct translation to humans of the experimental evidence produced by the studies. Together, our finds suggest that terpenes can modulate the immuno-regulatory and destructive tissue events that underlie the clinical presentation and the progression of arthritis and are worthy of further clinical investigation." @default.
- W2898681676 created "2018-11-09" @default.
- W2898681676 creator A5000480790 @default.
- W2898681676 creator A5011194708 @default.
- W2898681676 creator A5017872523 @default.
- W2898681676 creator A5026181865 @default.
- W2898681676 creator A5031080027 @default.
- W2898681676 creator A5037878373 @default.
- W2898681676 creator A5044417808 @default.
- W2898681676 creator A5087599616 @default.
- W2898681676 date "2019-04-01" @default.
- W2898681676 modified "2023-10-16" @default.
- W2898681676 title "Terpenes as possible drugs for the mitigation of arthritic symptoms – A systematic review" @default.
- W2898681676 cites W1521338784 @default.
- W2898681676 cites W1560571961 @default.
- W2898681676 cites W1704129926 @default.
- W2898681676 cites W1873126901 @default.
- W2898681676 cites W1884436975 @default.
- W2898681676 cites W1965404141 @default.
- W2898681676 cites W1966472389 @default.
- W2898681676 cites W1978091951 @default.
- W2898681676 cites W1980379052 @default.
- W2898681676 cites W1980602136 @default.
- W2898681676 cites W1988139178 @default.
- W2898681676 cites W1988468169 @default.
- W2898681676 cites W1990418324 @default.
- W2898681676 cites W1993221712 @default.
- W2898681676 cites W1994606929 @default.
- W2898681676 cites W1994711800 @default.
- W2898681676 cites W1996713852 @default.
- W2898681676 cites W1999586472 @default.
- W2898681676 cites W2000770184 @default.
- W2898681676 cites W2000917302 @default.
- W2898681676 cites W2001641583 @default.
- W2898681676 cites W2003207115 @default.
- W2898681676 cites W2005250923 @default.
- W2898681676 cites W2006930654 @default.
- W2898681676 cites W2009731763 @default.
- W2898681676 cites W2010575607 @default.
- W2898681676 cites W2010934896 @default.
- W2898681676 cites W2014785961 @default.
- W2898681676 cites W2014830732 @default.
- W2898681676 cites W2016310302 @default.
- W2898681676 cites W2019137678 @default.
- W2898681676 cites W2021155950 @default.
- W2898681676 cites W2030133881 @default.
- W2898681676 cites W2031756368 @default.
- W2898681676 cites W2032731042 @default.
- W2898681676 cites W2033138497 @default.
- W2898681676 cites W2036291264 @default.
- W2898681676 cites W2036496476 @default.
- W2898681676 cites W2047886205 @default.
- W2898681676 cites W2049048694 @default.
- W2898681676 cites W2049234525 @default.
- W2898681676 cites W2049314495 @default.
- W2898681676 cites W2054745662 @default.
- W2898681676 cites W2056015006 @default.
- W2898681676 cites W2056154256 @default.
- W2898681676 cites W2056334813 @default.
- W2898681676 cites W2056696895 @default.
- W2898681676 cites W2057830740 @default.
- W2898681676 cites W2058203865 @default.
- W2898681676 cites W2059833442 @default.
- W2898681676 cites W2060410577 @default.
- W2898681676 cites W2060647978 @default.
- W2898681676 cites W2061974695 @default.
- W2898681676 cites W2066515408 @default.
- W2898681676 cites W2068505559 @default.
- W2898681676 cites W2074026595 @default.
- W2898681676 cites W2074089133 @default.
- W2898681676 cites W2074438676 @default.
- W2898681676 cites W2075082022 @default.
- W2898681676 cites W2083370448 @default.
- W2898681676 cites W2083748640 @default.
- W2898681676 cites W2084122602 @default.
- W2898681676 cites W2084125175 @default.
- W2898681676 cites W2087810525 @default.
- W2898681676 cites W2088316894 @default.
- W2898681676 cites W2093277474 @default.
- W2898681676 cites W2101707809 @default.
- W2898681676 cites W2110586471 @default.
- W2898681676 cites W2113074942 @default.
- W2898681676 cites W2121406060 @default.
- W2898681676 cites W2124724850 @default.
- W2898681676 cites W2125882717 @default.
- W2898681676 cites W2127366888 @default.
- W2898681676 cites W2130958310 @default.
- W2898681676 cites W2134974224 @default.
- W2898681676 cites W2135510881 @default.
- W2898681676 cites W2137056765 @default.
- W2898681676 cites W2137323830 @default.
- W2898681676 cites W2137752578 @default.
- W2898681676 cites W2140016144 @default.
- W2898681676 cites W2142328693 @default.
- W2898681676 cites W2142734217 @default.
- W2898681676 cites W2142765548 @default.
- W2898681676 cites W2144730517 @default.
- W2898681676 cites W2148197913 @default.